In-silico Development- and Clinical-Trial-Platform for Testing in-situ Tissue Engineered Heart Valves

Projektinformationen

SimInSitu

ID Finanzhilfevereinbarung: 101017523

DOI

10.3030/101017523

EK-Unterschriftsdatum 3 Dezember 2020

Startdatum 1 Januar 2021

Enddatum 31 Dezember 2025

Finanziert unter

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Gesamtkosten

€ 5 410 692,50

EU-Beitrag

€ 5 410 692,50

Koordiniert durch

4REALSIM SERVICES BV
Netherlands

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (23)

EU Periodic Report 1

obligatory periodic project status reporting to EUfollowing the end of each reporting period the functionality of periodic reporting will be activated While the periodic reporting session is open in the grant management system each participant will be able tocomplete online their own Financial Statement and the financial report of their Third Parties if any including the explanations on the use of resources upload the narrative free text part part B of the periodic technical report as a pdf document

Scaffold Material Model ABAQUS Validation Report

Validation report describing the conducted validation tests for the developed Abaqus UMAT/VUMAT code / material model

Scaffold Material Model ABAQUS Verification Report

Verification report describing the conducted code verification tests for the developed Abaqus UMATVUMAT code

Patient-specific Xeltis-PV validation & UQ report

Model validation & UQ by comparing computed data with available clinical data sets.

Benchmark TAVI FSI-model - VVUQ report

Verification/Validation & UQ report for the Benchmark TAVI FSI-model. This report covers the FSI model.

EU Periodic Report 2

obligatory periodic project status reporting to EUfollowing the end of each reporting period the functionality of periodic reporting will be activated. While the periodic reporting session is open in the grant management system, each participant will be able to:complete on-line their own Financial Statement (and the financial report of their Third Parties, if any) including the explanations on the use of resources; upload the narrative, free text part (part B) of the periodic technical report as a pdf document

Dissemination Plan Update
Patient-specific Xeltis-PV calibration & verification report

Patient-specific calibration & verification simulations performed on 15 data sets. Comparison with available clinical data will be used to fine-tune the models.

Xeltis-PV FE-model - VVUQ report

Verification/Validation & UQ report for the Xeltis-PV FE-model. This report covers only the structural part of the model. FSI is not part of this report

Scaffold Material Test Data & Test Report Ia

Final test report about polymer scaffold material characterization program as conducted by Leartiker

Stent Material Evaluation and Calibration Report

Test report on the material evaluation and calibration of Nitinol as used for TVAI systems

Data Management Plan

Data Management Plans DMPs are a key element of good data management A DMP describes the data management life cycle for the data to be collected processed andor generated by a Horizon 2020 project As part of making research data findable accessible interoperable and reusable FAIR a DMP should include information on the handling of research data during after the end of the project what data will be collected processed andor generated which methodology standards will be applied whether data will be sharedmade open access and how data will be curated preserved including after the end of the projectA DMP is required for all projects participating in the extended ORD pilot unless they opt out of the ORD pilot However projects that opt out are still encouraged to submit a DMP on a voluntary basis

Scaffold Material Test Data & Test Report Id

Final test report about polymer scaffold material characterization program as conducted by TUGraz

Dissemination Plan
Patient specific Benchmark-TAVI validation & UQ report

UQ & validation report based on 100 patient-specific simulations (previously prepared models). Comparison with clinical data sets.

Exploitation Plan
Scaffold Material Fatigue Test Report

Final report on the fatigue behavior of the polymeric scaffold material considering the need to provide fatigue stability until it is fully remodeled.

Scaffold Material Test UQ Report

Test report on UQ of test results coming from Scaffold Material Test Data & Report 1a / 1b / 1c / 1d.

Scaffold Material Test Data & Test Report Ib

Final test report about polymer scaffold material characterization program as conducted by KULeuven Soft Tissue Biomechancs

Patient specific Benchmark-TAVI calibration & verification report

Patient-specific calibration & verification simulations performed on 20 patient data sets.Comparison of pre-TAVI & post-TAVI scenarios with available clinical data will be used to fine-tune the models.

Benchmark TAVI FE-model - VVUQ report

Verification/Validation & UQ report for the Benchmark TAVI FE-model. This report covers only the structural part of the model. FSI is not part of this report

Project Management Plan

Project Management Plan: classic project management document that covers all relevant items, such as in-scope / out-of-scope, time management, resource management, risk management, communication management etc. Items overlapping with Grant Agreement, Consortium Agreement, and Data Management will be referenced.

