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Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine

Deliverables

Data availability and knowledge discovery tool to monitor for the availability of the different data types

Data availability and knowledge discovery tool to monitor for the availability of the different data types

Development of guidelines for reporting biomarker results and their classification into different levels of evidence

Development of guidelines for reporting biomarker results and their classification into different levels of evidence

Searching for OpenAIRE data...

Publications

7 T imaging reveals a gradient in spinal cord lesion distribution in multiple sclerosis

Author(s): Russell Ouellette, Constantina A Treaba, Tobias Granberg, Elena Herranz, Valeria Barletta, Ambica Mehndiratta, Benjamin De Leener, Shahamat Tauhid, Fawad Yousuf, Sarah M Dupont, Eric C Klawiter, Jacob A Sloane, Rohit Bakshi, Julien Cohen-Adad, Caterina Mainero
Published in: Brain, 143/10, 2020, Page(s) 2973-2987, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awaa249

Longitudinal DNA methylation changes at MET may alter HGF/c-MET signalling in adolescents at risk for depression

Author(s): Diana M. Ciuculete, Sarah Voisin, Lara Kular, Nipuni Welihinda, Jörgen Jonsson, Maja Jagodic, Jessica Mwinyi, Helgi B. Schiöth
Published in: Epigenetics, 15/6-7, 2020, Page(s) 646-663, ISSN 1559-2294
Publisher: Landes Bioscience
DOI: 10.1080/15592294.2019.1700628

MRI‐Based Manual versus Automated Corpus Callosum Volumetric Measurements in Multiple Sclerosis

Author(s): Michael Platten, Juha Martola, Katharina Fink, Russell Ouellette, Fredrik Piehl, Tobias Granberg
Published in: Journal of Neuroimaging, 30/2, 2020, Page(s) 198-204, ISSN 1051-2284
Publisher: Sage Science Press
DOI: 10.1111/jon.12676

Smoking and Epstein–Barr virus infection in multiple sclerosis development

Author(s): Anna Karin Hedström, Jesse Huang, Nicole Brenner, Julia Butt, Jan Hillert, Tim Waterboer, Ingrid Kockum, Tomas Olsson, Lars Alfredsson
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-67883-w

Inflammation-related plasma and CSF biomarkers for multiple sclerosis

Author(s): Jesse Huang, Mohsen Khademi, Lars Fugger, Örjan Lindhe, Lenka Novakova, Markus Axelsson, Clas Malmeström, Clara Constantinescu, Jan Lycke, Fredrik Piehl, Tomas Olsson, Ingrid Kockum
Published in: Proceedings of the National Academy of Sciences, 117/23, 2020, Page(s) 12952-12960, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1912839117

Finding cell-specific expression patterns in the early Ciona embryo with single-cell RNA-seq

Author(s): Garth R. Ilsley, Ritsuko Suyama, Takeshi Noda, Nori Satoh, Nicholas M. Luscombe
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-61591-1

Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA (Mhc2ta)

Author(s): Sonja Hochmeister, Shahin Aeinehband, Charles Dorris, Rasmus Berglund, Michaela T. Haindl, Vid Velikic, Sven A. Gustafsson, Tomas Olsson, Fredrik Piehl, Maja Jagodic, Manuel Zeitelhofer, Milena Z. Adzemovic
Published in: Frontiers in Neurology, 11, 2020, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.600401

A pharmacogenetic study implicates NINJ2 in the response to Interferon-β in multiple sclerosis

Author(s): Silvia Peroni, Melissa Sorosina, Sunny Malhotra, Ferdinando Clarelli, Ana Maria Osiceanu, Laura Ferrè, Tina Roostaei, Jordi Rio, Luciana Midaglia, Luisa María Villar, José Carlos Álvarez-Cermeño, Clara Guaschino, Marta Radaelli, Lorena Citterio, Jeannette Lechner-Scott, Nino Spataro, Arcadi Navarro, Vittorio Martinelli, Xavier Montalban, Howard L Weiner, Philip de Jager, Giancarlo Comi, Feder
Published in: Multiple Sclerosis Journal, 26/9, 2020, Page(s) 1074-1082, ISSN 1352-4585
Publisher: SAGE Publications
DOI: 10.1177/1352458519851428

Nervous System Involvement in Coronavirus Disease 2019: Results from a Retrospective Consecutive Neuroimaging Cohort

