Development of thermodynamically defined solid contact for polymer ion selective membranes and application of screen-printing technology for fabrication of miniature all-solid-state potentiometric sensors

Informacje na temat projektu

Identyfikator umowy o grant: INTAS-93-1418

Projekt został zamknięty

Data rozpoczęcia 1 Września 1994

Data zakończenia 31 Sierpnia 1995

Finansowanie w ramach

• International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993-

Koszt całkowity € 0,00

Wkład UE € 24 000,00

Koordynowany przez

Universitat Autònoma de Barcelona
Spain

Exploitable results

Development of thermodynamically defined solid contact for polymer ion selective membranes and application of screen-printing technology for fabrication of miniature all-solid-state potentiometric sen

A new photocurable poylmer matrix based on polyurethane has been developed which may be regarded as an appropriate alternative to PVC for ion selective membranes formation. Ion selective electrodes (ISE) and ion-sensitive field effect transistors (ISFETs) with photocurable polymer membrane sensitive to potassium, ammonium, and calcium ions have been studied. Composition of the membranes was optimized, the optimization parameters being the type of cross-linker, the type and amount of plasticiser, the amount of the photoinitiator. The sensors waere characterized in terms of their sensitivity, selectivity, stability, limit of detection and life-time during constant contact with the solution. Analytical parameters of the sensors with the optimized membrane composition are comparable to those of PVC. Though the selectivity coefficients of the polyurethane membrane are higher than those of PVC-base ISE they have reasonable values for practical application of these sensors. Low interference from lipophilic anions and long life-time during constant contact with solution are characteristic for the membranes studied. The studied photocurable polymer matrix was used to construct ISEs with solid inner contact. The sensors were produced in macro-electrode as well as in planar configuration utilizing photolithography and screen printing techniques. Additional intermediate contact layer based on electron-ion-exchange resin that provide thermodynamocal reversibility at the membrane/solid contact interface is developed. Analytical parameters of solid-state ion sensors with thermodynamically defined solid contact are studied. The designed sensors were applied for potassium ion concentration measurements in the whole blood, plasma and dialysis solution control within working artificial kidney.