Cel The goals of MEMTRANS project are to optimize and pre-validate in vitro cultured cell models to predict oral absorption and pharmacokinetics of efflux systems substrates (P-gp, MRP2, BCRX for instance), to establish an in vitro cut off for the risk of secretion associated problems and to study the structure-affinity-transport relationships. That would allow:1) A reduction in the number of animal experiments to study efflux processes;2) The in vitro study of drug-drug (including phytopharmaca), drug-food, interactions related with secretion transporters;3) To obtain useful information for modelling transporter interactions in other normal and transformed tissues (blood brain barrier, lung mucosa, tumours).The objectives of the project will be achieved by using a systems biology approach that involves modelling and simulating the complex dynamic interactions between proteins (transporters), metabolites (i.e substrates) and cells (lipoidal barriers). Computational and mathematical predictive models will be generated from the data based on the system parameters and in the drug characteristics. The experimental data generated in the project will be analysed from a mechanistical point of view in order to split all the individual steps involved in transport. The mathematical models in combination with the right physiological, physicochemical and chemical information could be applied to predict drug transport in a wide range of membranes in the organism (blood brain barrier, liver, kidney, tumours etc.) but especially in the gastrointestinal tract. Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepharmacology and pharmacypharmacokineticsnatural sciencesmathematicsapplied mathematicsmathematical model Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LSH-2004-1.2.3-2 - Optimization and pre-validation of in-vitro models for the study of drug absorption, modification and detoxification in the liver and in the intestinal epithelium (especially orientated towards involve Zaproszenie do składania wniosków FP6-2004-LIFESCIHEALTH-5 Zobacz inne projekty w ramach tego zaproszenia System finansowania IP - Integrated Project Koordynator UNIVERSITAT DE VALÈNCIA. ESTUDI GENERAL Wkład UE Brak danych Adres AVDA. BLASCO IBAÑEZ, 13 22085 VALENCIA Hiszpania Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (6) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko INTERVALENCE BIOKINETICS S.L. Hiszpania Wkład UE Brak danych Adres Benjamin Franklin 12. PATERNA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych ACROSS BARRIERS GMBH Niemcy Wkład UE Brak danych Adres Stuhlsatzenhausweg 69 SAARBRÜCKEN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych SOLVO BIOTECHNOLOGY INC. Węgry Wkład UE Brak danych Adres Béke u. 5/A SZEGED Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych AUKSTIEJI ALGORITMAI Litwa Wkład UE Brak danych Adres Mickeviciaus 29 VILNIUS Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych NATIONAL MEDICAL CENTER Węgry Wkład UE Brak danych Adres Szabolcs u. 35. BUDAPEST Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych INSTITUTE OF ENZIMOLOGY, BIOLOGICAL RESEARCH CENTER, HUNGARIAN ACADEMY OF SCIENCES Węgry Wkład UE Brak danych Adres Karolina ut 29 BUDAPEST Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
