Adaptation to climate change in the rhizosphere across the millennia

Informazioni relative al progetto

TOLERATE

ID dell’accordo di sovvenzione: 101082049

DOI

10.3030/101082049

Data della firma CE 4 Dicembre 2023

Data di avvio 1 Dicembre 2023

Data di completamento 30 Novembre 2027

Finanziato da

• Food, Bioeconomy Natural Resources, Agriculture and Environment

Costo totale

€ 3 909 870,00

Contributo UE

€ 3 909 870,00

Coordinato da

DANMARKS TEKNISKE UNIVERSITET
Denmark

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (6)

Initial list of top-candidate genes for genetic engineering and ancestral reconstitution

We will provide an initial list of selected top-candidate genes for engineering to introduce climate tolerance traits into selected microorganisms. The results of attempts at ancestral reconstruction of the origin of traits leading to increased tolerance to drought will also be reported. D1.3 is an outcome of Task 1.2 and it is an input for D1.4.

Initial identification of modern relative microorganisms of those identified in the ancient environmental samples

We will provide an initial report on our comparison of the genomes of archaic drought-adapted taxa with those of modern microorganisms. This can be used to assess adaptation physiological traits and their genetic determinants. D1.5 is an outcome of Task 1.3 and it is an input for D1.6..

Initial lab-scale fermentation and downstream processing development

We will report on the initial results of the optimization of fermentation at lab-scale for production of engineered rhizosphere bacteria. D4.1 is an outcome of Task 4.1 and it is an input for D4.2.

Project management handbook/guidelines

We will provide a report regarding operational and structural details of the consortium as per the requirements of the Grant Agreement regarding financial reporting, presentation standards for deliverables and reports to the European Commission, an internal communication plan and an internal review procedure for quality assurance of project results, etc. D8.4 is an outcome of Task 8.2.

Initial analysis of ancient genomes in environmental samples

We will provide an initial report on target genes selected for genetic engineering as well as microbial taxa and functional genes distinctive for heat/drought conditions. D1.1 is an outcome of Task 1.1 and it is an input for D1.2

Initial plan on communication and dissemination + exploitation

We will provide a report on initial communication and dissemination plans, events and clustering activities. D7.2 is an outcome of Task 7.2 and it is an input for D7.4.

Data Management Plan (1)

First version of the data management plan

We will provide a first report on the data management plan. D8.1 is an outcome of Task 8.1 and it is an input for D8.2.

Websites, patent fillings, videos etc. (1)

Visual identity, website and social media accounts

We will construct a dedicated website. D7.1 is an outcome of Task 7.1.

Pubblicazioni

Peer reviewed articles (8)

Metabolic Origin, Role and Fate of the Denaturant Guanidine

Autori: Antoine Danchin, Victor de Lorenzo, Pablo Iván Nikel, Conghui You
Pubblicato in: Microbial Biotechnology, Numero 18, 2025, ISSN 1751-7915
Editore: Wiley
DOI: 10.1111/1751-7915.70266

A blueprint for designing the next-generation of synthetic C1 microbes

Autori: Giusi Favoino, Òscar Puiggené, Pablo I. Nikel
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-64483-Y

Functional organization and regulatory logic of the <i>ped</i> gene cluster in <i>Pseudomonas</i> species

Autori: Òscar Puiggené, Pablo I. Nikel
Pubblicato in: Applied and Environmental Microbiology, 2026, ISSN 0099-2240
Editore: American Society for Microbiology
DOI: 10.1128/AEM.00046-26

FEMS Microbiology Reviews

Autori: Òscar Puiggené; Giusi Favoino; Filippo Federici; Michele Partipilo; Enrico Orsi; Maria V G Alván-Vargas; Javier M Hernández-Sancho; Nienke K Dekker; Emil C Ørsted; Eray U Bozkurt; Sara Grassi; Ju
Pubblicato in: FEMS Microbiology Reviews, 2025, ISSN 0168-6445
Editore: Blackwell
DOI: 10.1093/FEMSRE/FUAF011

The disputed identity of <i>Pseudomonas putida</i> KT2440: when taxonomists rename your favorite microbe

Autori: Victor de Lorenzo, Danilo Pérez-Pantoja, Juan Luis Ramos, Pablo I. Nikel
Pubblicato in: mBio, 2026, ISSN 2150-7511
Editore: American Society for Microbiology
DOI: 10.1128/MBIO.03390-25

Synthetic C ₁ metabolism in <i>Pseudomonas putida</i> enables strict formatotrophy and methylotrophy via the reductive glycine pathway

Autori: Justine Turlin, Maria V. G. Alván-Vargas, Òscar Puiggené, Stefano Donati, Sebastian Wenk, Pablo I. Nikel
Pubblicato in: mBio, Numero 16, 2025, ISSN 2150-7511
Editore: American Society for Microbiology
DOI: 10.1128/MBIO.01976-25

Precision Proteolysis of Triosephosphate Isomerase of <i>Escherichia coli</i> Boosts Dihydroxyacetone Phosphate Biosynthesis

Autori: Belén Calles, Daniel C. Volke, Max Chavarría, Pablo I. Nikel, Víctor de Lorenzo
Pubblicato in: ACS Synthetic Biology, 2026, ISSN 2161-5063
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACSSYNBIO.5C00870

Growth-coupled microbial biosynthesis of the animal pigment xanthommatin

Autori: Leah B. Bushin, Tobias B. Alter, María V. G. Alván-Vargas, Lara Dürr, Elina C. Olson, Mariah J. Avila, Daniel C. Volke, Òscar Puiggené, Taehwan Kim, Leila F. Deravi, Adam M. Feist, Pablo I. Nikel, Bradley S. Moore
Pubblicato in: Nature Biotechnology, 2025, ISSN 1087-0156
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41587-025-02867-7

Other (1)

FEMS Microbiology Reviews

Autori: Román A. Martino; Daniel C. Volke; Albano H. Tenaglia; Paula M. Tribelli; Pablo I. Nikel; Andrea M. Smania
Pubblicato in: Microbial Biotechnology, 2025
Editore: Blackwell
DOI: 10.1111/1751-7915.70137

Book chapters (1)

Streamlining the Design‐Build‐Test‐Learn Process in Automated Biofoundries

Autori: Enrico Orsi, Nicolás Gurdo, Pablo I. Nikel
Pubblicato in: Machine Learning and Big Data‐enabled Biotechnology, 2026
Editore: Wiley
DOI: 10.1002/9783527850532.CH13