In our pursuit of quantum entanglement between interacting particles, we have designed and built a new experimental setup featuring Heisenberg-limited detection efficiency with independent control and motion readout for both optically trapped particles. We also developed an original quantum Langevin model to define the parameter space for the entanglement problem in both the steady state and the dynamical regime. By combining both active and passive particle charging methodologies, we achieved the experimental parameter space required for entanglement generation. We managed to trap mesoporous particles with a surface area two orders of magnitude larger and a few times less mass, resulting in almost an order of magnitude higher coupling strength. Our split homodyne interferometry achieves an impressive 50% total detection efficiency of motion, representing a significant advancement toward ground state cooling and entanglement generation. Furthermore, optimal protocols that we developed is a promising avenue for ground state preparation and entanglement generation. Expected future outcomes include realization of these protocols followed by experimental validation of the entanglement. Morevoer the project contributes to the field of cavity-controlled chemistry, nonlinear, and quantum optics with molecules, promising macroscopic quantum coherent phenomena immune against decoherence and disorder at room temperature. The socio-economic impact is substantial, as these innovations promote fundamental research, could drive technological advancements, foster international collaborations, and enhance educational initiatives in related fields.