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CORDIS - Resultados de investigaciones de la UE
CORDIS

Toward Precision Toxicology: New Approach Methodologies for Chemical Safety

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Stakeholder-driven priorities document published by SAG (se abrirá en una nueva ventana)

We will take advantage of our first kickoff meeting to elaborate the report to highlight SAG roles in developing longterm project applications and bring their own sectors and organisations priorities in line with the overall PrecisionTox goal and Project objectives

Shortlist of exploitation options for industry usage of NAM biomarkers (se abrirá en una nueva ventana)

This deliverable maps those areas of EU law in which forms of chemical risk assessment are mandated or encouraged. Producing this overview of the relevant regulatory settings enables an analysis of the functionality of NAM biomarkers and their capacity to deliver on regulatory imperatives. We would envision a web based tool that would assist both researchers and regulatory agencies to locate appropriate settings for NAM biomarkers.

Protocols for routine and higher-throughput processing of experimental samples for multi-omics analysis (se abrirá en una nueva ventana)

Written Standard Operating Protocols will be written that are version controlled and that provide a stepbystep set of instructions on how to conduct automated and highthroughput extractions for RNA and metabolite analysis for each of the NSOs and human cell lines A detailed description on how to incorporate a beadbased tissue and cell homogeniser and stateoftheart liquid handling robotics will be included

First loaded database and associated schema (se abrirá en una nueva ventana)

First version of the central database for the PrecisionTox project will be created for the purposes of managing all of the data produced by or used by the consortium This database will allow fast and relevant queries by defining links between chemicals genesproteins phenotypes and all of the associated information that can be obtained from existing external sources In addition to simple textbased queries it will offer sequence eg BLAST and chemoinformatics eg Open Babel RDKit CDK searches

Report on socio-technical barriers to the take up of NAMs (se abrirá en una nueva ventana)

This report addresses factors which may inhibit the take-up on NAMs. Such factors are not merely technical but involve a range of social, economic and political factors that may create path dependency on existing methods and even resistance to transition. The socio-technical analysis explores how co-production of NAMs through multidimensional engagement around industrial imperatives, market behaviours, chemicals policy, civil society perspectives and technological innovation may help embed NAMs into the fabric of chemical risk assessment.

Project website (se abrirá en una nueva ventana)

We will first explore alternatives for web frameworks, consult graphic designers and launch the website with content by M3. The website will include a presentation of the project objectives and partners, a repository for open access peer reviewed publication (subject to dissemination permissions from the Project), newsletters, links to partners websites, regular updates regarding the project developments and activities (events, webinars), and will embed videos, podcasts, articles and press releases.

Data Management Plan (se abrirá en una nueva ventana)

Written Data Management Plan DMP that incorporates the outputs of the WPs following H2020 project guidelines defining a strategy that ensures findability accessibility interoperability and reusability of all digital asset ensuring FAIRness in all phases of the data life cycle ie data generation curation storage processing handling metadata and dissemination of and access to the project data The report will document the data format specifications terminologies and data repositories vetted by the community and relevant to the project A first initial plan will be formulated at month 12 and the final version of the PrecisionTox Data Management Plan will be made available at month 36

Data submission to Data Commons (WP5) with response profiles for 50 chemicals (se abrirá en una nueva ventana)

All phenotypic measurement data (except for the omics data that is generated and described in WP3) – for the first 50 test chemicals – will be reported to the Data Commons. This will include cytotoxicity data, measurements of embryo toxicity and teratology, measurements of endocrine disruption endpoints, cardiotoxicity and photomotor and other motor behaviours.

Publicaciones

A web-based histology atlas for the freshwater crustacean<i>Daphnia magna</i> (se abrirá en una nueva ventana)

Autores: Mee S. Ngu; Daniel J. Vanselow; Carolyn R. Zaino; Debra A. Shearer; Chadwick Harris; Maksim A. Yakovlev; Spencer R. Katz; Alex Y. Lin; Jean E. Copper; Dula Parkinson; Margaret J. Beaton; John K. Colbourne; Keith C. Cheng; Khai C. Ang
Publicado en: 2022
Editor: bioRxiv
DOI: 10.1101/2022.03.09.483544

The herbicide acetochlor causes lipid peroxidation by inhibition of glutathione peroxidase 4 (se abrirá en una nueva ventana)

Autores: Fahmi Mesmar, Maram Muhsen, Jason P. Tourigny, Jason M. Tennessen, Maria Bondesson
Publicado en: 2023
Editor: bioRxiv
DOI: 10.1101/2023.04.14.536563

Zebrafish regulatory genomic resources for disease modelling and regeneration (se abrirá en una nueva ventana)

Autores: Ada Jimenez Gonzalez; Damir Baranasic; Ferenc Müller
Publicado en: Disease Models & Mechanisms, Edición Volume 16, Edición 8, 2023, ISSN 1754-8411
Editor: Company of Biologists
DOI: 10.1242/dmm.050280

