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Development of ultrasensitive methods for proteome: application to cystic fibrosis (EUROPROCF)

Ziel

The objective of this proposal is to characterise differentially displayed (dd) proteins and mRNAs whose expression patterns are specific to cystic fibrosis (CF) in order to get a better understanding of the mechanisms underlying this disease, and to improve diagnosis and/or therapy. CF is the most common lethal monogenic disease in Europe. It is recognised that CFTR, the key protein whose dysfunction causes CF, is at the crossroad of important pathways and plays major roles, most of them unknown, within a network of proteins central to a whole series of cellular functions. As a result, not only genetic predisposition but also many environmental and/or pharmacological factors can affect CF severity. So far, the reponses of CF to these various factors have been studied in a limited context such as, for instance, one gene or pathway at a time. Thus studies of proteomics of CF are needed. We will use high performance techniques to analyse the protein patterns from cells of CF patients vs. non-affected individuals and will establish a database of dd-proteins and mRNAs. Our new techniques for proteome analysis will be useful for other applications.

Aufforderung zur Vorschlagseinreichung

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Koordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Adresse
Faculté De Médecine Necker - Enfants Malades, Rue
75730 Paris
Frankreich

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Beteiligte (7)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Frankreich
Adresse
Hôpital Henri Mondor, Avenue Du Maréchal De Lattre
94010 Creteil

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INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS - POLISH ACADEMY OF SCIENCES
Polen
Adresse
36,pawinskiego 5a
02-106 Warszawa

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INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS - POLISH ACADEMY OF SCIENCES
Polen
Adresse
Pawinskiego 5a
02-106 Warszawa

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NATIONAL RESEARCH INSTITUTE FOR MOTHER AND CHILD
Polen
Adresse
Kasprazaka, 17 A
01-211 Warsaw

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PROTEOSYS AG
Deutschland
Adresse
Kupferberterrasse 17-19
55116 Mainz

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UNIVERSITY COLLEGE LONDON
United Kingdom
Adresse
University Street 5
WC1E 6JJ London

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UNIVERSITY OF COPENHAGEN
Dänemark
Adresse
Blegdamsvej 3c, Bld.6.2.
2200 Koepenhagen

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