Deliverables Documents, reports (4) Stakeholder-driven priorities document published by SAG We will take advantage of our first kickoff meeting to elaborate the report to highlight SAG roles in developing longterm project applications and bring their own sectors and organisations priorities in line with the overall PrecisionTox goal and Project objectives Protocols for routine and higher-throughput processing of experimental samples for multi-omics analysis Written Standard Operating Protocols will be written that are version controlled and that provide a stepbystep set of instructions on how to conduct automated and highthroughput extractions for RNA and metabolite analysis for each of the NSOs and human cell lines A detailed description on how to incorporate a beadbased tissue and cell homogeniser and stateoftheart liquid handling robotics will be included First loaded database and associated schema First version of the central database for the PrecisionTox project will be created for the purposes of managing all of the data produced by or used by the consortium This database will allow fast and relevant queries by defining links between chemicals genesproteins phenotypes and all of the associated information that can be obtained from existing external sources In addition to simple textbased queries it will offer sequence eg BLAST and chemoinformatics eg Open Babel RDKit CDK searches Project website We will first explore alternatives for web frameworks, consult graphic designers and launch the website with content by M3. The website will include a presentation of the project objectives and partners, a repository for open access peer reviewed publication (subject to dissemination permissions from the Project), newsletters, links to partners websites, regular updates regarding the project developments and activities (events, webinars), and will embed videos, podcasts, articles and press releases. Open Research Data Pilot (1) Data Management Plan Written Data Management Plan DMP that incorporates the outputs of the WPs following H2020 project guidelines defining a strategy that ensures findability accessibility interoperability and reusability of all digital asset ensuring FAIRness in all phases of the data life cycle ie data generation curation storage processing handling metadata and dissemination of and access to the project data The report will document the data format specifications terminologies and data repositories vetted by the community and relevant to the project A first initial plan will be formulated at month 12 and the final version of the PrecisionTox Data Management Plan will be made available at month 36 Publications Peer reviewed articles (12) Zebrafish regulatory genomic resources for disease modelling and regeneration Author(s): Ada Jimenez Gonzalez; Damir Baranasic; Ferenc Müller Published in: Disease Models & Mechanisms, Issue Volume 16, Issue 8, 2023, ISSN 1754-8411 Publisher: Company of Biologists DOI: 10.1242/dmm.050280 Reactivity of Acrylamides Causes Cytotoxicity and Activates Oxidative Stress Response Author(s): Julia Huchthausen, Beate I. Escher*, Nico Grasse, Maria König, Stephan Beil, and Luise Henneberger Published in: Chemical Research in Toxicology, Issue Volume 36, 2023, Page(s) 1374-1385, ISSN 0893-228X Publisher: American Chemical Society DOI: 10.1021/acs.chemrestox.3c00115 Assessment of Chemical Toxicity in Adult <em>Drosophila Melanogaster</em> Author(s): Jessica M. Holsopple; Shannon R. Smoot; Ellen M. Popodi; John K. Colbourne; Joseph R. Shaw; Brian Oliver; Thomas C. Kaufman; Jason M. Tennessen Published in: JoVE, Issue 193, 2023, ISSN 1940-087X Publisher: MYJoVE Corporation DOI: 10.3791/65029 ELIXIR and Toxicology: a community in development Author(s): Marvin Martens; Rob Stierum; Emma L. Schymanski; Chris T. Evelo; Reza Aalizadeh; Hristo Aladjov; Kasia Arturi; Karine