Archaeal Virology: unravelling the mechanisms of interviral warfare

Informacje na temat projektu

ARCVIR

Identyfikator umowy o grant: 101039446

DOI

10.3030/101039446

Data podpisania przez KE 15 Lutego 2022

Data rozpoczęcia 1 Września 2022

Data zakończenia 31 Sierpnia 2027

Finansowanie w ramach

• European Research Council (ERC)

Koszt całkowity

€ 1 500 000,00

Wkład UE

€ 1 500 000,00

Koordynowany przez

RIJKSUNIVERSITEIT GRONINGEN
Netherlands

Periodic Reporting for period 1 - ARCVIR (Archaeal Virology: unravelling the mechanisms of interviral warfare)

Okres sprawozdawczy: 2022-09-01 do 2025-02-28

Podsumowanie kontekstu i ogólnych celów projektu

Archaea are ubiquitous microorganisms that are found in numerous surroundings ranging from extreme environments to the ocean and the human gut and skin. Marine archaea have a huge impact on biogeochemical cycles and the climate, while archaea in the gut influence the human microbiome and health. Archaea can be infected by unusual viruses that are structurally very diverse and have unique infection mechanisms. As viruses are the major predator of archaea, they shape archaeal communities. This project will visualize the mechanisms that viruses use to fight each other to gain access to host cells. This knowledge of viral mechanisms can, for example, be applied to control archaeal populations to increase human gut health or to reduce the production of the harmful greenhouse gas methane by gut archaea of ruminants.

For more information: check www.quaxlab.org

Prace wykonane od początku projektu do końca okresu sprawozdawczego oraz najważniejsze dotychczasowe rezultaty

Viruses from different families were analyzed for their capacity to exclude infection by other viruses, a process called superinfection exclusion. We identified several viruses that serve as model for further studies into the mechanism of superinfection exclusion.

Innowacyjność oraz oczekiwany potencjalny wpływ (w tym dotychczasowe znaczenie społeczno-gospodarcze i szersze implikacje społeczne projektu)

Insight into the molecular mechanism of superinfection exclusion in archaea is currently scarce. These results are the stepping stone for further study of these mechanisms in archaea. This is important to fully understand the role of viruses in natural ecosystems, where viral presence is high.