Artificial Intelligence (AI) now powers decision-making in many products and infrastructures—from hospital information system and medical imaging to industrial control systems and web services. This creates a dual challenge: AI can strengthen cyber-defence, yet it also opens new attack paths, including those that cross from the digital world into the physical one. KINAITICS set out to make AI-enabled, cyber-physical systems more robust, resilient, and responsive. The project’s goals were to: (i) unite technical, legal and ethical requirements into practical guidance; (ii) identify and evidence emerging AI-related risks and attack techniques; and (iii) deliver and validate advanced defence frameworks that are usable in realistic settings. The consortium also emphasised trustworthy AI practices (explainability, human-in-the-loop, privacy-by-design) so that organisations can adopt defence tools with confidence and in line with EU rules. KINAITICS concludes with a portfolio of exploitable results (tools, methods, training, and demonstrators), designed for further uptake in research and industry.