Author(s): Stefanos Klironomos, Antonios Tzortzakakis, Annika Kits, Claes Öhberg, Evangelia Kollia, Amir Ahoromazdae, Håkan Almqvist, Åsa Aspelin, Heather Martin, Russell Ouellette, Jonathan Al-Saadi, Mikael Hasselberg, Mansour Haghgou, Mitra Pedersen, Sven Petersson, Johannes Finnsson, Johan Lundberg, Anna Falk Delgado, Tobias Granberg
Published in: Radiology, 297/3, 2020, Page(s) E324-E334, ISSN 0033-8419
Publisher: Radiological Society of North America
DOI: 10.1148/radiol.2020202791

Transcript-specific regulation in T-cells in multiple sclerosis susceptibility

Author(s): Lies Van Horebeek, An Goris
Published in: European Journal of Human Genetics, 28/7, 2020, Page(s) 849-850, ISSN 1018-4813
Publisher: Natue Publishing Group
DOI: 10.1038/s41431-020-0615-y

Smoking and multiple sclerosis risk: a Mendelian randomization study

Author(s): Marijne Vandebergh, An Goris
Published in: Journal of Neurology, 267/10, 2020, Page(s) 3083-3091, ISSN 0340-5354
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-020-09980-4

Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology

Author(s): Zheleznyakova GY, Piket E, Needhamsen M, Hagemann-Jensen M, Ekman D, Han Y, James T, Khademi M, Al Nimer F, Scicluna P, Huang J, Kockum I, Faridani OR, Olsson T, Piehl F, Jagodic M
Published in: Proc Natl Acad Sci U S A. 2021 Apr 27;118(17), 2021, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2011574118

Genetic determinants of the humoral immune response in MS

Author(s): Christiane Gasperi, Till F.M. Andlauer, Ana Keating, Benjamin Knier, Ana Klein, Verena Pernpeintner, Peter Lichtner, Ralf Gold, Frauke Zipp, Florian Then Bergh, Martin Stangel, Hayrettin Tumani, Brigitte Wildemann, Heinz Wiendl, Antonios Bayas, Tania Kümpfel, Uwe K. Zettl, Ralf A. Linker, Ulf Ziemann, Matthias Knop, Clemens Warnke, Manuel A. Friese, Friedemann Paul, Björn Tackenberg, Achim Berth
Published in: Neurology - Neuroimmunology Neuroinflammation, 7/5, 2020, Page(s) e827, ISSN 2332-7812
Publisher: Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
DOI: 10.1212/nxi.0000000000000827

Quantitative MRI phenotypes capture biological heterogeneity in multiple sclerosis patients

Author(s): Ide Smets, An Goris, Marijne Vandebergh, Jelle Demeestere, Stefan Sunaert, Patrick Dupont, Bénédicte Dubois
Published in: Scientific Reports, 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-81035-8

Rituximab treatment for multiple sclerosis

Author(s): Benjamin V Ineichen, Thomas Moridi, Tobias Granberg, Fredrik Piehl
Published in: Multiple Sclerosis Journal, 26/2, 2020, Page(s) 137-152, ISSN 1352-4585
Publisher: SAGE Publications
DOI: 10.1177/1352458519858604

Impact of multiple sclerosis risk loci in postinfectious neurological syndromes

Author(s): Filippo Martinelli-Boneschi, Riccardo Currò, Silvia Santoro, Giulia Berzero, Melissa Sorosina, Laura Ferrè, Elisabetta Mascia, Silvia Peroni, Giancarlo Comi, Angelo Gugliemi, Elisa Vegezzi, Ilaria Callegari, Massimo Filippi, Andrea Cortese, Federica Esposito, Ferdinando Clarelli, Enrico Marchioni
Published in: Multiple Sclerosis and Related Disorders, 44, 2020, Page(s) 102326, ISSN 2211-0348
Publisher: Elsevier
DOI: 10.1016/j.msard.2020.102326

Epstein–Barr virus infection after adolescence and human herpesvirus 6A as risk factors for multiple sclerosis

Author(s): M. Biström, D. Jons, E. Engdahl, R. Gustafsson, J. Huang, N. Brenner, J. Butt, L. Alonso‐Magdalena, M. Gunnarsson, M. Vrethem, N. Bender, T. Waterboer, G. Granåsen, T. Olsson, I. Kockum, O. Andersen, A. Fogdell‐Hahn, Peter Sundström
Published in: European Journal of Neurology, 28/2, 2021, Page(s) 579-586, ISSN 1351-5101
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ene.14597

Cytomegalovirus seropositivity is associated with reduced risk of multiple sclerosis - a presymptomatic case-control study.

