CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.
Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .
Livrables
We will take advantage of our first kickoff meeting to elaborate the report to highlight SAG roles in developing longterm project applications and bring their own sectors and organisations priorities in line with the overall PrecisionTox goal and Project objectives
Shortlist of exploitation options for industry usage of NAM biomarkers (s’ouvre dans une nouvelle fenêtre)This deliverable maps those areas of EU law in which forms of chemical risk assessment are mandated or encouraged. Producing this overview of the relevant regulatory settings enables an analysis of the functionality of NAM biomarkers and their capacity to deliver on regulatory imperatives. We would envision a web based tool that would assist both researchers and regulatory agencies to locate appropriate settings for NAM biomarkers.
Protocols for routine and higher-throughput processing of experimental samples for multi-omics analysis (s’ouvre dans une nouvelle fenêtre)Written Standard Operating Protocols will be written that are version controlled and that provide a stepbystep set of instructions on how to conduct automated and highthroughput extractions for RNA and metabolite analysis for each of the NSOs and human cell lines A detailed description on how to incorporate a beadbased tissue and cell homogeniser and stateoftheart liquid handling robotics will be included
First loaded database and associated schema (s’ouvre dans une nouvelle fenêtre)First version of the central database for the PrecisionTox project will be created for the purposes of managing all of the data produced by or used by the consortium This database will allow fast and relevant queries by defining links between chemicals genesproteins phenotypes and all of the associated information that can be obtained from existing external sources In addition to simple textbased queries it will offer sequence eg BLAST and chemoinformatics eg Open Babel RDKit CDK searches
Report on socio-technical barriers to the take up of NAMs (s’ouvre dans une nouvelle fenêtre)This report addresses factors which may inhibit the take-up on NAMs. Such factors are not merely technical but involve a range of social, economic and political factors that may create path dependency on existing methods and even resistance to transition. The socio-technical analysis explores how co-production of NAMs through multidimensional engagement around industrial imperatives, market behaviours, chemicals policy, civil society perspectives and technological innovation may help embed NAMs into the fabric of chemical risk assessment.
Project website (s’ouvre dans une nouvelle fenêtre)We will first explore alternatives for web frameworks, consult graphic designers and launch the website with content by M3. The website will include a presentation of the project objectives and partners, a repository for open access peer reviewed publication (subject to dissemination permissions from the Project), newsletters, links to partners websites, regular updates regarding the project developments and activities (events, webinars), and will embed videos, podcasts, articles and press releases.
Written Data Management Plan DMP that incorporates the outputs of the WPs following H2020 project guidelines defining a strategy that ensures findability accessibility interoperability and reusability of all digital asset ensuring FAIRness in all phases of the data life cycle ie data generation curation storage processing handling metadata and dissemination of and access to the project data The report will document the data format specifications terminologies and data repositories vetted by the community and relevant to the project A first initial plan will be formulated at month 12 and the final version of the PrecisionTox Data Management Plan will be made available at month 36
All phenotypic measurement data (except for the omics data that is generated and described in WP3) – for the first 50 test chemicals – will be reported to the Data Commons. This will include cytotoxicity data, measurements of embryo toxicity and teratology, measurements of endocrine disruption endpoints, cardiotoxicity and photomotor and other motor behaviours.
