Toward Precision Toxicology: New Approach Methodologies for Chemical Safety

Projektinformationen

PrecisionTox

ID Finanzhilfevereinbarung: 965406

DOI

10.3030/965406

EK-Unterschriftsdatum 29 Januar 2021

Startdatum 1 Februar 2021

Enddatum 31 Juli 2026

Finanziert unter

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Gesamtkosten

€ 19 305 583,75

EU-Beitrag

€ 19 305 583,75

Koordiniert durch

THE UNIVERSITY OF BIRMINGHAM
United Kingdom

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (6)

Stakeholder-driven priorities document published by SAG

We will take advantage of our first kickoff meeting to elaborate the report to highlight SAG roles in developing longterm project applications and bring their own sectors and organisations priorities in line with the overall PrecisionTox goal and Project objectives

Shortlist of exploitation options for industry usage of NAM biomarkers

This deliverable maps those areas of EU law in which forms of chemical risk assessment are mandated or encouraged. Producing this overview of the relevant regulatory settings enables an analysis of the functionality of NAM biomarkers and their capacity to deliver on regulatory imperatives. We would envision a web based tool that would assist both researchers and regulatory agencies to locate appropriate settings for NAM biomarkers.

Protocols for routine and higher-throughput processing of experimental samples for multi-omics analysis

Written Standard Operating Protocols will be written that are version controlled and that provide a stepbystep set of instructions on how to conduct automated and highthroughput extractions for RNA and metabolite analysis for each of the NSOs and human cell lines A detailed description on how to incorporate a beadbased tissue and cell homogeniser and stateoftheart liquid handling robotics will be included

First loaded database and associated schema

First version of the central database for the PrecisionTox project will be created for the purposes of managing all of the data produced by or used by the consortium This database will allow fast and relevant queries by defining links between chemicals genesproteins phenotypes and all of the associated information that can be obtained from existing external sources In addition to simple textbased queries it will offer sequence eg BLAST and chemoinformatics eg Open Babel RDKit CDK searches

Report on socio-technical barriers to the take up of NAMs

This report addresses factors which may inhibit the take-up on NAMs. Such factors are not merely technical but involve a range of social, economic and political factors that may create path dependency on existing methods and even resistance to transition. The socio-technical analysis explores how co-production of NAMs through multidimensional engagement around industrial imperatives, market behaviours, chemicals policy, civil society perspectives and technological innovation may help embed NAMs into the fabric of chemical risk assessment.

Project website

We will first explore alternatives for web frameworks, consult graphic designers and launch the website with content by M3. The website will include a presentation of the project objectives and partners, a repository for open access peer reviewed publication (subject to dissemination permissions from the Project), newsletters, links to partners websites, regular updates regarding the project developments and activities (events, webinars), and will embed videos, podcasts, articles and press releases.

Open Research Data Pilot (1)

Data Management Plan

Written Data Management Plan DMP that incorporates the outputs of the WPs following H2020 project guidelines defining a strategy that ensures findability accessibility interoperability and reusability of all digital asset ensuring FAIRness in all phases of the data life cycle ie data generation curation storage processing handling metadata and dissemination of and access to the project data The report will document the data format specifications terminologies and data repositories vetted by the community and relevant to the project A first initial plan will be formulated at month 12 and the final version of the PrecisionTox Data Management Plan will be made available at month 36

Other (1)

Data submission to Data Commons (WP5) with response profiles for 50 chemicals

All phenotypic measurement data (except for the omics data that is generated and described in WP3) – for the first 50 test chemicals – will be reported to the Data Commons. This will include cytotoxicity data, measurements of embryo toxicity and teratology, measurements of endocrine disruption endpoints, cardiotoxicity and photomotor and other motor behaviours.

Veröffentlichungen

Other (2)

A web-based histology atlas for the freshwater crustacean<i>Daphnia magna</i>

Autoren: Mee S. Ngu; Daniel J. Vanselow; Carolyn R. Zaino; Debra A. Shearer; Chadwick Harris; Maksim A. Yakovlev; Spencer R. Katz; Alex Y. Lin; Jean E. Copper; Dula Parkinson; Margaret J. Beaton; John K. Colbourne; Keith C. Cheng; Khai C. Ang
Veröffentlicht in: 2022
Herausgeber: bioRxiv
DOI: 10.1101/2022.03.09.483544

The herbicide acetochlor causes lipid peroxidation by inhibition of glutathione peroxidase 4

Autoren: Fahmi Mesmar, Maram Muhsen, Jason P. Tourigny, Jason M. Tennessen, Maria Bondesson
Veröffentlicht in: 2023
Herausgeber: bioRxiv
DOI: 10.1101/2023.04.14.536563

Peer reviewed articles (16)

Zebrafish regulatory genomic resources for disease modelling and regeneration

Autoren: Ada Jimenez Gonzalez; Damir Baranasic; Ferenc Müller
Veröffentlicht in: Disease Models & Mechanisms, Ausgabe Volume 16, Ausgabe 8, 2023, ISSN 1754-8411
Herausgeber: Company of Biologists
DOI: 10.1242/dmm.050280