Author(s): Grut V, Biström M, Salzer J, Stridh P, Jons D, Gustafsson R, Fogdell-Hahn A, Huang J, Brenner N, Butt J, Bender N, Lindam A, Alonso-Magdalena L, Gunnarsson M, Vrethem M, Bergström T, Andersen O, Kockum I, Waterboer T, Olsson T, Sundström P
Published in: Eur J Neurol., 2021, ISSN 1351-5101
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ene.14961

Epigenetic insights into multiple sclerosis disease progression

Author(s): L. Kular, M. Jagodic
Published in: Journal of Internal Medicine, 288/1, 2020, Page(s) 82-102, ISSN 0954-6820
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/joim.13045

Deep characterization of paired chromatin and transcriptomes in four immune cell types from multiple sclerosis patients. . 2021 Oct;13(20):1607-1618. doi: /

Author(s): Fernandes SJ, Ericsson M, Khademi M, Jagodic M, Olsson T, Gomez-Cabrero D, Kockum I, Tegnér J.
Published in: Epigenomics, 2021, ISSN 1750-1911
Publisher: Future Medicine Ltd.
DOI: 10.2217/epi-2021-0205

Neurological manifestations of coronavirus infections – a systematic review

Author(s): Jesper Almqvist, Tobias Granberg, Antonios Tzortzakakis, Stefanos Klironomos, Evangelia Kollia, Claes Öhberg, Roland Martin, Fredrik Piehl, Russell Ouellette, Benjamin V. Ineichen
Published in: Annals of Clinical and Translational Neurology, 7/10, 2020, Page(s) 2057-2071, ISSN 2328-9503
Publisher: Wiley Periodicals LLC on behalf of American Neurological Association.
DOI: 10.1002/acn3.51166

GeneSetCluster: a tool for summarizing and integrating gene-set analysis results

Author(s): Ewoud Ewing, Nuria Planell-Picola, Maja Jagodic, David Gomez-Cabrero
Published in: BMC Bioinformatics, 21/1, 2020, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-020-03784-z

DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis

Author(s): Lara Kular, Yun Liu, Sabrina Ruhrmann, Galina Zheleznyakova, Francesco Marabita, David Gomez-Cabrero, Tojo James, Ewoud Ewing, Magdalena Lindén, Bartosz Górnikiewicz, Shahin Aeinehband, Pernilla Stridh, Jenny Link, Till F. M. Andlauer, Christiane Gasperi, Heinz Wiendl, Frauke Zipp, Ralf Gold, Björn Tackenberg, Frank Weber, Bernhard Hemmer, Konstantin Strauch, Stefanie Heilmann-Heimbach, Rajesh
Published in: Nature Communications, 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-04732-5

Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity

Author(s): Simone Ecker, Vera Pancaldi, Alfonso Valencia, Stephan Beck, Dirk S. Paul
Published in: BioEssays, 40/2, 2018, Page(s) 1700148, ISSN 0265-9247
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/bies.201700148

Impact of genetic risk loci for multiple sclerosis on expression of proximal genes in patients

Author(s): Tojo James, Magdalena Lindén, Hiromasa Morikawa, Sunjay Jude Fernandes, Sabrina Ruhrmann, Mikael Huss, Maya Brandi, Fredrik Piehl, Maja Jagodic, Jesper Tegnér, Mohsen Khademi, Tomas Olsson, David Gomez-Cabrero, Ingrid Kockum
Published in: Human Molecular Genetics, 27/5, 2018, Page(s) 912-928, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddy001

Epigenetic variation taking center stage in immunological research

Author(s): Simone Ecker, Stephan Beck
Published in: Epigenomics, 9/4, 2017, Page(s) 375-378, ISSN 1750-1911
Publisher: Future Medicine Ltd.
DOI: 10.2217/epi-2017-0006

Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod

Author(s): Fredrik Piehl, Ingrid Kockum, Mohsen Khademi, Kaj Blennow, Jan Lycke, Henrik Zetterberg, Tomas Olsson
Published in: Multiple Sclerosis Journal, 24/8, 2018, Page(s) 1046-1054, ISSN 1352-4585
Publisher: SAGE Publications
DOI: 10.1177/1352458517715132

Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations

Author(s): Sigurgeir Olafsson, Pernilla Stridh, Steffan Daniël Bos, Andres Ingason, Jack Euesden, Patrick Sulem, Gudmar Thorleifsson, Omar Gustafsson, Ari Johannesson, Arni J. Geirsson, Arni V. Thorsson, Bardur Sigurgeirsson, Bjorn Runar Ludviksson, Elias Olafsson, Helga Kristjansdottir, Jon G. Jonasson, Jon Hjaltalin Olafsson, Kjartan B. Orvar, Rafn Benediktsson, Ragnar Bjarnason, Sjofn Kristjansdottir, Th
Published in: npj Genomic Medicine, 2/1, 2017, ISSN 2056-7944
Publisher: NPJ Genom Med
DOI: 10.1038/s41525-017-0027-2

Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis

Author(s): Patricia Lechner, Dorothea Buck, Lisa Sick, Bernhard Hemmer, Gabriele Multhoff
Published in: Multiple Sclerosis Journal - Experimental, Translational and Clinical, 4/2, 2018, Page(s) 205521731876719, ISSN 2055-2173
Publisher: Mult Scler J Exp Transl Clin.
DOI: 10.1177/2055217318767192

The origins of diversity in human immunity

Author(s): Adrian Liston, An Goris
Published in: Nature Immunology, 19/3, 2018, Page(s) 209-210, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-018-0047-9

Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells

Author(s): Ide Smets, Barnaby Fiddes, Josselyn E Garcia-Perez, Di He, Klara Mallants, Wenjia Liao, James Dooley, George Wang, Stephanie Humblet-Baron, Bénédicte Dubois, Alastair Compston, Joanne Jones, Alasdair Coles, Adrian Liston, Maria Ban, An Goris, Stephen Sawcer
Published in: Brain, 141/3, 2018, Page(s) 786-796, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awx372

Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins

Author(s): Amy P. Webster, Darren Plant, Simone Ecker, Flore Zufferey, Jordana T. Bell, Andrew Feber, Dirk S. Paul, Stephan Beck, Anne Barton, Frances M. K. Williams, Jane Worthington
Published in: Genome Medicine, 10/1, 2018, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-018-0575-9

Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship

Author(s): Francesco Marabita, Malin Almgren, Louise K. Sjöholm, Lara Kular, Yun Liu, Tojo James, Nimrod B. Kiss, Andrew P. Feinberg, Tomas Olsson, Ingrid Kockum, Lars Alfredsson, Tomas J. Ekström, Maja Jagodic
Published in: Scientific Reports, 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-14788-w

Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes

Author(s): Sabrina Ruhrmann, Ewoud Ewing, Eliane Piket, Lara Kular, Julio Cesar Cetrulo Lorenzi, Sunjay Jude Fernandes, Hiromasa Morikawa, Shahin Aeinehband, Sergi Sayols-Baixeras, Stella Aslibekyan, Devin M Absher, Donna K Arnett, Jesper Tegner, David Gomez-Cabrero, Fredrik Piehl, Maja Jagodic
Published in: Multiple Sclerosis Journal, 24/10, 2018, Page(s) 1288-1300, ISSN 1352-4585
Publisher: SAGE Publications
DOI: 10.1177/1352458517721356

Ensembl 2018

Author(s): Daniel R Zerbino, Premanand Achuthan, Wasiu Akanni, M Ridwan Amode, Daniel Barrell, Jyothish Bhai, Konstantinos Billis, Carla Cummins, Astrid Gall, Carlos García Girón, Laurent Gil, Leo Gordon, Leanne Haggerty, Erin Haskell, Thibaut Hourlier, Osagie G Izuogu, Sophie H Janacek, Thomas Juettemann, Jimmy Kiang To, Matthew R Laird, Ilias Lavidas, Zhicheng Liu, Jane E Loveland, Thomas Maurel, Willia
Published in: Nucleic Acids Research, 46/D1, 2017, Page(s) D754-D761, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkx1098

Association of Intrathecal Immunoglobulin G Synthesis With Disability Worsening in Multiple Sclerosis

Author(s): Christiane Gasperi, Anke Salmen, Gisela Antony, Antonios Bayas, Christoph Heesen, Tania Kümpfel, Ralf A. Linker, Friedemann Paul, Martin Stangel, Björn Tackenberg, Florian Then Bergh, Clemens Warnke, Frank Weber, Heinz Wiendl, Brigitte Wildemann, Uwe K. Zettl, Ulf Ziemann, Frauke Zipp, Hayrettin Tumani, Ralf Gold, Bernhard Hemmer
Published in: JAMA Neurology, 76/7, 2019, Page(s) 841, ISSN 2168-6149
Publisher: American Medical Association
DOI: 10.1001/jamaneurol.2019.0905

Towards a European health research and innovation cloud (HRIC)

