CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.
Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .
Rezultaty
We will take advantage of our first kickoff meeting to elaborate the report to highlight SAG roles in developing longterm project applications and bring their own sectors and organisations priorities in line with the overall PrecisionTox goal and Project objectives
Shortlist of exploitation options for industry usage of NAM biomarkers (odnośnik otworzy się w nowym oknie)This deliverable maps those areas of EU law in which forms of chemical risk assessment are mandated or encouraged. Producing this overview of the relevant regulatory settings enables an analysis of the functionality of NAM biomarkers and their capacity to deliver on regulatory imperatives. We would envision a web based tool that would assist both researchers and regulatory agencies to locate appropriate settings for NAM biomarkers.
Protocols for routine and higher-throughput processing of experimental samples for multi-omics analysis (odnośnik otworzy się w nowym oknie)Written Standard Operating Protocols will be written that are version controlled and that provide a stepbystep set of instructions on how to conduct automated and highthroughput extractions for RNA and metabolite analysis for each of the NSOs and human cell lines A detailed description on how to incorporate a beadbased tissue and cell homogeniser and stateoftheart liquid handling robotics will be included
First loaded database and associated schema (odnośnik otworzy się w nowym oknie)First version of the central database for the PrecisionTox project will be created for the purposes of managing all of the data produced by or used by the consortium This database will allow fast and relevant queries by defining links between chemicals genesproteins phenotypes and all of the associated information that can be obtained from existing external sources In addition to simple textbased queries it will offer sequence eg BLAST and chemoinformatics eg Open Babel RDKit CDK searches
Report on socio-technical barriers to the take up of NAMs (odnośnik otworzy się w nowym oknie)This report addresses factors which may inhibit the take-up on NAMs. Such factors are not merely technical but involve a range of social, economic and political factors that may create path dependency on existing methods and even resistance to transition. The socio-technical analysis explores how co-production of NAMs through multidimensional engagement around industrial imperatives, market behaviours, chemicals policy, civil society perspectives and technological innovation may help embed NAMs into the fabric of chemical risk assessment.
Project website (odnośnik otworzy się w nowym oknie)We will first explore alternatives for web frameworks, consult graphic designers and launch the website with content by M3. The website will include a presentation of the project objectives and partners, a repository for open access peer reviewed publication (subject to dissemination permissions from the Project), newsletters, links to partners websites, regular updates regarding the project developments and activities (events, webinars), and will embed videos, podcasts, articles and press releases.
Written Data Management Plan DMP that incorporates the outputs of the WPs following H2020 project guidelines defining a strategy that ensures findability accessibility interoperability and reusability of all digital asset ensuring FAIRness in all phases of the data life cycle ie data generation curation storage processing handling metadata and dissemination of and access to the project data The report will document the data format specifications terminologies and data repositories vetted by the community and relevant to the project A first initial plan will be formulated at month 12 and the final version of the PrecisionTox Data Management Plan will be made available at month 36
All phenotypic measurement data (except for the omics data that is generated and described in WP3) – for the first 50 test chemicals – will be reported to the Data Commons. This will include cytotoxicity data, measurements of embryo toxicity and teratology, measurements of endocrine disruption endpoints, cardiotoxicity and photomotor and other motor behaviours.