Scaffold Material Test Data & Test Report Ic

Final test report about polymer scaffold material characterization program as conducted by Armines MINES Sainttienne Soft Tissue Biomechanics

Websites, patent fillings, videos etc. (1)

SimInSitu Media Data set

Webpage project brochure online presence flyer

Data sets, microdata, etc (1)

Patient specific AV imaging data sets (130)

Patient Data from Procurement, Digitisation, and Curation (ISMETT)Morphological and Physiological Data Collection and Classification

Open Research Data Pilot (1)

patient-specific Benchmark TAVI Repository

developed & validated patient specific Benchmark TAVI model will be provided to public

Other (1)

ETR Constitutive Equations

developed constitutive equations (material model) to describe the ETR process of the biodegradable polymeric scaffold material. Builds upon material model developed in WP1 & WP2

Veröffentlichungen

Other (4)

Abstract: Novel bioresorbable carotid graft: experimental assessment through an animal model.

Autoren: Hendrickx Amber
Veröffentlicht in: 2022
Herausgeber: European Society of biomechanics

ABSTRACT: PARAMETER SENSITIVITY AND OPTIMIZATION OF THE MECHANO IMMUNO-DRIVEN MODEL OF ENDOGENOUS TISSUE RESTORATION.

Autoren: Hadi Shirazi et al.
Veröffentlicht in: 2023
Herausgeber: European Society of BIomechanics

ABSTRACT: NOVEL BIORESORBABLE PULMONARY VALVES: EXPERIMENTAL ASSESSMENT THROUGH AN ANIMAL TRIAL.

Autoren: Hendrickx Amber
Veröffentlicht in: 2023
Herausgeber: European Society of Biomechanics

Computational Modeling of Endogenous Tissue Restoration in Biodegradable Carotid Grafts

Autoren: H. Shirazi, L. Maes, T. Vervenne, N. Famaey
Veröffentlicht in: 2024
Herausgeber: ESB2024 congress

Thesis and dissertations (1)

Computational Predictive Modeling of a Novel Pulmonary Valved Conduit

Autoren: van Tunen, Rick
Veröffentlicht in: 2023
Herausgeber: TU Delft

Peer reviewed articles (7)

On the Material Constitutive Behavior of the Aortic Root in Patients with Transcatheter Aortic Valve Implantation

Autoren: Chiara Catalano, Tahir Turgut, Omar Zahalka, Nils Götzen, Stefano Cannata, Giovanni Gentile, Valentina Agnese, Caterina Gandolfo & Salvatore Pasta
Veröffentlicht in: Cardiovasc Eng Tech, 2023, ISSN 1869-4098
Herausgeber: Cardiovasc Eng Tech
DOI: 10.1007/s13239-023-00699-7

Generation of a virtual cohort of TAVI patients for in silico trials: a statistical shape and machine learning analysis

Autoren: Roberta Scuoppo, Salvatore Castelbuono, Stefano Cannata, Giovanni Gentile, Valentina Agnese, Diego Bellavia, Caterina Gandolfo, Salvatore Pasta
Veröffentlicht in: Medical & Biological Engineering & Computing, Ausgabe 63, 2025, Seite(n) 467-482, ISSN 0140-0118
Herausgeber: Institute of Electrical Engineers
DOI: 10.1007/s11517-024-03215-8

Modelling the anisotropic inelastic response of polymeric scaffolds for in situ tissue engineering applications

Autoren: Michele Terzano, Maximilian P. Wollner, Manuel P. Kainz, Malte Rolf-Pissarczyk, Nils Götzen and Gerhard A. Holzapfel
Veröffentlicht in: Journal of the royal society interface, 2023, ISSN 1742-5662
Herausgeber: Royal Society
DOI: 10.1098/rsif.2023.0318

A reparameterization-invariant Bayesian framework for uncertainty estimation and calibration of simple materials

Autoren: Maximilian P. Wollner, Malte Rolf-Pissarczyk, Gerhard A. Holzapfel
Veröffentlicht in: Computational Mechanics, 2025, ISSN 0178-7675
Herausgeber: Springer Verlag
DOI: 10.1007/s00466-024-02573-2

Re-interpretation of the Homogenized Constrained Mixture Theory within the plasticity framework and application to soft tissue growth and remodeling

Autoren: Felipe Sempértegui, Stéphane Avril
Veröffentlicht in: Computer Methods in Applied Mechanics and Engineering, Ausgabe 412, 2023, Seite(n) 116059, ISSN 0045-7825
Herausgeber: Elsevier BV
DOI: 10.1016/j.cma.2023.116059

On the accuracy of the segmentation process and transcatheter heart valve dimensions in TAVI patients

Autoren: Roberta Scuoppo, Stefano Cannata, Caterina Gandolfo, Diego Bellavia, Salvatore Pasta
Veröffentlicht in: Journal of Biomechanics, Ausgabe 176, 2024, Seite(n) 112357, ISSN 0021-9290
Herausgeber: Elsevier BV
DOI: 10.1016/j.jbiomech.2024.112357

A general model for anisotropic pseudo-elasticity and viscoelasticity at finite strains

Autoren: Maximilian P. Wollner a, Michele Terzano a, Malte Rolf-Pissarczyk a, Gerhard A. Holzapfel a b
Veröffentlicht in: Journal of the Mechanics and Physics of Solids, 2023, ISSN 0022-5096
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.jmps.2023.105403