Author(s): F. M. Aarestrup, A. Albeyatti, W. J. Armitage, C. Auffray, L. Augello, R. Balling, N. Benhabiles, G. Bertolini, J. G. Bjaalie, M. Black, N. Blomberg, P. Bogaert, M. Bubak, B. Claerhout, L. Clarke, B. De Meulder, G. D’Errico, A. Di Meglio, N. Forgo, C. Gans-Combe, A. E. Gray, I. Gut, A. Gyllenberg, G. Hemmrich-Stanisak, L. Hjorth, Y. Ioannidis, S. Jarmalaite, A. Kel, F. Kherif, J. O. Korbel, C. L
Published in: Genome Medicine, 12/1, 2020, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-020-0713-z

CHIT1 at Diagnosis Reflects Long‐Term Multiple Sclerosis Disease Activity

Author(s): Emanuela Oldoni, Ide Smets, Klara Mallants, Marijne Vandebergh, Lies Van Horebeek, Koen Poesen, Patrick Dupont, Bénédicte Dubois, An Goris
Published in: Annals of Neurology, 2020, ISSN 0364-5134
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ana.25691

A Systematic Assessment of Prevalence, Incidence and Regional Distribution of Multiple Sclerosis in Bavaria From 2006 to 2015

Author(s): Tanja Daltrozzo, Alexander Hapfelmeier, Ewan Donnachie, Antonius Schneider, Bernhard Hemmer
Published in: Frontiers in Neurology, 9, 2018, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2018.00871

CSF parameters associated with early MRI activity in patients with MS

Author(s): Ana Klein, Rebecca C. Selter, Alexander Hapfelmeier, Achim Berthele, Bertram Müller-Myhsok, Viola Pongratz, Christiane Gasperi, Claus Zimmer, Mark Mühlau, Bernhard Hemmer
Published in: Neurology - Neuroimmunology Neuroinflammation, 6/4, 2019, Page(s) e573, ISSN 2332-7812
Publisher: A. Neurol Neuroimmunol Neuroinflamm.
DOI: 10.1212/nxi.0000000000000573

Increased Serological Response Against Human Herpesvirus 6A Is Associated With Risk for Multiple Sclerosis

Author(s): Elin Engdahl, Rasmus Gustafsson, Jesse Huang, Martin Biström, Izaura Lima Bomfim, Pernilla Stridh, Mohsen Khademi, Nicole Brenner, Julia Butt, Angelika Michel, Daniel Jons, Maria Hortlund, Lucia Alonso-Magdalena, Anna Karin Hedström, Louis Flamand, Masaru Ihira, Tetsushi Yoshikawa, Oluf Andersen, Jan Hillert, Lars Alfredsson, Tim Waterboer, Peter Sundström, Tomas Olsson, Ingrid Kockum, Anna Fog
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Front immunol
DOI: 10.3389/fimmu.2019.02715

LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients

Author(s): Chiara Fenoglio, Emanuela Oldoni, Maria Serpente, Milena A. De Riz, Marina Arcaro, Marianna D'Anca, Anna M. Pietroboni, Alberto Calvi, Elisabetta Lecchi, An Goris, Klara Mallants, Bénédicte Dubois, Cristoforo Comi, Roberto Cantello, Elio Scarpini, Daniela Galimberti
Published in: Journal of Neuroimmunology, 324, 2018, Page(s) 129-135, ISSN 0165-5728
Publisher: Elsevier BV
DOI: 10.1016/j.jneuroim.2018.08.008

The influence of human leukocyte antigen-DRB1*15:01 and its interaction with smoking in MS development is dependent on DQA1*01:01 status

Author(s): Anna Karin Hedström, Ola Hössjer, Jan Hillert, Pernilla Stridh, Ingrid Kockum, Tomas Olsson, Lars Alfredsson
Published in: Multiple Sclerosis Journal, 2019, Page(s) 135245851987768, ISSN 1352-4585
Publisher: SAGE Publications
DOI: 10.1177/1352458519877685

Low sun exposure increases multiple sclerosis risk both directly and indirectly

Author(s): Anna Karin Hedström, Tomas Olsson, Ingrid Kockum, Jan Hillert, Lars Alfredsson
Published in: Journal of Neurology, 2019, ISSN 0340-5354
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-019-09677-3

A large case-control study on vaccination as risk factor for multiple sclerosis

Author(s): Alexander Hapfelmeier, Christiane Gasperi, Ewan Donnachie, Bernhard Hemmer
Published in: Neurology, 93/9, 2019, Page(s) e908-e916, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000008012

Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators

Author(s): Vasiliki Lagou, Josselyn E. Garcia-Perez, Ide Smets, Lies Van Horebeek, Marijne Vandebergh, Liye Chen, Klara Mallants, Teresa Prezzemolo, Kelly Hilven, Stephanie Humblet-Baron, Matthieu Moisse, Philip Van Damme, Guy Boeckxstaens, Paul Bowness, Bénédicte Dubois, James Dooley, Adrian Liston, An Goris
Published in: Cell Reports, 25/3, 2018, Page(s) 798-810.e6, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.09.048