Publications
Auteurs:
Mee S. Ngu; Daniel J. Vanselow; Carolyn R. Zaino; Debra A. Shearer; Chadwick Harris; Maksim A. Yakovlev; Spencer R. Katz; Alex Y. Lin; Jean E. Copper; Dula Parkinson; Margaret J. Beaton; John K. Colbourne; Keith C. Cheng; Khai C. Ang
Publié dans:
2022
Éditeur:
bioRxiv
DOI:
10.1101/2022.03.09.483544
Auteurs:
Fahmi Mesmar, Maram Muhsen, Jason P. Tourigny, Jason M. Tennessen, Maria Bondesson
Publié dans:
2023
Éditeur:
bioRxiv
DOI:
10.1101/2023.04.14.536563
Auteurs:
Ada Jimenez Gonzalez; Damir Baranasic; Ferenc Müller
Publié dans:
Disease Models & Mechanisms, Numéro Volume 16, Numéro 8, 2023, ISSN 1754-8411
Éditeur:
Company of Biologists
DOI:
10.1242/dmm.050280
Auteurs:
Julia Huchthausen, Beate I. Escher*, Nico Grasse, Maria König, Stephan Beil, and Luise Henneberger
Publié dans:
Chemical Research in Toxicology, Numéro Volume 36, 2023, Page(s) 1374-1385, ISSN 0893-228X
Éditeur:
American Chemical Society
DOI:
10.1021/acs.chemrestox.3c00115
Auteurs:
David, Romain; Rybina, Arina; Burel, Jean-Marie; Heriche, Jean-Karim; Audergon, Pauline; Boiten, Jan-Willem; Coppens, Frederik; Crockett, Sara; Exter Katrina; Fahrener, Sven; Fratelli, Maddalena; Goble, Carole; Gormanns, Philipp; Grantner, Tobias; Gruning, Bjorn; Gurwitz, Kim Tamara; Hancock, John; Harmse, Henriette; Holub, Petr; Juty, Nick; Karnbach, Geoffrey; Karoune, Emma; Keppler, Antje; Kleme
Publié dans:
EMBO journal, 2023, ISSN 1460-2075
Éditeur:
European Molecular Biology Organization
DOI:
10.15252/embj.2023115008
Auteurs:
Jessica M. Holsopple; Shannon R. Smoot; Ellen M. Popodi; John K. Colbourne; Joseph R. Shaw; Brian Oliver; Thomas C. Kaufman; Jason M. Tennessen
Publié dans:
JoVE, Numéro 193, 2023, ISSN 1940-087X
Éditeur:
MYJoVE Corporation
DOI:
10.3791/65029
Auteurs:
Marvin Martens; Rob Stierum; Emma L. Schymanski; Chris T. Evelo; Reza Aalizadeh; Hristo Aladjov; Kasia Arturi; Karine Audouze; Pavel Babica; Karel Berka; Jos Bessems; Ludek Blaha; Evan E Bolton; Montserrat Cases; Dimitrios Damalas; Kirtan Dave; Marco Dilger; Thomas Exner; Daan P. Geerke; Roland C. Grafström; Alasdair J. G. Gray; John M. Hancock; Henner Hollert; Nina Jeliazkova; Danyel Jennen; Fab
Publié dans:
F1000Research, 2021, ISSN 2046-1402
Éditeur:
F1000 Research Ltd.
DOI:
10.12688/f1000research.74502.2
Auteurs:
Damir Baranasic; Matthias Hörtenhuber; Piotr J. Balwierz; Tobias Zehnder; Abdul Kadir Mukarram; Chirag Nepal; Csilla Várnai; Yavor Hadzhiev; Ada Jimenez-Gonzalez; Nan Li; Joseph Wragg; Fabio M. D’Orazio; Dorde Relic; Mikhail Pachkov; Noelia Díaz; Benjamín Hernández-Rodríguez; Zelin Chen; Marcus Stoiber; Michaël Dong; Irene Stevens; Samuel E. Ross; Anne Eagle; Ryan Martin; Oluwapelumi Obas
Publié dans:
Nature Genetics, Numéro Volume 54, 2022, Page(s) 1037-1050, ISSN 1061-4036
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41588-022-01089-w
Auteurs:
Hayot, G., Marcato, D., Cramer von Clausbruch, C. A., Pace, G., Strähle, U., Colbourne, J. K., Pylatiuk, C., Peravali, R., Weiss, C., Scholz, S., Dickmeis, T.
