Cel During mitosis of eucaryotic cells, the duplication and separation of the centrosome is crucial for proper chromosome segregation. I propose to characterize rosario, a Drosophila mitotic mutant identified in Pr. D. Glover's laboratory. Embryos laid by homozygous female for rosario fail to develop and show bipolar mitotic spindles nucleated by clusters of centrosomes. rosario mutants show centrosome separation defects without duplication failure, as well as chromatid separation defects at anaphase. I will determine whether the primary mitotic defect is in chromosome segregation or in centrosome separation, using real time observations. Furthermore, I will map the transcription units within an interval of 25kb of genomic DNA in which rosario lies and functionally identify rosario, by testing the ability of genomic fragments from this region to rescue the mutation following gerrn line transformation. Characterization of the rosario gene and its associated phenotype will help to understand relationships of the centrosome replication cycle to the process of chromosomes segregation. Dziedzina nauki nauki przyrodniczenauki biologicznegenetykaDNAnauki przyrodniczenauki biologicznegenetykamutacjanauki przyrodniczenauki biologicznegenetykachromosomymedycyna i nauki o zdrowiumedycyna klinicznaembriologia Program(-y) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Temat(-y) 0302 - Post-doctoral research training grants TL05 - Cell Biology Zaproszenie do składania wniosków Data not available System finansowania RGI - Research grants (individual fellowships) Koordynator University of Dundee Adres Smalls wynd DD1 4HN Dundee Zjednoczone Królestwo Zobacz na mapie Wkład UE € 0,00 Uczestnicy (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko Not available Francja Wkład UE € 0,00 Adres Zobacz na mapie