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Author(s): Sven J. van der Lee, Olivia J. Conway, Iris Jansen, Minerva M. Carrasquillo, Luca Kleineidam, Erik van den Akker, Isabel Hernández, Kristel R. van Eijk, Najada Stringa, Jason A. Chen, Anna Zettergren, Till F. M. Andlauer, Monica Diez-Fairen, Javier Simon-Sanchez, Alberto Lleó, Henrik Zetterberg, Marianne Nygaard, Cornelis Blauwendraat, Jeanne E. Savage, Jonas Mengel-From, Sonia Moreno-Grau, Mich
Published in: Acta Neuropathologica, 138/2, 2019, Page(s) 237-250, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-019-02026-8

Non-parametric combination analysis of multiple data types enables detection of novel regulatory mechanisms in T cells of multiple sclerosis patients

Author(s): Sunjay Jude Fernandes, Hiromasa Morikawa, Ewoud Ewing, Sabrina Ruhrmann, Rubin Narayan Joshi, Vincenzo Lagani, Nestoras Karathanasis, Mohsen Khademi, Nuria Planell, Angelika Schmidt, Ioannis Tsamardinos, Tomas Olsson, Fredrik Piehl, Ingrid Kockum, Maja Jagodic, Jesper Tegnér, David Gomez-Cabrero
Published in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-48493-7

Leveraging human genetics to inform intervention strategies for multiple sclerosis

Author(s): An Goris, Bénédicte Dubois
Published in: Neurology, 92/16, 2019, Page(s) 735-736, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000007298

Validation of rapid magnetic resonance myelin imaging in multiple sclerosis

Author(s): Russell Ouellette, Gabriel Mangeat, Ildiko Polyak, Marcel Warntjes, Yngve Forslin, åsa Bergendal, Michael Plattén, Martin Uppman, Constantina Andrada Treaba, Julien Cohen‐Adad, Fredrik Piehl, Maria Kristoffersen Wiberg, Sten Fredrikson, Caterina Mainero, Tobias Granberg
Published in: Annals of Neurology, 2020, ISSN 0364-5134
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ana.25705

DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning

Author(s): Janine Arloth, Gökcen Eraslan, Till F. M. Andlauer, Jade Martins, Stella Iurato, Brigitte Kühnel, Melanie Waldenberger, Josef Frank, Ralf Gold, Bernhard Hemmer, Felix Luessi, Sandra Nischwitz, Friedemann Paul, Heinz Wiendl, Christian Gieger, Stefanie Heilmann-Heimbach, Tim Kacprowski, Matthias Laudes, Thomas Meitinger, Annette Peters, Rajesh Rawal, Konstantin Strauch, Susanne Lucae, Bertram Mül
Published in: PLOS Computational Biology, 16/2, 2020, Page(s) e1007616, ISSN 1553-7358
Publisher: PLoS Comput Biol
DOI: 10.1371/journal.pcbi.1007616

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

Author(s): Mitja Mitrovič, Nikolaos A. Patsopoulos, Ashley H. Beecham, Theresa Dankowski, An Goris, Bénédicte Dubois, Marie B. D’hooghe, Robin Lemmens, Philip Van Damme, Helle Bach Søndergaard, Finn Sellebjerg, Per Soelberg Sorensen, Henrik Ullum, Lise W. Thørner, Thomas Werge, Janna Saarela, Isabelle Cournu-Rebeix, Vincent Damotte, Bertrand Fontaine, Lena Guillot-Noel, Mark Lathrop, Sandra Vukusik, P
Published in: Cell, 175/6, 2018, Page(s) 1679-1687.e7, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.09.049

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Author(s): Patsopoulos, N.A., Baranzini, S.E., Santaniello, A., Shoostari, P., Cotsapas, C., Wong, G., Beecham, A.H., James, T., Replogle, J., Vlachos, I.S., McCabe, C., Pers, T.H., Brandes, A., White, C., Keenan, B., Cimpean, M., Winn, P., Panteliadis, I-P., Robbins, A., Andlauer, T.F M., Zarzycki, O., Dubois, B., Goris, A., Sondergaard, H.B., Sellebjerg, F., Sorensen, P.S., Ullum, H., Thorner, L.W., Saarel
Published in: Science, 365/6460, 2019, Page(s) eaav7188, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aav7188

Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk

Author(s): Katarina Tengvall, Jesse Huang, Cecilia Hellström, Patrick Kammer, Martin Biström, Burcu Ayoglu, Izaura Lima Bomfim, Pernilla Stridh, Julia Butt, Nicole Brenner, Angelika Michel, Karin Lundberg, Leonid Padyukov, Ingrid E. Lundberg, Elisabet Svenungsson, Ingemar Ernberg, Sigurgeir Olafsson, Alexander T. Dilthey, Jan Hillert, Lars Alfredsson, Peter Sundström, Peter Nilsson, Tim Waterboer, Tomas O
Published in: Proceedings of the National Academy of Sciences, 116/34, 2019, Page(s) 16955-16960, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1902623116

Prognostic value of white matter lesion shrinking in early multiple sclerosis: An intuitive or naïve notion?

Author(s): Viola Pongratz, Paul Schmidt, Matthias Bussas, Sophia Grahl, Christian Gaser, Achim Berthele, Muna‐Miriam Hoshi, Jan Kirschke, Claus Zimmer, Bernhard Hemmer, Mark Mühlau
Published in: Brain and Behavior, 9/12, 2019, ISSN 2162-3279
Publisher: Brain Behav
DOI: 10.1002/brb3.1417

Confounding effect of blood volume and body mass index on blood neurofilament light chain levels

Author(s): Ali Manouchehrinia, Fredrik Piehl, Jan Hillert, Jens Kuhle, Lars Alfredsson, Tomas Olsson, Ingrid Kockum
Published in: Annals of Clinical and Translational Neurology, 7/1, 2019, Page(s) 139-143, ISSN 2328-9503
Publisher: Ann Clin Transl Neurol.
DOI: 10.1002/acn3.50972

A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease

Author(s): Lies Van Horebeek, Kelly Hilven, Klara Mallants, Annemarie Van Nieuwenhuijze, Tiina Kelkka, Paula Savola, Satu Mustjoki, Susan M Schlenner, Adrian Liston, Bénédicte Dubois, An Goris
Published in: Human Molecular Genetics, 28/8, 2018, Page(s) 1369-1380, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddy425

Somatic Variants: New Kids on the Block in Human Immunogenetics

Author(s): L. Van Horebeek, B. Dubois, A. Goris
Published in: Trends in Genetics, 35/12, 2019, Page(s) 935-947, ISSN 0168-9525
Publisher: Elsevier BV
DOI: 10.1016/j.tig.2019.09.005

Cytokine and immune cell profiling in the cerebrospinal fluid of patients with neuro-inflammatory diseases

Author(s): Gildas Lepennetier, Zsuzsanna Hracsko, Marina Unger, Martijn Van Griensven, Verena Grummel, Markus Krumbholz, Achim Berthele, Bernhard Hemmer, Markus C. Kowarik
Published in: Journal of Neuroinflammation, 16/1, 2019, ISSN 1742-2094
Publisher: BioMed Central
DOI: 10.1186/s12974-019-1601-6

Blood neurofilament light levels segregate treatment effects in multiple sclerosis

Author(s): Bénédicte Delcoigne, Ali Manouchehrinia, Christian Barro, Pascal Benkert, Zuzanna Michalak, Ludwig Kappos, David Leppert, Jon A. Tsai, Tatiana Plavina, Bernd C. Kieseier, Jan Lycke, Lars Alfredsson, Ingrid Kockum, Jens Kuhle, Tomas Olsson, Fredrik Piehl
Published in: Neurology, 2020, Page(s) 10.1212/WNL.0000000000009097, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000009097

A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis

Author(s): Madireddy, L., Patsopoulos, N.A., Cotsapas, C., Bos, S.D., Beecham, A., McCauley, J., Kim, K., Jia, X., Santaniello, A., Caillier, S.J., Andlauer, T.F M., Barcellos, L.F., Berge, T., Bernardinelli, L., Martinelli-Boneschi, F., Booth, D.R., Briggs, F., Celius, E.G., Comabella, M., Comi, G., Cree, B.A C., D'Alfonso, S., Dedham, K., Duquette, P., Efthimios, D., Esposito, F., Fontaine, B., Gasperi, C.
Published in: Nature Communications, 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09773-y

Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis

Author(s): Karl E. Carlström, Keying Zhu, Ewoud Ewing, Inge E. Krabbendam, Robert A. Harris, Ana Mendanha Falcão, Maja Jagodic, Gonçalo Castelo-Branco, Fredrik Piehl
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17871-5

C-type lectin receptors Mcl and Mincle control development of multiple sclerosis–like neuroinflammation