Reactivity of Acrylamides Causes Cytotoxicity and Activates Oxidative Stress Response

Autoren: Julia Huchthausen, Beate I. Escher*, Nico Grasse, Maria König, Stephan Beil, and Luise Henneberger
Veröffentlicht in: Chemical Research in Toxicology, Ausgabe Volume 36, 2023, Seite(n) 1374-1385, ISSN 0893-228X
Herausgeber: American Chemical Society
DOI: 10.1021/acs.chemrestox.3c00115

"Preprint: ""Be Sustainable Recommendations"" for FAIR Resources in Life Sciences research: EOSC-Life's Lessons"

Autoren: David, Romain; Rybina, Arina; Burel, Jean-Marie; Heriche, Jean-Karim; Audergon, Pauline; Boiten, Jan-Willem; Coppens, Frederik; Crockett, Sara; Exter Katrina; Fahrener, Sven; Fratelli, Maddalena; Goble, Carole; Gormanns, Philipp; Grantner, Tobias; Gruning, Bjorn; Gurwitz, Kim Tamara; Hancock, John; Harmse, Henriette; Holub, Petr; Juty, Nick; Karnbach, Geoffrey; Karoune, Emma; Keppler, Antje; Kleme
Veröffentlicht in: EMBO journal, 2023, ISSN 1460-2075
Herausgeber: European Molecular Biology Organization
DOI: 10.15252/embj.2023115008

Assessment of Chemical Toxicity in Adult &lt;em&gt;Drosophila Melanogaster&lt;/em&gt;

Autoren: Jessica M. Holsopple; Shannon R. Smoot; Ellen M. Popodi; John K. Colbourne; Joseph R. Shaw; Brian Oliver; Thomas C. Kaufman; Jason M. Tennessen
Veröffentlicht in: JoVE, Ausgabe 193, 2023, ISSN 1940-087X
Herausgeber: MYJoVE Corporation
DOI: 10.3791/65029

ELIXIR and Toxicology: a community in development

Autoren: Marvin Martens; Rob Stierum; Emma L. Schymanski; Chris T. Evelo; Reza Aalizadeh; Hristo Aladjov; Kasia Arturi; Karine Audouze; Pavel Babica; Karel Berka; Jos Bessems; Ludek Blaha; Evan E Bolton; Montserrat Cases; Dimitrios Damalas; Kirtan Dave; Marco Dilger; Thomas Exner; Daan P. Geerke; Roland C. Grafström; Alasdair J. G. Gray; John M. Hancock; Henner Hollert; Nina Jeliazkova; Danyel Jennen; Fab
Veröffentlicht in: F1000Research, 2021, ISSN 2046-1402
Herausgeber: F1000 Research Ltd.
DOI: 10.12688/f1000research.74502.2

Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements

Autoren: Damir Baranasic; Matthias Hörtenhuber; Piotr J. Balwierz; Tobias Zehnder; Abdul Kadir Mukarram; Chirag Nepal; Csilla Várnai; Yavor Hadzhiev; Ada Jimenez-Gonzalez; Nan Li; Joseph Wragg; Fabio M. D’Orazio; Dorde Relic; Mikhail Pachkov; Noelia Díaz; Benjamín Hernández-Rodríguez; Zelin Chen; Marcus Stoiber; Michaël Dong; Irene Stevens; Samuel E. Ross; Anne Eagle; Ryan Martin; Oluwapelumi Obas
Veröffentlicht in: Nature Genetics, Ausgabe Volume 54, 2022, Seite(n) 1037-1050, ISSN 1061-4036
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41588-022-01089-w

Evaluating Toxicity of Chemicals using a Zebrafish Vibration Startle Response Screening System

Autoren: Hayot, G., Marcato, D., Cramer von Clausbruch, C. A., Pace, G., Strähle, U., Colbourne, J. K., Pylatiuk, C., Peravali, R., Weiss, C., Scholz, S., Dickmeis, T.
Veröffentlicht in: JoVE, 2024, ISSN 1940-087X
Herausgeber: MYJoVE Corporation
DOI: 10.3791/66153

Toxicity by descent: A comparative approach for chemical hazard assessment

Autoren: John K. Colbourne, Joseph R. Shaw, Elena Sostare, Claudia Rivetti, Romain Derelle, Rosemary Barnett, Bruno Campos, Carlie LaLone, Mark R. Viant, Geoff Hodges,
Veröffentlicht in: Environmental Advances, Ausgabe Volume 9, 2022, ISSN 2666-7657
Herausgeber: Elsevier BV
DOI: 10.1016/j.envadv.2022.100287

Community-driven governance of FAIRness assessment: an open issue, an open discussion