Publikacje
Autorzy:
Mee S. Ngu; Daniel J. Vanselow; Carolyn R. Zaino; Debra A. Shearer; Chadwick Harris; Maksim A. Yakovlev; Spencer R. Katz; Alex Y. Lin; Jean E. Copper; Dula Parkinson; Margaret J. Beaton; John K. Colbourne; Keith C. Cheng; Khai C. Ang
Opublikowane w:
2022
Wydawca:
bioRxiv
DOI:
10.1101/2022.03.09.483544
Autorzy:
Fahmi Mesmar, Maram Muhsen, Jason P. Tourigny, Jason M. Tennessen, Maria Bondesson
Opublikowane w:
2023
Wydawca:
bioRxiv
DOI:
10.1101/2023.04.14.536563
Autorzy:
Ada Jimenez Gonzalez; Damir Baranasic; Ferenc Müller
Opublikowane w:
Disease Models & Mechanisms, Numer Volume 16, Numer 8, 2023, ISSN 1754-8411
Wydawca:
Company of Biologists
DOI:
10.1242/dmm.050280
Autorzy:
Julia Huchthausen, Beate I. Escher*, Nico Grasse, Maria König, Stephan Beil, and Luise Henneberger
Opublikowane w:
Chemical Research in Toxicology, Numer Volume 36, 2023, Strona(/y) 1374-1385, ISSN 0893-228X
Wydawca:
American Chemical Society
DOI:
10.1021/acs.chemrestox.3c00115
Autorzy:
David, Romain; Rybina, Arina; Burel, Jean-Marie; Heriche, Jean-Karim; Audergon, Pauline; Boiten, Jan-Willem; Coppens, Frederik; Crockett, Sara; Exter Katrina; Fahrener, Sven; Fratelli, Maddalena; Goble, Carole; Gormanns, Philipp; Grantner, Tobias; Gruning, Bjorn; Gurwitz, Kim Tamara; Hancock, John; Harmse, Henriette; Holub, Petr; Juty, Nick; Karnbach, Geoffrey; Karoune, Emma; Keppler, Antje; Kleme
Opublikowane w:
EMBO journal, 2023, ISSN 1460-2075
Wydawca:
European Molecular Biology Organization
DOI:
10.15252/embj.2023115008
Autorzy:
Jessica M. Holsopple; Shannon R. Smoot; Ellen M. Popodi; John K. Colbourne; Joseph R. Shaw; Brian Oliver; Thomas C. Kaufman; Jason M. Tennessen
Opublikowane w:
JoVE, Numer 193, 2023, ISSN 1940-087X
Wydawca:
MYJoVE Corporation
DOI:
10.3791/65029
Autorzy:
Marvin Martens; Rob Stierum; Emma L. Schymanski; Chris T. Evelo; Reza Aalizadeh; Hristo Aladjov; Kasia Arturi; Karine Audouze; Pavel Babica; Karel Berka; Jos Bessems; Ludek Blaha; Evan E Bolton; Montserrat Cases; Dimitrios Damalas; Kirtan Dave; Marco Dilger; Thomas Exner; Daan P. Geerke; Roland C. Grafström; Alasdair J. G. Gray; John M. Hancock; Henner Hollert; Nina Jeliazkova; Danyel Jennen; Fab
Opublikowane w:
F1000Research, 2021, ISSN 2046-1402
Wydawca:
F1000 Research Ltd.
DOI:
10.12688/f1000research.74502.2
Autorzy:
Damir Baranasic; Matthias Hörtenhuber; Piotr J. Balwierz; Tobias Zehnder; Abdul Kadir Mukarram; Chirag Nepal; Csilla Várnai; Yavor Hadzhiev; Ada Jimenez-Gonzalez; Nan Li; Joseph Wragg; Fabio M. D’Orazio; Dorde Relic; Mikhail Pachkov; Noelia Díaz; Benjamín Hernández-Rodríguez; Zelin Chen; Marcus Stoiber; Michaël Dong; Irene Stevens; Samuel E. Ross; Anne Eagle; Ryan Martin; Oluwapelumi Obas
Opublikowane w:
Nature Genetics, Numer Volume 54, 2022, Strona(/y) 1037-1050, ISSN 1061-4036
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41588-022-01089-w
Autorzy:
Hayot, G., Marcato, D., Cramer von Clausbruch, C. A., Pace, G., Strähle, U., Colbourne, J. K., Pylatiuk, C., Peravali, R., Weiss, C., Scholz, S., Dickmeis, T.
