Targeting Epilepsy Ictogenesis Process Through Pannexin-1 Modulation

Informacje na temat projektu

PanThera

Identyfikator umowy o grant: 101069281

DOI

10.3030/101069281

Projekt został zamknięty

Data podpisania przez KE 31 Maja 2022

Data rozpoczęcia 1 Października 2022

Data zakończenia 31 Marca 2024

Finansowanie w ramach

• European Research Council (ERC)

Koszt całkowity

Brak danych

Wkład UE

€ 150 000,00

Koordynowany przez

COLLEGE DE FRANCE
France

Periodic Reporting for period 1 - PanThera (Targeting Epilepsy Ictogenesis Process Through Pannexin-1 Modulation)

Okres sprawozdawczy: 2022-10-01 do 2024-03-31

Podsumowanie kontekstu i ogólnych celów projektu

Epilepsy, affecting about 1% of the population, comprises a group of neurological disorders characterized by the periodic occurrence of seizures, which disrupt normal brain function. Despite treatment with current antiepileptic drugs, one third of epileptic patients are pharmacoresistant and most patients suffer from side effects, making it crucial to develop novel therapies. Current drugs indeed target channels and receptors involved in normal brain function, not specific to the disease.
Our academic work has recently identified a novel and innovative target for epilepsy, which is active during the transition to epileptic seizures. This target could therefore allow to specifically counteract epileptic seizures without altering physiological cerebral processes. Our preclinical investigations have shown that a molecule acting on this target can counteract seizures both ex vivo in human postoperative epileptic tissues and in vivo in an animal model of recurrent focal epilepsy. These results led to a patent for the use of this molecule to treat epileptic conditions. Our project aimed at completing the pharmacological preclinical package of this molecule as an antiepileptic drug.

Prace wykonane od początku projektu do końca okresu sprawozdawczego oraz najważniejsze dotychczasowe rezultaty

To do so, we characterized its pharmacodynamic-pharmacokinetic activity, tested its dose effect in a model of focal epilepsy, as well as assessed its effect on another form on epilepsy.

Innowacyjność oraz oczekiwany potencjalny wpływ (w tym dotychczasowe znaczenie społeczno-gospodarcze i szersze implikacje społeczne projektu)

This study should contribute to bring to the market a new generation of antiepileptic drugs.