Autoren: Wilkinson, Mark D.; Sansone, Susanna-Assunta; Méndez, Eva; David, Romain; Dennis, Richard; Hecker, David; Kleemola, Mari; Lacagnina, Carlo; Nikiforova, Anastasija; Castro, Leyla Jael
Veröffentlicht in: Open Research Europe, 2023, ISSN 2732-5121
Herausgeber: F1000 Research Limited on behalf of the European Commission
DOI: 10.12688/openreseurope.15364.1

Modernizing persistence–bioaccumulation–toxicity (PBT) assessment with high throughput animal-free methods

Autoren: Escher, Beate I; Altenburger, Rolf; Blüher, Matthias; Colbourne, John K; Ebinghaus, Ralf; Fantke, Peter; Hein, Michaela; Köck, Wolfgang; Kümmerer, Klaus; Leipold, Sina; Li, Xiaojing; Scheringer, Martin; Scholz, Stefan; Schloter, Michael; Schweizer, Pia-Johanna; Tal, Tamara; Tetko, Igor; Traidl-Hoffmann, Claudia; Wick, Lukas Y; Fenner, Kathrin
Veröffentlicht in: Archives of Toxicology, Ausgabe Volume 97, 2023, Seite(n) 1267-1283, ISSN 0340-5761
Herausgeber: Springer Verlag
DOI: 10.1007/s00204-023-03485-5

Precision toxicology: new approach methodologies for chemical safety

Autoren: Aleksandra Cavoski, John Colbourne, Laura Holden, Robert Lee
Veröffentlicht in: Bio-Science Law Review, Ausgabe Volume 19, Ausgabe 3, 2024, Seite(n) 101-107, ISSN 1365-8867
Herausgeber: Lawtext Publishing Ltd

Daphnia as a Sentinel Species for Environmental Health Protection: A Perspective on Biomonitoring and Bioremediation of Chemical Pollution

Autoren: Muhammad Abdullahi, Xiaojing Li*, Mohamed Abou-Elwafa Abdallah, William Stubbings, Norman Yan, Marianne Barnard, Liang-Hong Guo, John K. Colbourne, and Luisa Orsini
Veröffentlicht in: Environmental Science & Technology, 2022, ISSN 0013-936X
Herausgeber: American Chemical Society
DOI: 10.1021/acs.est.2c01799

The FAIR Cookbook - the essential resource for and by FAIR doers

Autoren: Philippe Rocca-Serra; Wei Gu; Vassilios Ioannidis; Tooba Abbassi Daloii; Salvador Capella-Gutierrez; Ishwar Chandramouliswaran; Andrea Splendiani; Tony Burdett; Robert T. Giessmann; David Henderson; Dominique Batista; Allyson Lister; Ibrahim Emam; Yojana Gadiya; Lucas Giovanni; Egon Willighagen; Chris Evelo; Alasdair J. G. Gray; Philip Gribbon; Nick Juty; Danielle Welter; Karsten Quast; Paul Peete
Veröffentlicht in: Scientific Data, 2023, ISSN 2052-4463
Herausgeber: Springer Nature
DOI: 10.1038/s41597-023-02166-3

Perspectives on the Drosophila melanogaster Model for Advances in Toxicological Science

Autoren: Matthew D. Rand, Jason M. Tennessen, Trudy F. C. Mackay, Robert R. H. Anholt
Veröffentlicht in: Current Protocols, 2023, ISSN 2691-1299
Herausgeber: Wiley
DOI: 10.1002/cpz1.870

The Precision Toxicology initiative

Autoren: The PrecisionTox Consortium
Veröffentlicht in: Toxicology Letters, Ausgabe Volume 383, 2023, Seite(n) 33-42, ISSN 0378-4274
Herausgeber: Elsevier BV
DOI: 10.1016/j.toxlet.2023.05.004

The hologenome of <i>Daphnia magna</i> reveals possible DNA methylation and microbiome-mediated evolution of the host genome

Autoren: Anurag Chaturvedi; Xiaojing Li; Vignesh Dhandapani; Hollie Marshall; Stephen Kissane; Maria Cuenca-Cambronero; Giovanni Asole; Ferriol Calvet; Marina Ruiz-Romero; Paolo Marangio; Roderic Guigó; Daria Rago; Leda Mirbahai; Niamh Eastwood; John K Colbourne; Jiarui Zhou; Eamonn Mallon; Luisa Orsini
Veröffentlicht in: Nucleic Acids Research, Ausgabe Volume 51, Ausgabe 18, 2023, Seite(n) 9785-9803, ISSN 1096-6080
Herausgeber: Oxford University Press
DOI: 10.1093/nar/gkad685

Conference proceedings (1)

FAIR by design: study design-driven creation of standards compliant metadata

Autoren: Batista, Dominique; Jones, Martin; Weber, Ralf; Rocca-Serra, Philippe; Sansone, Susanna-Assunta
Veröffentlicht in: 2023
Herausgeber: Zenodo
DOI: 10.5281/zenodo.7847620