The cytotoxic proteins responsible for cancer cell death

Informazioni relative al progetto

ID dell’accordo di sovvenzione: INTAS-93-2411

Progetto chiuso

Data di avvio 1 Giugno 1995

Data di completamento 31 Maggio 1996

Finanziato da

• International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993-

Costo totale

Nessun dato

Contributo UE

€ 50 000,00

Coordinato da

International Centre for Genetic Engineering and Biotechnology
Italy

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati sfruttabili

The cytotoxic proteins responsible for cancer cell death

The project lead to a number of findings that may give important insights into the mechanism of cell death. In particular, monoclonal antibodies to the novel LAK cells proteins were obtained. These antibodies are used to screen cDNA expression libraries prepared from LAK cells RNA. The antibodies obtained possessed the immunocrossreactivity to the LAK cells proteins and the novel cytotoxic proteins TAG7. The affinity-sorbent with high specificity to LAK cells proteins was prepared. The human TAG7 was found in activated lymphocytes. It was found that both TNF and LAK cells proteins induced apoptotic death in non-metastatic tumour cell lines and did not effect the metastatic tumour cell lines.