Reactivity of Acrylamides Causes Cytotoxicity and Activates Oxidative Stress Response (se abrirá en una nueva ventana)

Autores: Julia Huchthausen, Beate I. Escher*, Nico Grasse, Maria König, Stephan Beil, and Luise Henneberger
Publicado en: Chemical Research in Toxicology, Edición Volume 36, 2023, Página(s) 1374-1385, ISSN 0893-228X
Editor: American Chemical Society
DOI: 10.1021/acs.chemrestox.3c00115

"Preprint: ""Be Sustainable Recommendations"" for FAIR Resources in Life Sciences research: EOSC-Life's Lessons" (se abrirá en una nueva ventana)

Autores: David, Romain; Rybina, Arina; Burel, Jean-Marie; Heriche, Jean-Karim; Audergon, Pauline; Boiten, Jan-Willem; Coppens, Frederik; Crockett, Sara; Exter Katrina; Fahrener, Sven; Fratelli, Maddalena; Goble, Carole; Gormanns, Philipp; Grantner, Tobias; Gruning, Bjorn; Gurwitz, Kim Tamara; Hancock, John; Harmse, Henriette; Holub, Petr; Juty, Nick; Karnbach, Geoffrey; Karoune, Emma; Keppler, Antje; Kleme
Publicado en: EMBO journal, 2023, ISSN 1460-2075
Editor: European Molecular Biology Organization
DOI: 10.15252/embj.2023115008

Assessment of Chemical Toxicity in Adult &lt;em&gt;Drosophila Melanogaster&lt;/em&gt; (se abrirá en una nueva ventana)

Autores: Jessica M. Holsopple; Shannon R. Smoot; Ellen M. Popodi; John K. Colbourne; Joseph R. Shaw; Brian Oliver; Thomas C. Kaufman; Jason M. Tennessen
Publicado en: JoVE, Edición 193, 2023, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/65029

ELIXIR and Toxicology: a community in development (se abrirá en una nueva ventana)

Autores: Marvin Martens; Rob Stierum; Emma L. Schymanski; Chris T. Evelo; Reza Aalizadeh; Hristo Aladjov; Kasia Arturi; Karine Audouze; Pavel Babica; Karel Berka; Jos Bessems; Ludek Blaha; Evan E Bolton; Montserrat Cases; Dimitrios Damalas; Kirtan Dave; Marco Dilger; Thomas Exner; Daan P. Geerke; Roland C. Grafström; Alasdair J. G. Gray; John M. Hancock; Henner Hollert; Nina Jeliazkova; Danyel Jennen; Fab
Publicado en: F1000Research, 2021, ISSN 2046-1402
Editor: F1000 Research Ltd.
DOI: 10.12688/f1000research.74502.2

Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements (se abrirá en una nueva ventana)

Autores: Damir Baranasic; Matthias Hörtenhuber; Piotr J. Balwierz; Tobias Zehnder; Abdul Kadir Mukarram; Chirag Nepal; Csilla Várnai; Yavor Hadzhiev; Ada Jimenez-Gonzalez; Nan Li; Joseph Wragg; Fabio M. D’Orazio; Dorde Relic; Mikhail Pachkov; Noelia Díaz; Benjamín Hernández-Rodríguez; Zelin Chen; Marcus Stoiber; Michaël Dong; Irene Stevens; Samuel E. Ross; Anne Eagle; Ryan Martin; Oluwapelumi Obas
Publicado en: Nature Genetics, Edición Volume 54, 2022, Página(s) 1037-1050, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-022-01089-w

Evaluating Toxicity of Chemicals using a Zebrafish Vibration Startle Response Screening System (se abrirá en una nueva ventana)

Autores: Hayot, G., Marcato, D., Cramer von Clausbruch, C. A., Pace, G., Strähle, U., Colbourne, J. K., Pylatiuk, C., Peravali, R., Weiss, C., Scholz, S., Dickmeis, T.
Publicado en: JoVE, 2024, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/66153

Toxicity by descent: A comparative approach for chemical hazard assessment (se abrirá en una nueva ventana)

Autores: John K. Colbourne, Joseph R. Shaw, Elena Sostare, Claudia Rivetti, Romain Derelle, Rosemary Barnett, Bruno Campos, Carlie LaLone, Mark R. Viant, Geoff Hodges,
Publicado en: Environmental Advances, Edición Volume 9, 2022, ISSN 2666-7657
Editor: Elsevier BV
DOI: 10.1016/j.envadv.2022.100287

Community-driven governance of FAIRness assessment: an open issue, an open discussion (se abrirá en una nueva ventana)

