Cel The plant immune system is innate – it is encoded in the germline. In natural pathosystems, plants efficiently deploy hundreds of immune receptors to detect and disarm rapidly evolving pathogens including viruses, bacteria, nematodes, insects, fungi and oomycetes. Exactly how such receptor diversity can evolve is an elusive question with important practical ramifications. A central class of plant immune receptors, called Nucleotide Binding Leucine Rich Repeats proteins (NLR), has been implicated in recognition of vastly diverse pathogen-derived effector molecules. An emerging paradigm of receptor diversification in plant genomes involves new gene fusions of receptors with host proteins that are normally targeted by pathogen effectors. Such fusion receptors ‘bait’ pathogens and their integrated domains are thought to function as ‘decoys’ or ‘sensors’ that mediate pathogen recognition. I have recently demonstrated that the mechanism of generating new receptors through gene fusions originated at least 500 million years ago in mosses and is common to all flowering plants. Here, I propose to decode the mechanisms of plant immune receptor diversification by gene fusions by studying diversity and functions of immune receptors in grasses, a young highly diversified plant family that includes the three most important crops: maize, rice and wheat. My specific aims are to: 1) Determine rates of receptor diversification within and across genomes 2) Dissect the mechanisms of receptor regulation and receptor activation 3) Generate novel plant immune receptors based on the NLR platform prone to fusions. In this MIREDI research programme, I will combine state of the art sequencing techniques and bioinformatics, molecular biology and novel reverse genetics techniques to study how plant immune system co-evolves with pathogens and what limits diversification of immunity in domesticated crops. Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological scienceszoologyentomologynatural sciencesbiological sciencesgeneticsnucleotidesnatural sciencesbiological sciencesgeneticsgenomesnatural sciencesbiological sciencesmolecular biology Słowa kluczowe Plant disease resistance immune receptors pathogens pathogen effectors Program(-y) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Temat(-y) ERC-2016-STG - ERC Starting Grant Zaproszenie do składania wniosków ERC-2016-STG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-STG - Starting Grant Instytucja przyjmująca EARLHAM INSTITUTE Wkład UE netto € 882 899,00 Adres NORWICH RESEARCH PARK COLNEY LANE NR4 7UZ Norwich Zjednoczone Królestwo Zobacz na mapie Region East of England East Anglia Breckland and South Norfolk Rodzaj działalności Research Organisations Linki Kontakt z organizacją Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 882 899,00 Beneficjenci (2) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko EARLHAM INSTITUTE Zjednoczone Królestwo Wkład UE netto € 882 899,00 Adres NORWICH RESEARCH PARK COLNEY LANE NR4 7UZ Norwich Zobacz na mapie Region East of England East Anglia Breckland and South Norfolk Rodzaj działalności Research Organisations Linki Kontakt z organizacją Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 882 899,00 THE SAINSBURY LABORATORY Zjednoczone Królestwo Wkład UE netto € 617 098,00 Adres Norwich Research Park, Colney Lane NR47UH Norwich Zobacz na mapie Region East of England East Anglia Norwich and East Norfolk Rodzaj działalności Research Organisations Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 617 098,00