In-silico Development- and Clinical-Trial-Platform for Testing in-situ Tissue Engineered Heart Valves

Informazioni relative al progetto

SimInSitu

ID dell’accordo di sovvenzione: 101017523

DOI 10.3030/101017523

Data della firma CE 3 Dicembre 2020

Data di avvio 1 Gennaio 2021

Data di completamento 31 Dicembre 2024

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale € 5 410 692,50

Contributo UE € 5 410 692,50

Coordinato da

4REALSIM SERVICES BV
Netherlands

Risultati finali

Documents, reports (13)

EU Periodic Report 1

obligatory periodic project status reporting to EUfollowing the end of each reporting period the functionality of periodic reporting will be activated While the periodic reporting session is open in the grant management system each participant will be able tocomplete online their own Financial Statement and the financial report of their Third Parties if any including the explanations on the use of resources upload the narrative free text part part B of the periodic technical report as a pdf document

Scaffold Material Model ABAQUS Validation Report

Validation report describing the conducted validation tests for the developed Abaqus UMAT/VUMAT code / material model

Scaffold Material Model ABAQUS Verification Report

Verification report describing the conducted code verification tests for the developed Abaqus UMATVUMAT code

Dissemination Plan Update
Xeltis-PV FE-model - VVUQ report

Verification/Validation & UQ report for the Xeltis-PV FE-model. This report covers only the structural part of the model. FSI is not part of this report

Scaffold Material Test Data & Test Report Ia

Final test report about polymer scaffold material characterization program as conducted by Leartiker

Stent Material Evaluation and Calibration Report

Test report on the material evaluation and calibration of Nitinol as used for TVAI systems

Data Management Plan

Data Management Plans DMPs are a key element of good data management A DMP describes the data management life cycle for the data to be collected processed andor generated by a Horizon 2020 project As part of making research data findable accessible interoperable and reusable FAIR a DMP should include information on the handling of research data during after the end of the project what data will be collected processed andor generated which methodology standards will be applied whether data will be sharedmade open access and how data will be curated preserved including after the end of the projectA DMP is required for all projects participating in the extended ORD pilot unless they opt out of the ORD pilot However projects that opt out are still encouraged to submit a DMP on a voluntary basis

Scaffold Material Test Data & Test Report Id

Final test report about polymer scaffold material characterization program as conducted by TUGraz

Dissemination Plan
Scaffold Material Test Data & Test Report Ib

Final test report about polymer scaffold material characterization program as conducted by KULeuven Soft Tissue Biomechancs

Patient specific Benchmark-TAVI calibration & verification report

Patient-specific calibration & verification simulations performed on 20 patient data sets.Comparison of pre-TAVI & post-TAVI scenarios with available clinical data will be used to fine-tune the models.

Scaffold Material Test Data & Test Report Ic

Final test report about polymer scaffold material characterization program as conducted by Armines MINES Sainttienne Soft Tissue Biomechanics

Websites, patent fillings, videos etc. (1)

SimInSitu Media Data set

Webpage project brochure online presence flyer

Other (1)

ETR Constitutive Equations

developed constitutive equations (material model) to describe the ETR process of the biodegradable polymeric scaffold material. Builds upon material model developed in WP1 & WP2

Pubblicazioni

Other (3)

Abstract: Novel bioresorbable carotid graft: experimental assessment through an animal model.

Autori: Hendrickx Amber.
Pubblicato in: 2022
Editore: European Society of biomechanics

ABSTRACT: PARAMETER SENSITIVITY AND OPTIMIZATION OF THE MECHANO IMMUNO-DRIVEN MODEL OF ENDOGENOUS TISSUE RESTORATION.

Autori: Hadi Shirazi et al.
Pubblicato in: 2023
Editore: European Society of BIomechanics

ABSTRACT: NOVEL BIORESORBABLE PULMONARY VALVES: EXPERIMENTAL ASSESSMENT THROUGH AN ANIMAL TRIAL.

Autori: Hendrickx Amber
Pubblicato in: 2023
Editore: European Society of Biomechanics

Thesis and dissertations (1)

Computational Predictive Modeling of a Novel Pulmonary Valved Conduit

Autori: van Tunen, Rick
Pubblicato in: 2023
Editore: TU Delft

Peer reviewed articles (3)

On the Material Constitutive Behavior of the Aortic Root in Patients with Transcatheter Aortic Valve Implantation

Autori: Chiara Catalano, Tahir Turgut, Omar Zahalka, Nils Götzen, Stefano Cannata, Giovanni Gentile, Valentina Agnese, Caterina Gandolfo & Salvatore Pasta
Pubblicato in: Cardiovasc Eng Tech, 2023, ISSN 1869-4098
Editore: Cardiovasc Eng Tech
DOI: 10.1007/s13239-023-00699-7

Modelling the anisotropic inelastic response of polymeric scaffolds for in situ tissue engineering applications

Autori: Michele Terzano, Maximilian P. Wollner, Manuel P. Kainz, Malte Rolf-Pissarczyk, Nils Götzen and Gerhard A. Holzapfel
Pubblicato in: Journal of the royal society interface, 2023, ISSN 1742-5662
Editore: Royal Society
DOI: 10.1098/rsif.2023.0318

A general model for anisotropic pseudo-elasticity and viscoelasticity at finite strains

Autori: Maximilian P. Wollner a, Michele Terzano a, Malte Rolf-Pissarczyk a, Gerhard A. Holzapfel a b
Pubblicato in: Journal of the Mechanics and Physics of Solids, 2023, ISSN 0022-5096
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.jmps.2023.105403