Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

Información del proyecto

AURORA

Identificador del acuerdo de subvención: 964827

DOI

10.3030/964827

Fecha de la firma de la CE 2 Febrero 2021

Fecha de inicio 1 Abril 2021

Fecha de finalización 30 Septiembre 2026

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 5 996 315,00

Aportación de la UE

€ 5 996 315,00

Coordinado por

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (3)

HRMS profiling of placenta or cord blood metabolome

Report describing the results of the HRMS analyses on biological samples from the BISC and Environage cohort.

Cluster brochure

Leaflet describing the cluster activities and participating projects

Protocols of high-throughput analysis of MNPs

A description of the key requirements to scale analytical methods for population screening including: 1) benchmark quantification methods for MNPs using untargeted Pyr-HRMS against traditional targeted approaches ; 2) identification of best practices for standard selection, eliminating background contamination and reagent purity; 3) evaluation of the effect of sample preparation on MNP chemistry.

Demonstrators, pilots, prototypes (1)

Sample pre-processing workflow and standard operating procedures for measuring MNPs in complex human sample matrices

A report describing workflows and SOPs using the optimized methods – describing the effects of sample treatments on 1) formation of secondary NPs and 2) effects of these treatments on NP, which may react differently than the larger MNPs.

Websites, patent fillings, videos etc. (1)

Database of spectroscopic and morphological fingerprints of aged MNPs

Database on the chemical and morphological changes occurring during NP formation, as well as on the surface of the parent plastic. This will provide a key deliverable supporting MNP risk assessment through developing a database of signatures for in-depth characterization of MNPs.

Publicaciones

Peer reviewed articles (8)

Functional structure of local connections and differentiation of cerebral cortex areas in the neonate

Autores: Jesus Pujol, Laura Blanco-Hinojo, Cecilia Persavento, Gerard Martínez-Vilavella, Carles Falcón, Mireia Gascón, Ioar Rivas, Marc Vilanova, Joan Deus, Juan Domingo Gispert, Maria Dolors Gómez-Roig, Elisa Llurba, Payam Dadvand, Jordi Sunyer
Publicado en: NeuroImage, Edición 298, 2025, Página(s) 120780, ISSN 1053-8119
Editor: Academic Press
DOI: 10.1016/j.neuroimage.2024.120780

Development of a reliable preprocessing protocol for fluorescent micro- and nanoplastic analysis in human placental tissue

Autores: Laura M Zoutendijk, Zenzi Matla, Hanna M Dusza, Barbara M Scholz-Böttcher, Bert M Weckhuysen, Laurens D B Mandemaker, Florian Meirer
Publicado en: Environmental Toxicology and Chemistry, Edición 44, 2025, Página(s) 2818-2831, ISSN 0730-7268
Editor: Society of Environmental Toxicology and Chemistry
DOI: 10.1093/etojnl/vgaf177

Air pollution and fetal brain morphological development: a prospective cohort study

Autores: Laura Gómez-Herrera, Yu Zhao, Ioar Rivas, Elisenda Eixarch, Carla Domínguez-Gallardo, Toni Galmes, Marta Muniesa, Maria Julia Zanini, Alan Domínguez, Marta Cirach, Mark Nieuwenhuijsen, Xavier Basagaña, Xavier Querol, Maria Foraster, Mariona Bustamante, Jesus Pujol, Mireia Gascon, Elisa Llurba, María Dolores Gómez-Roig, Payam Dadvand, Jordi Sunyer
Publicado en: The Lancet Planetary Health, Edición 9, 2025, Página(s) e480-e490, ISSN 2542-5196
Editor: Elsevier BV
DOI: 10.1016/s2542-5196(25)00093-2

Advancements in Assays for Micro- and Nanoplastic Detection: Paving the Way for Biomonitoring and Exposomics Studies

Autores: Kuanliang Shao, Runyu Zou, Zhuoyue Zhang, Laurens D.B. Mandemaker, Sarah Timbie, Ronald D. Smith, Amanda M. Durkin, Hanna M. Dusza, Florian Meirer, Bert M. Weckhuysen, Tanya L. Alderete, Roel Vermuelen, Douglas I. Walker
Publicado en: Annual Review of Pharmacology and Toxicology, Edición 65, 2025, Página(s) 567-585, ISSN 0362-1642
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-pharmtox-030424-112828

Extremely high levels of PBDEs in children’s toys from European markets: causes and implications for the circular economy

Autores: Chijioke Olisah, Lisa Melymuk, Ondrej Audy, Petr Kukucka, Petra Pribylova, Martin Boudot
Publicado en: Environmental Sciences Europe, Edición 36, 2024, ISSN 2190-4715
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s12302-024-00999-2

Investigating Exposure and Hazards of Micro- and Nanoplastics During Pregnancy and Early Life (AURORA Project): Protocol for an Interdisciplinary Study

Autores: Amanda M Durkin, Runyu Zou, Justin M Boucher, Matthew SP Boyles, Jeske van Boxel, Mariona Bustamante, Emily A Christopher, Payam Dadvand, Hanna M Dusza, Majorie van Duursen, Markus M Forsberg, Karen S Galea, Juliette Legler, Laurens DB Mandemaker, Florian Meirer, Jane Muncke, Tim S Nawrot, Petra Přibylová, Anna R Robuck, Nelly D Saenen, Barbara M Scholz-Böttcher, Kuanliang Shao, Martine Vrijhei
Publicado en: JMIR Research Protocols, Edición 13, 2024, Página(s) e63176, ISSN 1929-0748
Editor: JMIR Publications Inc.
DOI: 10.2196/63176

