Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

Informacje na temat projektu

AURORA

Identyfikator umowy o grant: 964827

DOI

10.3030/964827

Data podpisania przez KE 2 Lutego 2021

Data rozpoczęcia 1 Kwietnia 2021

Data zakończenia 30 Września 2026

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 5 996 315,00

Wkład UE

€ 5 996 315,00

Koordynowany przez

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (3)

HRMS profiling of placenta or cord blood metabolome

Report describing the results of the HRMS analyses on biological samples from the BISC and Environage cohort.

Cluster brochure

Leaflet describing the cluster activities and participating projects

Protocols of high-throughput analysis of MNPs

A description of the key requirements to scale analytical methods for population screening including: 1) benchmark quantification methods for MNPs using untargeted Pyr-HRMS against traditional targeted approaches ; 2) identification of best practices for standard selection, eliminating background contamination and reagent purity; 3) evaluation of the effect of sample preparation on MNP chemistry.

Demonstrators, pilots, prototypes (1)

Sample pre-processing workflow and standard operating procedures for measuring MNPs in complex human sample matrices

A report describing workflows and SOPs using the optimized methods – describing the effects of sample treatments on 1) formation of secondary NPs and 2) effects of these treatments on NP, which may react differently than the larger MNPs.

Websites, patent fillings, videos etc. (1)

Database of spectroscopic and morphological fingerprints of aged MNPs

Database on the chemical and morphological changes occurring during NP formation, as well as on the surface of the parent plastic. This will provide a key deliverable supporting MNP risk assessment through developing a database of signatures for in-depth characterization of MNPs.

Publikacje

Peer reviewed articles (8)

Functional structure of local connections and differentiation of cerebral cortex areas in the neonate

Autorzy: Jesus Pujol, Laura Blanco-Hinojo, Cecilia Persavento, Gerard Martínez-Vilavella, Carles Falcón, Mireia Gascón, Ioar Rivas, Marc Vilanova, Joan Deus, Juan Domingo Gispert, Maria Dolors Gómez-Roig, Elisa Llurba, Payam Dadvand, Jordi Sunyer
Opublikowane w: NeuroImage, Numer 298, 2025, Strona(/y) 120780, ISSN 1053-8119
Wydawca: Academic Press
DOI: 10.1016/j.neuroimage.2024.120780

Development of a reliable preprocessing protocol for fluorescent micro- and nanoplastic analysis in human placental tissue

Autorzy: Laura M Zoutendijk, Zenzi Matla, Hanna M Dusza, Barbara M Scholz-Böttcher, Bert M Weckhuysen, Laurens D B Mandemaker, Florian Meirer
Opublikowane w: Environmental Toxicology and Chemistry, Numer 44, 2025, Strona(/y) 2818-2831, ISSN 0730-7268
Wydawca: Society of Environmental Toxicology and Chemistry
DOI: 10.1093/etojnl/vgaf177

Air pollution and fetal brain morphological development: a prospective cohort study

Autorzy: Laura Gómez-Herrera, Yu Zhao, Ioar Rivas, Elisenda Eixarch, Carla Domínguez-Gallardo, Toni Galmes, Marta Muniesa, Maria Julia Zanini, Alan Domínguez, Marta Cirach, Mark Nieuwenhuijsen, Xavier Basagaña, Xavier Querol, Maria Foraster, Mariona Bustamante, Jesus Pujol, Mireia Gascon, Elisa Llurba, María Dolores Gómez-Roig, Payam Dadvand, Jordi Sunyer
Opublikowane w: The Lancet Planetary Health, Numer 9, 2025, Strona(/y) e480-e490, ISSN 2542-5196
Wydawca: Elsevier BV
DOI: 10.1016/s2542-5196(25)00093-2

Advancements in Assays for Micro- and Nanoplastic Detection: Paving the Way for Biomonitoring and Exposomics Studies

Autorzy: Kuanliang Shao, Runyu Zou, Zhuoyue Zhang, Laurens D.B. Mandemaker, Sarah Timbie, Ronald D. Smith, Amanda M. Durkin, Hanna M. Dusza, Florian Meirer, Bert M. Weckhuysen, Tanya L. Alderete, Roel Vermuelen, Douglas I. Walker
Opublikowane w: Annual Review of Pharmacology and Toxicology, Numer 65, 2025, Strona(/y) 567-585, ISSN 0362-1642
Wydawca: Annual Reviews, Inc.
DOI: 10.1146/annurev-pharmtox-030424-112828

Extremely high levels of PBDEs in children’s toys from European markets: causes and implications for the circular economy

Autorzy: Chijioke Olisah, Lisa Melymuk, Ondrej Audy, Petr Kukucka, Petra Pribylova, Martin Boudot
Opublikowane w: Environmental Sciences Europe, Numer 36, 2024, ISSN 2190-4715
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/s12302-024-00999-2

Investigating Exposure and Hazards of Micro- and Nanoplastics During Pregnancy and Early Life (AURORA Project): Protocol for an Interdisciplinary Study

Autorzy: Amanda M Durkin, Runyu Zou, Justin M Boucher, Matthew SP Boyles, Jeske van Boxel, Mariona Bustamante, Emily A Christopher, Payam Dadvand, Hanna M Dusza, Majorie van Duursen, Markus M Forsberg, Karen S Galea, Juliette Legler, Laurens DB Mandemaker, Florian Meirer, Jane Muncke, Tim S Nawrot, Petra Přibylová, Anna R Robuck, Nelly D Saenen, Barbara M Scholz-Böttcher, Kuanliang Shao, Martine Vrijhei
Opublikowane w: JMIR Research Protocols, Numer 13, 2024, Strona(/y) e63176, ISSN 1929-0748
Wydawca: JMIR Publications Inc.
DOI: 10.2196/63176

