CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.
I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .
Risultati finali
We will take advantage of our first kickoff meeting to elaborate the report to highlight SAG roles in developing longterm project applications and bring their own sectors and organisations priorities in line with the overall PrecisionTox goal and Project objectives
Shortlist of exploitation options for industry usage of NAM biomarkers (si apre in una nuova finestra)This deliverable maps those areas of EU law in which forms of chemical risk assessment are mandated or encouraged. Producing this overview of the relevant regulatory settings enables an analysis of the functionality of NAM biomarkers and their capacity to deliver on regulatory imperatives. We would envision a web based tool that would assist both researchers and regulatory agencies to locate appropriate settings for NAM biomarkers.
Protocols for routine and higher-throughput processing of experimental samples for multi-omics analysis (si apre in una nuova finestra)Written Standard Operating Protocols will be written that are version controlled and that provide a stepbystep set of instructions on how to conduct automated and highthroughput extractions for RNA and metabolite analysis for each of the NSOs and human cell lines A detailed description on how to incorporate a beadbased tissue and cell homogeniser and stateoftheart liquid handling robotics will be included
First loaded database and associated schema (si apre in una nuova finestra)First version of the central database for the PrecisionTox project will be created for the purposes of managing all of the data produced by or used by the consortium This database will allow fast and relevant queries by defining links between chemicals genesproteins phenotypes and all of the associated information that can be obtained from existing external sources In addition to simple textbased queries it will offer sequence eg BLAST and chemoinformatics eg Open Babel RDKit CDK searches
Report on socio-technical barriers to the take up of NAMs (si apre in una nuova finestra)This report addresses factors which may inhibit the take-up on NAMs. Such factors are not merely technical but involve a range of social, economic and political factors that may create path dependency on existing methods and even resistance to transition. The socio-technical analysis explores how co-production of NAMs through multidimensional engagement around industrial imperatives, market behaviours, chemicals policy, civil society perspectives and technological innovation may help embed NAMs into the fabric of chemical risk assessment.
Project website (si apre in una nuova finestra)We will first explore alternatives for web frameworks, consult graphic designers and launch the website with content by M3. The website will include a presentation of the project objectives and partners, a repository for open access peer reviewed publication (subject to dissemination permissions from the Project), newsletters, links to partners websites, regular updates regarding the project developments and activities (events, webinars), and will embed videos, podcasts, articles and press releases.
Written Data Management Plan DMP that incorporates the outputs of the WPs following H2020 project guidelines defining a strategy that ensures findability accessibility interoperability and reusability of all digital asset ensuring FAIRness in all phases of the data life cycle ie data generation curation storage processing handling metadata and dissemination of and access to the project data The report will document the data format specifications terminologies and data repositories vetted by the community and relevant to the project A first initial plan will be formulated at month 12 and the final version of the PrecisionTox Data Management Plan will be made available at month 36
All phenotypic measurement data (except for the omics data that is generated and described in WP3) – for the first 50 test chemicals – will be reported to the Data Commons. This will include cytotoxicity data, measurements of embryo toxicity and teratology, measurements of endocrine disruption endpoints, cardiotoxicity and photomotor and other motor behaviours.
