The MSCA “Polymeric Membranes for Artificial Endosymbionts (PolyMAE)” investigates a cutting-edge technique for encapsulating prokaryotes in biocompatible shells, aimed at the production of bio-orthogonal artificial endosymbionts. Endosymbionts are organisms that thrive within a host organism, usually in a symbiotic relationship. Notably, mitochondria and plastids such as chloroplasts in eukaryotic cells are considered to be endosymbionts of bacterial origin. Through mimicking nature's wisdom, synthetic biology is at the forefront in modifying the molecular biology of the host to incorporate other organisms, with the ultimate goal of developing entire genetic circuits and metabolic pathways.
Central to the PolyMAE project is the concept of artificial endosymbiosis. Encasing the 'guest' organisms in biocompatible polymers bolsters the prospects of achieving artificial endosymbiosis. The use of polymeric membranes ensures that the encapsulated organisms are protected and can effectively integrate with the host's biology.
Such advancements have far-reaching implications, particularly in the fields of medicine and biotechnology. For instance, the ability to produce artificial endosymbionts can revolutionize drug delivery systems, wherein encapsulated microorganisms can be engineered to deliver therapeutic agents directly to targeted cells.
Furthermore, in agriculture and environmental sciences, these artificial endosymbionts could be used to promote plant growth or mitigate environmental pollutants, through the establishment of beneficial relationships between the artificial endosymbionts and plant cells.
This research also fosters an interdisciplinary approach. It contributes to a broader understanding of the delicate interactions between different biological entities and how they can be harnessed for societal good. In summary, the PolyMAE project, funded by the Marie Skłodowska-Curie Actions programme, marks a substantial stride in the realm of synthetic biology. By exploring novel techniques for encapsulating prokaryotes within biocompatible polymeric membranes, it opens avenues for the production of artificial endosymbionts with potential applications in medicine, biotechnology, agriculture, and environmental sciences. This project is not just about scientific innovation but also represents an epitome of how principles of design and creative thinking can result in solutions that address global challenges and contribute positively to society.
