Cel The coenzyme pyridoxal phosphate mediates in the catalysis of metabolic reactions of D- and L- amino acids. Although much work has been done on the mechanism of action and stereospecificity of these processes, it has been difficult to examine the intermediate stages because the substrates are processed so effectively. We therefore propose to synthesise stereospecifically labelled inhibitors of these enzymes and use them to study the overall mechanism of action of the reactions. This will involve isolation of enzyme-inhibitor complexes and trapping of enamine intermediates with thiols. The stereospecificity of formation of the Snackertz intermediate will also be studied. The use of these inhibitors will allow intimate details of the mechanism to be studied. The involvement of D-amino acids in bacterial metabolic processes makes the enzyme inhibitors of potential value as anti-bacterial drugs. Dziedzina nauki nauki przyrodniczenauki chemicznekatalizanauki przyrodniczenauki chemicznechemia organicznaaminynauki przyrodniczenauki biologicznebiochemiabiocząsteczkibiałkaenzymy Program(-y) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Temat(-y) 0302 - Post-doctoral research training grants TC03 - Biological, Medicinal and Pharmaceutical Chemistry Zaproszenie do składania wniosków Data not available System finansowania RGI - Research grants (individual fellowships) Koordynator University of Sussex Adres Falmer BN1 9QJ Brighton Zjednoczone Królestwo Zobacz na mapie Wkład UE € 0,00 Uczestnicy (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko Not available Irlandia Wkład UE € 0,00 Adres Zobacz na mapie
