Cel The use of hemopoietic growth factors for irradiation therapy have been investigated. Although a relationship between the early GM-CSF response and the dose of irradiation could be established, the variability of response and slow response time made use of GM-CSF impractical. However, GM-CSF was totally effective against leukopenia after a radiation dose of 5 Gy total body irradiation (about 2-log stem cell depletion), but it became increasingly less effective at higher doses of irradiation. Studies with the much more broadly acting growth factor IL-3, were also carried out. Molecular cloning and production of rhesus monkey IL-3 was successfully achieved and preclinical pilot studies, using unirradiated monkeys, have been completed. The positive selection of hemopoietic stem cells was also achieved, by developing a large-scale method based on selection of CD34+ cells. These preparations have been successfully tested in autologous transplantation experiments. Dziedzina nauki medical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicinetransplantation Program(-y) FP1-RADPROT 6C - Multiannual research and training programme (Euratom) in the field of radiation protection, 1985-1989 Temat(-y) Data not available Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator TNO RADIOBIOLOGICAL INSTITUTE Wkład UE Brak danych Adres DIVISION FOR HEALTH RESEARCH LANGE KLEIWEG 151 2280 HV RIJSWIJK Niderlandy Zobacz na mapie Koszt całkowity Brak danych