Autores: Wilkinson, Mark D.; Sansone, Susanna-Assunta; Méndez, Eva; David, Romain; Dennis, Richard; Hecker, David; Kleemola, Mari; Lacagnina, Carlo; Nikiforova, Anastasija; Castro, Leyla Jael
Publicado en: Open Research Europe, 2023, ISSN 2732-5121
Editor: F1000 Research Limited on behalf of the European Commission
DOI: 10.12688/openreseurope.15364.1

Modernizing persistence–bioaccumulation–toxicity (PBT) assessment with high throughput animal-free methods (se abrirá en una nueva ventana)

Autores: Escher, Beate I; Altenburger, Rolf; Blüher, Matthias; Colbourne, John K; Ebinghaus, Ralf; Fantke, Peter; Hein, Michaela; Köck, Wolfgang; Kümmerer, Klaus; Leipold, Sina; Li, Xiaojing; Scheringer, Martin; Scholz, Stefan; Schloter, Michael; Schweizer, Pia-Johanna; Tal, Tamara; Tetko, Igor; Traidl-Hoffmann, Claudia; Wick, Lukas Y; Fenner, Kathrin
Publicado en: Archives of Toxicology, Edición Volume 97, 2023, Página(s) 1267-1283, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-023-03485-5

Precision toxicology: new approach methodologies for chemical safety

Autores: Aleksandra Cavoski, John Colbourne, Laura Holden, Robert Lee
Publicado en: Bio-Science Law Review, Edición Volume 19, Edición 3, 2024, Página(s) 101-107, ISSN 1365-8867
Editor: Lawtext Publishing Ltd

Daphnia as a Sentinel Species for Environmental Health Protection: A Perspective on Biomonitoring and Bioremediation of Chemical Pollution (se abrirá en una nueva ventana)

Autores: Muhammad Abdullahi, Xiaojing Li*, Mohamed Abou-Elwafa Abdallah, William Stubbings, Norman Yan, Marianne Barnard, Liang-Hong Guo, John K. Colbourne, and Luisa Orsini
Publicado en: Environmental Science & Technology, 2022, ISSN 0013-936X
Editor: American Chemical Society
DOI: 10.1021/acs.est.2c01799

The FAIR Cookbook - the essential resource for and by FAIR doers (se abrirá en una nueva ventana)

Autores: Philippe Rocca-Serra; Wei Gu; Vassilios Ioannidis; Tooba Abbassi Daloii; Salvador Capella-Gutierrez; Ishwar Chandramouliswaran; Andrea Splendiani; Tony Burdett; Robert T. Giessmann; David Henderson; Dominique Batista; Allyson Lister; Ibrahim Emam; Yojana Gadiya; Lucas Giovanni; Egon Willighagen; Chris Evelo; Alasdair J. G. Gray; Philip Gribbon; Nick Juty; Danielle Welter; Karsten Quast; Paul Peete
Publicado en: Scientific Data, 2023, ISSN 2052-4463
Editor: Springer Nature
DOI: 10.1038/s41597-023-02166-3

Perspectives on the Drosophila melanogaster Model for Advances in Toxicological Science (se abrirá en una nueva ventana)

Autores: Matthew D. Rand, Jason M. Tennessen, Trudy F. C. Mackay, Robert R. H. Anholt
Publicado en: Current Protocols, 2023, ISSN 2691-1299
Editor: Wiley
DOI: 10.1002/cpz1.870

The Precision Toxicology initiative (se abrirá en una nueva ventana)

Autores: The PrecisionTox Consortium
Publicado en: Toxicology Letters, Edición Volume 383, 2023, Página(s) 33-42, ISSN 0378-4274
Editor: Elsevier BV
DOI: 10.1016/j.toxlet.2023.05.004

The hologenome of <i>Daphnia magna</i> reveals possible DNA methylation and microbiome-mediated evolution of the host genome (se abrirá en una nueva ventana)

Autores: Anurag Chaturvedi; Xiaojing Li; Vignesh Dhandapani; Hollie Marshall; Stephen Kissane; Maria Cuenca-Cambronero; Giovanni Asole; Ferriol Calvet; Marina Ruiz-Romero; Paolo Marangio; Roderic Guigó; Daria Rago; Leda Mirbahai; Niamh Eastwood; John K Colbourne; Jiarui Zhou; Eamonn Mallon; Luisa Orsini
Publicado en: Nucleic Acids Research, Edición Volume 51, Edición 18, 2023, Página(s) 9785-9803, ISSN 1096-6080
Editor: Oxford University Press
DOI: 10.1093/nar/gkad685

FAIR by design: study design-driven creation of standards compliant metadata (se abrirá en una nueva ventana)

Autores: Batista, Dominique; Jones, Martin; Weber, Ralf; Rocca-Serra, Philippe; Sansone, Susanna-Assunta
Publicado en: 2023
Editor: Zenodo
DOI: 10.5281/zenodo.7847620

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