Author(s): Marie N’diaye, Susanna Brauner, Sevasti Flytzani, Lara Kular, Andreas Warnecke, Milena Z. Adzemovic, Eliane Piket, Jin-Hong Min, Will Edwards, Filia Mela, Hoi Ying Choi, Vera Magg, Tojo James, Magdalena Linden, Holger M. Reichardt, Michael R. Daws, Jack van Horssen, Ingrid Kockum, Robert A. Harris, Tomas Olsson, Andre O. Guerreiro-Cacais, Maja Jagodic
Published in: Journal of Clinical Investigation, 130/2, 2019, Page(s) 838-852, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci125857

Pregnancy does not modify the risk of MS in genetically susceptible women

Author(s): Cameron J. Adams, Sean L. Wu, Xiaorong Shao, Patrick T. Bradshaw, Edlin Gonzales, Jessica B. Smith, Anny H. Xiang, Kalliope H. Bellesis, Terrence Chinn, Steffan D. Bos, Marte Wendel-Haga, Tomas Olsson, Ingrid Kockum, Annette M. Langer-Gould, Catherine Schaefer, Lars Alfredsson, Lisa F. Barcellos
Published in: Neurology - Neuroimmunology Neuroinflammation, 7/6, 2020, Page(s) e898, ISSN 2332-7812
Publisher: Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
DOI: 10.1212/nxi.0000000000000898

Methylome and transcriptome signature of bronchoalveolar cells from multiple sclerosis patients in relation to smoking

Author(s): Mikael V Ringh, Michael Hagemann-Jensen, Maria Needhamsen, Susanna Kullberg, Jan Wahlström, Johan Grunewald, Boel Brynedal, Maja Jagodic, Tomas J Ekström, Johan Öckinger, Lara Kular
Published in: Multiple Sclerosis Journal, 2020, Page(s) 135245852094376, ISSN 1352-4585
Publisher: SAGE Publications
DOI: 10.1177/1352458520943768

Multiple sclerosis lesions in motor tracts from brain to cervical cord: spatial distribution and correlation with disability

Author(s): Anne Kerbrat, Charley Gros, Atef Badji, Elise Bannier, Francesca Galassi, Benoit Combès, Raphaël Chouteau, Pierre Labauge, Xavier Ayrignac, Clarisse Carra-Dalliere, Josefina Maranzano, Tobias Granberg, Russell Ouellette, Leszek Stawiarz, Jan Hillert, Jason Talbott, Yasuhiko Tachibana, Masaaki Hori, Kouhei Kamiya, Lydia Chougar, Jennifer Lefeuvre, Daniel S Reich, Govind Nair, Paola Valsasina, Mar
Published in: Brain, 143/7, 2020, Page(s) 2089-2105, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awaa162

Enlarged perivascular spaces in multiple sclerosis on magnetic resonance imaging: a systematic review and meta-analysis

Author(s): Tobias Granberg, Thomas Moridi, Judith S. Brand, Susanne Neumann, Martin Hlavica, Fredrik Piehl, Benjamin V. Ineichen
Published in: Journal of Neurology, 267/11, 2020, Page(s) 3199-3212, ISSN 0340-5354
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-020-09971-5

Ensembl 2021

Author(s): Kevin L Howe, Premanand Achuthan, James Allen, Jamie Allen, Jorge Alvarez-Jarreta, M Ridwan Amode, Irina M Armean, Andrey G Azov, Ruth Bennett, Jyothish Bhai, Konstantinos Billis, Sanjay Boddu, Mehrnaz Charkhchi, Carla Cummins, Luca Da Rin Fioretto, Claire Davidson, Kamalkumar Dodiya, Bilal El Houdaigui, Reham Fatima, Astrid Gall, Carlos Garcia Giron, Tiago Grego, Cristina Guijarro-Clarke, Lea
Published in: Nucleic Acids Research, 49/D1, 2020, Page(s) D884-D891, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa942

Machine Learning and Multiparametric Brain MRI to Differentiate Hereditary Diffuse Leukodystrophy with Spheroids from Multiple Sclerosis

Author(s): Gabriel Mangeat, Russell Ouellette, Maxime Wabartha, Benjamin De Leener, Michael Plattén, Virginija Danylaité Karrenbauer, Marcel Warntjes, Nikola Stikov, Caterina Mainero, Julien Cohen‐Adad, Tobias Granberg
Published in: Journal of Neuroimaging, 30/5, 2020, Page(s) 674-682, ISSN 1051-2284
Publisher: Sage Science Press
DOI: 10.1111/jon.12725