Cel The progress in liquid chromatography (LC), basically following Moore’s law over the last decade, will soon come to a halt. LC is the current state-of-the-art chemical separation method to measure the composition of complex mixtures. Driven by the ever growing complexity of the samples in e.g. environmental and biomedical research, LC is constantly pushed to higher efficiencies. Using highly optimized and monodisperse spherical particles, randomly packed in high pressure columns, the progress in LC has up till now been realized by reducing the particle size and concomitantly increasing the pressure. With pressure already up at 1500 bar, groundbreaking progress is still badly needed, e.g. to fully unravel the complex reaction networks in human cells.For this purpose, it is proposed to leave the randomly packed bed paradigm and move to structures wherein the 1 to 5 micrometer particles currently used in LC are arranged in perfectly ordered and open-structured geometries. This is now possible, as the latest advances in nano-manufacturing and positioning allow proposing and developing an inventive high-throughput particle assembly and deposition strategy. The PI's ability to develop new parts of chromatography will be used to rationally optimize the many possible geometries accessible through this disruptive new technology, and identify those structures coping best with any remaining degree of disorder. Using the PI's experimental know-how on microfluidic chromatography systems, these structures will be used to pursue the disruptive gain margin (order of factor 100 in separation speed) that is expected based on general chromatography theory. Testing this groundbreaking new generation of LC columns together with world-leading bio-analytical scientists will illustrate their potential in making new discoveries in biology and life sciences. The new nano-assembly strategies might also be pushed to other applications, such as photonic crystals. Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesphysical sciencesclassical mechanicsfluid mechanicsfluid dynamicscomputational fluid dynamicsnatural sciencesmathematicspure mathematicsgeometrysocial scienceslaw Słowa kluczowe Separation science Liquid chromatography Microfluidics Lab-on-a-chip Ordered hierarchical materials Program(-y) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Temat(-y) ERC-ADG-2015 - ERC Advanced Grant Zaproszenie do składania wniosków ERC-2015-AdG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-ADG - Advanced Grant Instytucja przyjmująca VRIJE UNIVERSITEIT BRUSSEL Wkład UE netto € 2 488 812,50 Adres PLEINLAAN 2 1050 Bruxelles / Brussel Belgia Zobacz na mapie Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 2 488 812,50 Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko VRIJE UNIVERSITEIT BRUSSEL Belgia Wkład UE netto € 2 488 812,50 Adres PLEINLAAN 2 1050 Bruxelles / Brussel Zobacz na mapie Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 2 488 812,50