Altogether this two-year fellowship led to the discovery that myelin (even in its non-compact form) does contribute to inhibitory precision within the hippocampus. We provided evidence that by driving inhibitory precision, myelin supports locally generated networks. This shows that, in contrary to the existing general belief, myelin around short and thin axons can provide a speed advantage to locally projecting PV+ BC interneurons. Our study is unique in the sense that it managed to link subcellular observations (axonal myelination) to synaptic function and how this has implications on the behavior of populations of neurons that form microcircuits. Our description of the dependency of inhibitory latencies on the presence of myelin provides novel parameters required to build realistic in silico models. Our data moreover offer preliminary cues to a potential mechanism that might explain memory deficits in MS patients.
As a training grant, this MSCA fellowship allowed me to learn novel techniques (holographic optogenetics, Local Field Potential measurements, Ca2+-imaging) and related analysis methods. It contributed to the broadening of my interests (into structural- and glia cell biology), provided me with mentoring and supervision skills, boosted my managerial capabilities, and created unique networking opportunities that could be of invaluable importance for my future career. In return I was able to transfer my specific knowledge about hippocampal physiology and skills in synaptic electrophysiology to the host lab. Preliminary scientific results have been presented and discussed at conferences and workshops, a manuscript including the findings of both objectives of this fellowship is in its final stages of preparation.