Publié dans:
JoVE, 2024, ISSN 1940-087X
Éditeur:
MYJoVE Corporation
DOI:
10.3791/66153
Auteurs:
John K. Colbourne, Joseph R. Shaw, Elena Sostare, Claudia Rivetti, Romain Derelle, Rosemary Barnett, Bruno Campos, Carlie LaLone, Mark R. Viant, Geoff Hodges,
Publié dans:
Environmental Advances, Numéro Volume 9, 2022, ISSN 2666-7657
Éditeur:
Elsevier BV
DOI:
10.1016/j.envadv.2022.100287
Auteurs:
Wilkinson, Mark D.; Sansone, Susanna-Assunta; Méndez, Eva; David, Romain; Dennis, Richard; Hecker, David; Kleemola, Mari; Lacagnina, Carlo; Nikiforova, Anastasija; Castro, Leyla Jael
Publié dans:
Open Research Europe, 2023, ISSN 2732-5121
Éditeur:
F1000 Research Limited on behalf of the European Commission
DOI:
10.12688/openreseurope.15364.1
Auteurs:
Escher, Beate I; Altenburger, Rolf; Blüher, Matthias; Colbourne, John K; Ebinghaus, Ralf; Fantke, Peter; Hein, Michaela; Köck, Wolfgang; Kümmerer, Klaus; Leipold, Sina; Li, Xiaojing; Scheringer, Martin; Scholz, Stefan; Schloter, Michael; Schweizer, Pia-Johanna; Tal, Tamara; Tetko, Igor; Traidl-Hoffmann, Claudia; Wick, Lukas Y; Fenner, Kathrin
Publié dans:
Archives of Toxicology, Numéro Volume 97, 2023, Page(s) 1267-1283, ISSN 0340-5761
Éditeur:
Springer Verlag
DOI:
10.1007/s00204-023-03485-5
Auteurs:
Aleksandra Cavoski, John Colbourne, Laura Holden, Robert Lee
Publié dans:
Bio-Science Law Review, Numéro Volume 19, Numéro 3, 2024, Page(s) 101-107, ISSN 1365-8867
Éditeur:
Lawtext Publishing Ltd
Auteurs:
Muhammad Abdullahi, Xiaojing Li*, Mohamed Abou-Elwafa Abdallah, William Stubbings, Norman Yan, Marianne Barnard, Liang-Hong Guo, John K. Colbourne, and Luisa Orsini
Publié dans:
Environmental Science & Technology, 2022, ISSN 0013-936X
Éditeur:
American Chemical Society
DOI:
10.1021/acs.est.2c01799
Auteurs:
Philippe Rocca-Serra; Wei Gu; Vassilios Ioannidis; Tooba Abbassi Daloii; Salvador Capella-Gutierrez; Ishwar Chandramouliswaran; Andrea Splendiani; Tony Burdett; Robert T. Giessmann; David Henderson; Dominique Batista; Allyson Lister; Ibrahim Emam; Yojana Gadiya; Lucas Giovanni; Egon Willighagen; Chris Evelo; Alasdair J. G. Gray; Philip Gribbon; Nick Juty; Danielle Welter; Karsten Quast; Paul Peete
Publié dans:
Scientific Data, 2023, ISSN 2052-4463
Éditeur:
Springer Nature
DOI:
10.1038/s41597-023-02166-3
Auteurs:
Matthew D. Rand, Jason M. Tennessen, Trudy F. C. Mackay, Robert R. H. Anholt
Publié dans:
Current Protocols, 2023, ISSN 2691-1299
Éditeur:
Wiley
DOI:
10.1002/cpz1.870
Auteurs:
The PrecisionTox Consortium
Publié dans:
Toxicology Letters, Numéro Volume 383, 2023, Page(s) 33-42, ISSN 0378-4274
Éditeur:
Elsevier BV
DOI:
10.1016/j.toxlet.2023.05.004
Auteurs:
Anurag Chaturvedi; Xiaojing Li; Vignesh Dhandapani; Hollie Marshall; Stephen Kissane; Maria Cuenca-Cambronero; Giovanni Asole; Ferriol Calvet; Marina Ruiz-Romero; Paolo Marangio; Roderic Guigó; Daria Rago; Leda Mirbahai; Niamh Eastwood; John K Colbourne; Jiarui Zhou; Eamonn Mallon; Luisa Orsini
Publié dans:
Nucleic Acids Research, Numéro Volume 51, Numéro 18, 2023, Page(s) 9785-9803, ISSN 1096-6080
Éditeur:
Oxford University Press
DOI:
10.1093/nar/gkad685
Auteurs:
Batista, Dominique; Jones, Martin; Weber, Ralf; Rocca-Serra, Philippe; Sansone, Susanna-Assunta
Publié dans:
2023
Éditeur:
Zenodo
DOI:
10.5281/zenodo.7847620
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