Opublikowane w:
JoVE, 2024, ISSN 1940-087X
Wydawca:
MYJoVE Corporation
DOI:
10.3791/66153
Autorzy:
John K. Colbourne, Joseph R. Shaw, Elena Sostare, Claudia Rivetti, Romain Derelle, Rosemary Barnett, Bruno Campos, Carlie LaLone, Mark R. Viant, Geoff Hodges,
Opublikowane w:
Environmental Advances, Numer Volume 9, 2022, ISSN 2666-7657
Wydawca:
Elsevier BV
DOI:
10.1016/j.envadv.2022.100287
Autorzy:
Wilkinson, Mark D.; Sansone, Susanna-Assunta; Méndez, Eva; David, Romain; Dennis, Richard; Hecker, David; Kleemola, Mari; Lacagnina, Carlo; Nikiforova, Anastasija; Castro, Leyla Jael
Opublikowane w:
Open Research Europe, 2023, ISSN 2732-5121
Wydawca:
F1000 Research Limited on behalf of the European Commission
DOI:
10.12688/openreseurope.15364.1
Autorzy:
Escher, Beate I; Altenburger, Rolf; Blüher, Matthias; Colbourne, John K; Ebinghaus, Ralf; Fantke, Peter; Hein, Michaela; Köck, Wolfgang; Kümmerer, Klaus; Leipold, Sina; Li, Xiaojing; Scheringer, Martin; Scholz, Stefan; Schloter, Michael; Schweizer, Pia-Johanna; Tal, Tamara; Tetko, Igor; Traidl-Hoffmann, Claudia; Wick, Lukas Y; Fenner, Kathrin
Opublikowane w:
Archives of Toxicology, Numer Volume 97, 2023, Strona(/y) 1267-1283, ISSN 0340-5761
Wydawca:
Springer Verlag
DOI:
10.1007/s00204-023-03485-5
Autorzy:
Aleksandra Cavoski, John Colbourne, Laura Holden, Robert Lee
Opublikowane w:
Bio-Science Law Review, Numer Volume 19, Numer 3, 2024, Strona(/y) 101-107, ISSN 1365-8867
Wydawca:
Lawtext Publishing Ltd
Autorzy:
Muhammad Abdullahi, Xiaojing Li*, Mohamed Abou-Elwafa Abdallah, William Stubbings, Norman Yan, Marianne Barnard, Liang-Hong Guo, John K. Colbourne, and Luisa Orsini
Opublikowane w:
Environmental Science & Technology, 2022, ISSN 0013-936X
Wydawca:
American Chemical Society
DOI:
10.1021/acs.est.2c01799
Autorzy:
Philippe Rocca-Serra; Wei Gu; Vassilios Ioannidis; Tooba Abbassi Daloii; Salvador Capella-Gutierrez; Ishwar Chandramouliswaran; Andrea Splendiani; Tony Burdett; Robert T. Giessmann; David Henderson; Dominique Batista; Allyson Lister; Ibrahim Emam; Yojana Gadiya; Lucas Giovanni; Egon Willighagen; Chris Evelo; Alasdair J. G. Gray; Philip Gribbon; Nick Juty; Danielle Welter; Karsten Quast; Paul Peete
Opublikowane w:
Scientific Data, 2023, ISSN 2052-4463
Wydawca:
Springer Nature
DOI:
10.1038/s41597-023-02166-3
Autorzy:
Matthew D. Rand, Jason M. Tennessen, Trudy F. C. Mackay, Robert R. H. Anholt
Opublikowane w:
Current Protocols, 2023, ISSN 2691-1299
Wydawca:
Wiley
DOI:
10.1002/cpz1.870
Autorzy:
The PrecisionTox Consortium
Opublikowane w:
Toxicology Letters, Numer Volume 383, 2023, Strona(/y) 33-42, ISSN 0378-4274
Wydawca:
Elsevier BV
DOI:
10.1016/j.toxlet.2023.05.004
Autorzy:
Anurag Chaturvedi; Xiaojing Li; Vignesh Dhandapani; Hollie Marshall; Stephen Kissane; Maria Cuenca-Cambronero; Giovanni Asole; Ferriol Calvet; Marina Ruiz-Romero; Paolo Marangio; Roderic Guigó; Daria Rago; Leda Mirbahai; Niamh Eastwood; John K Colbourne; Jiarui Zhou; Eamonn Mallon; Luisa Orsini
Opublikowane w:
Nucleic Acids Research, Numer Volume 51, Numer 18, 2023, Strona(/y) 9785-9803, ISSN 1096-6080
Wydawca:
Oxford University Press
DOI:
10.1093/nar/gkad685
Autorzy:
Batista, Dominique; Jones, Martin; Weber, Ralf; Rocca-Serra, Philippe; Sansone, Susanna-Assunta
Opublikowane w:
2023
Wydawca:
Zenodo
DOI:
10.5281/zenodo.7847620
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