The cytotoxic proteins responsible for cancer cell death

Projektinformationen

ID Finanzhilfevereinbarung: INTAS-93-2411

Projekt abgeschlossen

Startdatum 1 Juni 1995

Enddatum 31 Mai 1996

Finanziert unter

• International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993-

Gesamtkosten

Keine Daten

EU-Beitrag

€ 50 000,00

Koordiniert durch

International Centre for Genetic Engineering and Biotechnology
Italy

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Verwertbare Ergebnisse

The cytotoxic proteins responsible for cancer cell death

The project lead to a number of findings that may give important insights into the mechanism of cell death. In particular, monoclonal antibodies to the novel LAK cells proteins were obtained. These antibodies are used to screen cDNA expression libraries prepared from LAK cells RNA. The antibodies obtained possessed the immunocrossreactivity to the LAK cells proteins and the novel cytotoxic proteins TAG7. The affinity-sorbent with high specificity to LAK cells proteins was prepared. The human TAG7 was found in activated lymphocytes. It was found that both TNF and LAK cells proteins induced apoptotic death in non-metastatic tumour cell lines and did not effect the metastatic tumour cell lines.