Audouze; Pavel Babica; Karel Berka; Jos Bessems; Ludek Blaha; Evan E Bolton; Montserrat Cases; Dimitrios Damalas; Kirtan Dave; Marco Dilger; Thomas Exner; Daan P. Geerke; Roland C. Grafström; Alasdair J. G. Gray; John M. Hancock; Henner Hollert; Nina Jeliazkova; Danyel Jennen; Fab Published in: F1000Research, Issue 1, 2021, ISSN 2046-1402 Publisher: F1000 Research Ltd. DOI: 10.12688/f1000research.74502.1 Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements Author(s): Damir Baranasic; Matthias Hörtenhuber; Piotr J. Balwierz; Tobias Zehnder; Abdul Kadir Mukarram; Chirag Nepal; Csilla Várnai; Yavor Hadzhiev; Ada Jimenez-Gonzalez; Nan Li; Joseph Wragg; Fabio M. D’Orazio; Dorde Relic; Mikhail Pachkov; Noelia Díaz; Benjamín Hernández-Rodríguez; Zelin Chen; Marcus Stoiber; Michaël Dong; Irene Stevens; Samuel E. Ross; Anne Eagle; Ryan Martin; Oluwapelumi Obas Published in: Nature Genetics, Issue Volume 54, 2022, Page(s) 1037-1050, ISSN 1061-4036 Publisher: Nature Publishing Group DOI: 10.1038/s41588-022-01089-w Toxicity by descent: A comparative approach for chemical hazard assessment Author(s): John K. Colbourne, Joseph R. Shaw, Elena Sostare, Claudia Rivetti, Romain Derelle, Rosemary Barnett, Bruno Campos, Carlie LaLone, Mark R. Viant, Geoff Hodges, Published in: Environmental Advances, Issue Volume 9, 2022, ISSN 2666-7657 Publisher: Elsevier BV DOI: 10.1016/j.envadv.2022.100287 Modernizing persistence–bioaccumulation–toxicity (PBT) assessment with high throughput animal-free methods Author(s): Escher, Beate I; Altenburger, Rolf; Blüher, Matthias; Colbourne, John K; Ebinghaus, Ralf; Fantke, Peter; Hein, Michaela; Köck, Wolfgang; Kümmerer, Klaus; Leipold, Sina; Li, Xiaojing; Scheringer, Martin; Scholz, Stefan; Schloter, Michael; Schweizer, Pia-Johanna; Tal, Tamara; Tetko, Igor; Traidl-Hoffmann, Claudia; Wick, Lukas Y; Fenner, Kathrin Published in: Archives of Toxicology, Issue Volume 97, 2023, Page(s) 1267-1283, ISSN 0340-5761 Publisher: Springer Verlag DOI: 10.1007/s00204-023-03485-5 Precision toxicology: new approach methodologies for chemical safety Author(s): Aleksandra Cavoski, John Colbourne, Laura Holden, Robert Lee Published in: Bio-Science Law Review, Issue Volume 19, Issue 3, 2024, Page(s) 101-107, ISSN 1365-8867 Publisher: Lawtext Publishing Ltd The Precision Toxicology initiative Author(s): The PrecisionTox Consortium Published in: Toxicology Letters, Issue Volume 383, 2023, Page(s) 33-42, ISSN 0378-4274 Publisher: Elsevier BV DOI: 10.1016/j.toxlet.2023.05.004 Knowledge-Driven Approaches to Create the MTox700+ Metabolite Panel for Predicting Toxicity Author(s): Elena Sostare, Thomas N Lawson, Lucy R Saunders, John K Colbourne, Ralf J M Weber, Tomasz Sobanski, Mark R Viant Published in: Toxicological Sciences, Issue Volume 186, Issue 2, 2022, Page(s) 208-220, ISSN 1096-6080 Publisher: Oxford University Press DOI: 10.1093/toxsci/kfac007 The hologenome of <i>Daphnia magna</i> reveals possible DNA methylation and microbiome-mediated evolution of the host genome Author(s): Anurag Chaturvedi; Xiaojing Li; Vignesh Dhandapani; Hollie Marshall; Stephen Kissane; Maria Cuenca-Cambronero; Giovanni Asole; Ferriol Calvet; Marina Ruiz-Romero; Paolo Marangio; Roderic Guigó; Daria Rago; Leda Mirbahai; Niamh Eastwood; John K Colbourne; Jiarui Zhou; Eamonn Mallon; Luisa Orsini Published in: Nucleic Acids Research, Issue Volume 51, Issue 18, 2023, Page(s) 9785-9803, ISSN 1096-6080 Publisher: Oxford University Press DOI: 10.1093/nar/gkad685 Reviewing science-based decisions: CWS Powder Coatings GmbH v European Commission Author(s): Aleksandra Cavoski, Laura Holden, Robert Lee Published in: Environmental Liability - Law, Policy and Practice, Issue Volume 28, Issue 1, 2023, Page(s) 16-22, ISSN 0966-2030 Publisher: Lawtext Publishing Ltd Searching for OpenAIRE data... 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