Concentrations of per- and polyfluoroalkyl substances (PFAS) in paired tap water and blood samples during pregnancy

Autorzy: Dora Cserbik, Maribel Casas, Cintia Flores, Alexandra Paraian, Line Småstuen Haug, Ioar Rivas, Mariona Bustamante, Payam Dadvand, Jordi Sunyer, Martine Vrijheid, Cristina M. Villanueva
Opublikowane w: Journal of Exposure Science & Environmental Epidemiology, Numer 34, 2024, Strona(/y) 90-96, ISSN 1559-0631
Wydawca: Nature Publishing Group
DOI: 10.1038/s41370-023-00581-7

Interlaboratory Comparison Reveals State of the Art in Microplastic Detection and Quantification Methods

Autorzy: Dmitri Ciornii, Vasile-Dan Hodoroaba, Nizar Benismail, Alina Maltseva, Juan F. Ferrer, Jiamin Wang, Raquel Parra, Ronan Jézéquel, Justine Receveur, Dina Gabriel, Andreas Scheitler, Christa van Oversteeg, Jorg Roosma, Alex van Renesse van Duivenbode, Tim Bulters, Michela Zanella, Alessandro Perini, Federico Benetti, Dora Mehn, Georg Dierkes, Michael Soll, Takahisa Ishimura, Marius Bednarz, Guyu P
Opublikowane w: Analytical Chemistry, Numer 97, 2025, Strona(/y) 8719-8728, ISSN 0003-2700
Wydawca: American Chemical Society
DOI: 10.1021/acs.analchem.4c05403

Other (6)

Experimental human placental models for studying uptake, transport and toxicity of micro- and nanoplastics

Autorzy: Hanna M. Dusza a 1, Jeske van Boxel b 1, Majorie B.M. van Duursen b, Markus M. Forsberg c, Juliette Legler a, Kirsi H. Vähäkangas c
Opublikowane w: Elsevier ScienceDirect, Numer volume 860, 20 february 2023, 2023, Strona(/y) 160403
Wydawca: Elsevier, Science direct

Progress Towards an Accurate Detection, Characterization, and Exposure Assessment of Micro and Nanoplastics to Support Risk Assessments for Early Life Health Within the AURORA Project

Autorzy: Mandemaker, Laurens D. B.; Dusza, Hanna; Meirer, Florian; van Boxel, Jesker; van Duursen, Majorie; Forsberg, Markus; Legler, Juliette; Vähäkangas, Kirsi; Zimmermann, Lisa
Opublikowane w: online: https://zenodo.org/records/7968133 - online brochure/poster, Numer May 25, 2023 - v1, 2023
Wydawca: zenodo.org & AURORA/CUSP
DOI: 10.5281/zenodo.7968132

Spectro‐Microscopic Techniques for Studying Nanoplastics in the Environment and in Organisms

Autorzy: Laurens D. B. Mandemaker; Florian Meirer
Opublikowane w: Angewandte Chemie - International Edition, Numer October 24, 2022, 2022
Wydawca: Wiley-Blackwell
DOI: 10.1002/anie.202210494

PlasticsFatE Deliverable Report D7.5 Cluster web portal and visual identity

Autorzy: Tobin, Lesley; Muncke, Jane; Vivani, Laura; Kienzl, Sabine; Mata Marcano, Virginia; Steinbach, Christoph; Roordink, Danielle; Boucher, Justin
Opublikowane w: PlasticsFatE Deliverable Report D7.5 Cluster web portal and visual identity, Numer 6, 2023
Wydawca: Zenodo
DOI: 10.5281/zenodo.8092193

Impacts of micro- and nanoplastics on early-life health

Autorzy: Christopher, Emily A.; Christopher-de Vries, Yvette; Devadoss, Anitha; Mandemaker, Laurens D.B.; van Boxel, Jeske; Copsey, Helena M.; Dusza, Hanna M.; Legler, Juliette; Meirer, Florian; Muncke, Jane; Nawrot, Tim S.; Saenen, Nelly D.; Scholz-Böttcher, Barbara M.; Tran, Lang; Weckhuysen, Bert M.; Zou, Runyu; Zimmermann, Lisa; Galea, Karen S.; Vermeulen, Roel; Boyles, Matthew S.P.
Opublikowane w: Microplastics and Nanoplastics, Numer 2, 2024
Wydawca: Springer Open
DOI: 10.1186/s43591-024-00089-3

CUSP Brochure

Autorzy: CUSP
Opublikowane w: ZENODO, Numer January 12, 2022, 2022
Wydawca: CUSP: www.cusp-research.eu
DOI: 10.5281/zenodo.5837595

Conference proceedings (1)

Sample Pre-processing Protocols for the (Spectro-)Microscopic Analysis of Micro- & Nanoplastics (MNPs) in Maternal and Fetal Tissues

Autorzy: Zoutendijk, Laura M.; Mandemaker, Laurens D. B.; Matla, Zenzi; Zimmermann, Lisa; van Dalen, Lonneke; Weckhuysen, Bert M.; Meirer, Florian
Opublikowane w: Numer 1, 2023
Wydawca: Zenodo
DOI: 10.5281/zenodo.7967295