Concentrations of per- and polyfluoroalkyl substances (PFAS) in paired tap water and blood samples during pregnancy

Autores: Dora Cserbik, Maribel Casas, Cintia Flores, Alexandra Paraian, Line Småstuen Haug, Ioar Rivas, Mariona Bustamante, Payam Dadvand, Jordi Sunyer, Martine Vrijheid, Cristina M. Villanueva
Publicado en: Journal of Exposure Science & Environmental Epidemiology, Edición 34, 2024, Página(s) 90-96, ISSN 1559-0631
Editor: Nature Publishing Group
DOI: 10.1038/s41370-023-00581-7

Interlaboratory Comparison Reveals State of the Art in Microplastic Detection and Quantification Methods

Autores: Dmitri Ciornii, Vasile-Dan Hodoroaba, Nizar Benismail, Alina Maltseva, Juan F. Ferrer, Jiamin Wang, Raquel Parra, Ronan Jézéquel, Justine Receveur, Dina Gabriel, Andreas Scheitler, Christa van Oversteeg, Jorg Roosma, Alex van Renesse van Duivenbode, Tim Bulters, Michela Zanella, Alessandro Perini, Federico Benetti, Dora Mehn, Georg Dierkes, Michael Soll, Takahisa Ishimura, Marius Bednarz, Guyu P
Publicado en: Analytical Chemistry, Edición 97, 2025, Página(s) 8719-8728, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.4c05403

Other (8)

Experimental human placental models for studying uptake, transport and toxicity of micro- and nanoplastics

Autores: Hanna M. Dusza a 1, Jeske van Boxel b 1, Majorie B.M. van Duursen b, Markus M. Forsberg c, Juliette Legler a, Kirsi H. Vähäkangas c
Publicado en: Elsevier ScienceDirect, Edición volume 860, 20 february 2023, 2023, Página(s) 160403
Editor: Elsevier, Science direct

Progress Towards an Accurate Detection, Characterization, and Exposure Assessment of Micro and Nanoplastics to Support Risk Assessments for Early Life Health Within the AURORA Project

Autores: Mandemaker, Laurens D. B.; Dusza, Hanna; Meirer, Florian; van Boxel, Jesker; van Duursen, Majorie; Forsberg, Markus; Legler, Juliette; Vähäkangas, Kirsi; Zimmermann, Lisa
Publicado en: online: https://zenodo.org/records/7968133 - online brochure/poster, Edición May 25, 2023 - v1, 2023
Editor: zenodo.org & AURORA/CUSP
DOI: 10.5281/zenodo.7968132

PlasticsFatE Deliverable Report D7.6 Cluster Brochure

Autores: Tobin, Lesley; Kienzl, Sabine; Mata, Virginia; Vivani, Laura; Muncke, Jane; Boucher, Justin
Publicado en: PlasticsFatE Deliverable Report D7.6 Cluster Brochure, Edición 6, 2023
Editor: Zenodo
DOI: 10.5281/zenodo.8092258

PlasticsFatE Deliverable Report D7.7 Joint policy briefs 1

Autores: Foss Hansen, Stephen; Hernandez, Alba
Publicado en: PlasticsFatE Deliverable Report D7.7 Joint policy briefs 1, Edición 6, 2023
Editor: Zenodo
DOI: 10.5281/zenodo.8092278

Spectro‐Microscopic Techniques for Studying Nanoplastics in the Environment and in Organisms

Autores: Laurens D. B. Mandemaker; Florian Meirer
Publicado en: Angewandte Chemie - International Edition, Edición October 24, 2022, 2022
Editor: Wiley-Blackwell
DOI: 10.1002/anie.202210494

PlasticsFatE Deliverable Report D7.5 Cluster web portal and visual identity

Autores: Tobin, Lesley; Muncke, Jane; Vivani, Laura; Kienzl, Sabine; Mata Marcano, Virginia; Steinbach, Christoph; Roordink, Danielle; Boucher, Justin
Publicado en: PlasticsFatE Deliverable Report D7.5 Cluster web portal and visual identity, Edición 6, 2023
Editor: Zenodo
DOI: 10.5281/zenodo.8092193

Impacts of micro- and nanoplastics on early-life health

Autores: Christopher, Emily A.; Christopher-de Vries, Yvette; Devadoss, Anitha; Mandemaker, Laurens D.B.; van Boxel, Jeske; Copsey, Helena M.; Dusza, Hanna M.; Legler, Juliette; Meirer, Florian; Muncke, Jane; Nawrot, Tim S.; Saenen, Nelly D.; Scholz-Böttcher, Barbara M.; Tran, Lang; Weckhuysen, Bert M.; Zou, Runyu; Zimmermann, Lisa; Galea, Karen S.; Vermeulen, Roel; Boyles, Matthew S.P.
Publicado en: Microplastics and Nanoplastics, Edición 2, 2024
Editor: Springer Open
DOI: 10.1186/s43591-024-00089-3

CUSP Brochure

Autores: CUSP
Publicado en: ZENODO, Edición January 12, 2022, 2022
Editor: CUSP: www.cusp-research.eu
DOI: 10.5281/zenodo.5837595

Conference proceedings (1)

Sample Pre-processing Protocols for the (Spectro-)Microscopic Analysis of Micro- & Nanoplastics (MNPs) in Maternal and Fetal Tissues

Autores: Zoutendijk, Laura M.; Mandemaker, Laurens D. B.; Matla, Zenzi; Zimmermann, Lisa; van Dalen, Lonneke; Weckhuysen, Bert M.; Meirer, Florian
Publicado en: Edición 1, 2023
Editor: Zenodo
DOI: 10.5281/zenodo.7967295