Cel This research project aims to address one of the Grand Challenges in contemporary science: the de-novo synthesis of life. More specifically we aim to achieve, for the first time, (i) development of replicators that feature a primitive photometabolism, and (ii) Darwinian evolution of such fully synthetic molecules. These ambitious aims are firmly grounded on the unique expertise of the host lab (self-replicating molecules) combined with the strong expertise of the ER (self-assembly and photochemistry). This combination will enable the adaptive integration of a photoactive co-factor (e.g. a porphyrin) with replicator fibers which will activate photocatalytic production of singlet oxygen. This singlet oxygen promotes the oxidation of thiol building blocks into “food” (i.e. small disulfide macrocycles) which the replicator can utilize to make copies of itself. In the final phase of the project we will operate the photometabolic self-replicating system under far-from-equilibrium conditions in an open flow system in which replication competes with physical removal (“death”). This regime should allow for Darwinian evolution, provided that replicator mutation is facilitated by providing different building blocks. In order to survive, replicators need to replicate faster than they are being destroyed. Therefore, selection should favour the replicator with the highest catalytic efficiency. Overall, the designed systems will exhibit all aspects of Darwinian evolution: replication, mutation and selection. While evolution in biology requires long periods of time, herein we aim, for the first time, to realize evolution in a fully synthetic system within a short timeframe, and obtain photometabolic replicators with activities that have been improved through Darwinian evolution. Dziedzina nauki engineering and technologymaterials engineeringfibersnatural scienceschemical scienceselectrochemistryelectrolysisnatural scienceschemical sciencesphysical chemistryphotochemistrynatural sciencesbiological sciencesgeneticsmutation Program(-y) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Temat(-y) MSCA-IF-2017 - Individual Fellowships Zaproszenie do składania wniosków H2020-MSCA-IF-2017 Zobacz inne projekty w ramach tego zaproszenia System finansowania MSCA-IF-EF-ST - Standard EF Koordynator RIJKSUNIVERSITEIT GRONINGEN Wkład UE netto € 165 598,80 Adres Broerstraat 5 9712CP Groningen Niderlandy Zobacz na mapie Region Noord-Nederland Groningen Overig Groningen Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 165 598,80