Pubblicazioni
Autori:
Mee S. Ngu; Daniel J. Vanselow; Carolyn R. Zaino; Debra A. Shearer; Chadwick Harris; Maksim A. Yakovlev; Spencer R. Katz; Alex Y. Lin; Jean E. Copper; Dula Parkinson; Margaret J. Beaton; John K. Colbourne; Keith C. Cheng; Khai C. Ang
Pubblicato in:
2022
Editore:
bioRxiv
DOI:
10.1101/2022.03.09.483544
Autori:
Fahmi Mesmar, Maram Muhsen, Jason P. Tourigny, Jason M. Tennessen, Maria Bondesson
Pubblicato in:
2023
Editore:
bioRxiv
DOI:
10.1101/2023.04.14.536563
Autori:
Ada Jimenez Gonzalez; Damir Baranasic; Ferenc Müller
Pubblicato in:
Disease Models & Mechanisms, Numero Volume 16, Numero 8, 2023, ISSN 1754-8411
Editore:
Company of Biologists
DOI:
10.1242/dmm.050280
Autori:
Julia Huchthausen, Beate I. Escher*, Nico Grasse, Maria König, Stephan Beil, and Luise Henneberger
Pubblicato in:
Chemical Research in Toxicology, Numero Volume 36, 2023, Pagina/e 1374-1385, ISSN 0893-228X
Editore:
American Chemical Society
DOI:
10.1021/acs.chemrestox.3c00115
Autori:
David, Romain; Rybina, Arina; Burel, Jean-Marie; Heriche, Jean-Karim; Audergon, Pauline; Boiten, Jan-Willem; Coppens, Frederik; Crockett, Sara; Exter Katrina; Fahrener, Sven; Fratelli, Maddalena; Goble, Carole; Gormanns, Philipp; Grantner, Tobias; Gruning, Bjorn; Gurwitz, Kim Tamara; Hancock, John; Harmse, Henriette; Holub, Petr; Juty, Nick; Karnbach, Geoffrey; Karoune, Emma; Keppler, Antje; Kleme
Pubblicato in:
EMBO journal, 2023, ISSN 1460-2075
Editore:
European Molecular Biology Organization
DOI:
10.15252/embj.2023115008
Autori:
Jessica M. Holsopple; Shannon R. Smoot; Ellen M. Popodi; John K. Colbourne; Joseph R. Shaw; Brian Oliver; Thomas C. Kaufman; Jason M. Tennessen
Pubblicato in:
JoVE, Numero 193, 2023, ISSN 1940-087X
Editore:
MYJoVE Corporation
DOI:
10.3791/65029
Autori:
Marvin Martens; Rob Stierum; Emma L. Schymanski; Chris T. Evelo; Reza Aalizadeh; Hristo Aladjov; Kasia Arturi; Karine Audouze; Pavel Babica; Karel Berka; Jos Bessems; Ludek Blaha; Evan E Bolton; Montserrat Cases; Dimitrios Damalas; Kirtan Dave; Marco Dilger; Thomas Exner; Daan P. Geerke; Roland C. Grafström; Alasdair J. G. Gray; John M. Hancock; Henner Hollert; Nina Jeliazkova; Danyel Jennen; Fab
Pubblicato in:
F1000Research, 2021, ISSN 2046-1402
Editore:
F1000 Research Ltd.
DOI:
10.12688/f1000research.74502.2
Autori:
Damir Baranasic; Matthias Hörtenhuber; Piotr J. Balwierz; Tobias Zehnder; Abdul Kadir Mukarram; Chirag Nepal; Csilla Várnai; Yavor Hadzhiev; Ada Jimenez-Gonzalez; Nan Li; Joseph Wragg; Fabio M. D’Orazio; Dorde Relic; Mikhail Pachkov; Noelia Díaz; Benjamín Hernández-Rodríguez; Zelin Chen; Marcus Stoiber; Michaël Dong; Irene Stevens; Samuel E. Ross; Anne Eagle; Ryan Martin; Oluwapelumi Obas
Pubblicato in:
Nature Genetics, Numero Volume 54, 2022, Pagina/e 1037-1050, ISSN 1061-4036
Editore:
Nature Publishing Group
DOI:
10.1038/s41588-022-01089-w
Autori:
Hayot, G., Marcato, D., Cramer von Clausbruch, C. A., Pace, G., Strähle, U., Colbourne, J. K., Pylatiuk, C., Peravali, R., Weiss, C., Scholz, S., Dickmeis, T.
Pubblicato in:
JoVE, 2024, ISSN 1940-087X
Editore:
MYJoVE Corporation
DOI:
10.3791/66153
Autori:
John K. Colbourne, Joseph R. Shaw, Elena Sostare, Claudia Rivetti, Romain Derelle, Rosemary Barnett, Bruno Campos, Carlie LaLone, Mark R. Viant, Geoff Hodges,
Pubblicato in:
Environmental Advances, Numero Volume 9, 2022, ISSN 2666-7657
Editore:
Elsevier BV
DOI:
10.1016/j.envadv.2022.100287
Autori:
Wilkinson, Mark D.; Sansone, Susanna-Assunta; Méndez, Eva; David, Romain; Dennis, Richard; Hecker, David; Kleemola, Mari; Lacagnina, Carlo; Nikiforova, Anastasija; Castro, Leyla Jael
Pubblicato in:
Open Research Europe, 2023, ISSN 2732-5121
Editore:
F1000 Research Limited on behalf of the European Commission
DOI:
10.12688/openreseurope.15364.1
Autori:
Escher, Beate I; Altenburger, Rolf; Blüher, Matthias; Colbourne, John K; Ebinghaus, Ralf; Fantke, Peter; Hein, Michaela; Köck, Wolfgang; Kümmerer, Klaus; Leipold, Sina; Li, Xiaojing; Scheringer, Martin; Scholz, Stefan; Schloter, Michael; Schweizer, Pia-Johanna; Tal, Tamara; Tetko, Igor; Traidl-Hoffmann, Claudia; Wick, Lukas Y; Fenner, Kathrin
Pubblicato in:
Archives of Toxicology, Numero Volume 97, 2023, Pagina/e 1267-1283, ISSN 0340-5761
Editore:
Springer Verlag
DOI:
10.1007/s00204-023-03485-5
Autori:
Aleksandra Cavoski, John Colbourne, Laura Holden, Robert Lee
Pubblicato in:
Bio-Science Law Review, Numero Volume 19, Numero 3, 2024, Pagina/e 101-107, ISSN 1365-8867
Editore:
Lawtext Publishing Ltd
Autori:
Muhammad Abdullahi, Xiaojing Li*, Mohamed Abou-Elwafa Abdallah, William Stubbings, Norman Yan, Marianne Barnard, Liang-Hong Guo, John K. Colbourne, and Luisa Orsini
Pubblicato in:
Environmental Science & Technology, 2022, ISSN 0013-936X
Editore:
American Chemical Society
DOI:
10.1021/acs.est.2c01799
Autori:
Philippe Rocca-Serra; Wei Gu; Vassilios Ioannidis; Tooba Abbassi Daloii; Salvador Capella-Gutierrez; Ishwar Chandramouliswaran; Andrea Splendiani; Tony Burdett; Robert T. Giessmann; David Henderson; Dominique Batista; Allyson Lister; Ibrahim Emam; Yojana Gadiya; Lucas Giovanni; Egon Willighagen; Chris Evelo; Alasdair J. G. Gray; Philip Gribbon; Nick Juty; Danielle Welter; Karsten Quast; Paul Peete
Pubblicato in:
Scientific Data, 2023, ISSN 2052-4463
Editore:
Springer Nature
DOI:
10.1038/s41597-023-02166-3
Autori:
Matthew D. Rand, Jason M. Tennessen, Trudy F. C. Mackay, Robert R. H. Anholt
Pubblicato in:
Current Protocols, 2023, ISSN 2691-1299
Editore:
Wiley
DOI:
10.1002/cpz1.870
Autori:
The PrecisionTox Consortium
Pubblicato in:
Toxicology Letters, Numero Volume 383, 2023, Pagina/e 33-42, ISSN 0378-4274
Editore:
Elsevier BV
DOI:
10.1016/j.toxlet.2023.05.004
Autori:
Anurag Chaturvedi; Xiaojing Li; Vignesh Dhandapani; Hollie Marshall; Stephen Kissane; Maria Cuenca-Cambronero; Giovanni Asole; Ferriol Calvet; Marina Ruiz-Romero; Paolo Marangio; Roderic Guigó; Daria Rago; Leda Mirbahai; Niamh Eastwood; John K Colbourne; Jiarui Zhou; Eamonn Mallon; Luisa Orsini
Pubblicato in:
Nucleic Acids Research, Numero Volume 51, Numero 18, 2023, Pagina/e 9785-9803, ISSN 1096-6080
Editore:
Oxford University Press
DOI:
10.1093/nar/gkad685
Autori:
Batista, Dominique; Jones, Martin; Weber, Ralf; Rocca-Serra, Philippe; Sansone, Susanna-Assunta
Pubblicato in:
2023
Editore:
Zenodo
DOI:
10.5281/zenodo.7847620
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