Bridging the gaps in nanosafety for animal-free prediction of adverse outcomes

Projektinformationen

nanoPASS

ID Finanzhilfevereinbarung: 101092741

DOI

10.3030/101092741

EK-Unterschriftsdatum 24 November 2022

Startdatum 1 Januar 2023

Enddatum 31 Dezember 2026

Finanziert unter

• Digital, Industry and Space

Gesamtkosten

€ 3 073 736,25

EU-Beitrag

€ 3 073 736,25

Koordiniert durch

INSTITUT JOZEF STEFAN
Slovenia

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Data sets, microdata, etc (2)

Time-lapse microscopy data

Quantitative data of KE dynamics, extracted from images of time-lapse microscopy over 1–2 days, for 40+ benchmark and 10+ industrial materials on in vitro models for 4 selected adverse outcomes. The data is organised and documented according to FAIR principles, and formatted as needed for modelling in WP3.

List of NM descriptors and early-events - activity indicators

Compilation of selected NM-relevant data obtained with data mining, relating the molecular initiating events (MIEs) and key events (KEs) towards selected adverse outcomes (AOs) with the markers and in vitro/in silico tests.

Websites, patent fillings, videos etc. (3)

Project Communication Plan (PCP)

A document outlining the overall communication strategy (target audiences, key messages, communication tools, schedule) to ensure consistency and the timely release of information about the project

Project website

The one-stop-shop for project communication, both for external audiences and the consortium with a partner-only area. Will provide a repository (news, deliverables, events), and be the first interface for interested stakeholders with a contact form

Plan for Exploitation & Dissemination of Results (PEDR)

A guidance document, reviewed yearly, supporting dissemination activities through a list of desired exploitation outcomes and related success criteria, and a protocol to assess dissemination suitability and related implementation actions.

Documents, reports (3)

Submission of 1 manuscript on an AOP

The manuscript will be based on AOP 237, and it will be submitted to a suitable journal, e.g. ‘Environmental Toxicology and Chemistry’ or ‘Environmental and Molecular Mutagenesis.

Quality Management Plan

The QMP document will detail the roles of partners for the deliverables and milestones, and clear 6-month goals. It will be revised during the course of the project if needed.

ECVAM submission

Report about submission of the proposal for the first animal-free toxicity-prediction method for selected AOs to ECVAM.

Data Management Plan (1)

Management set-up

Set-up of the management structure and decision-making procedures, finalised at the kick-off meeting. Set-up of shared server for exchange of data and files, devised Data Management Plan (DMP) according to FAIR principles.

Other (1)

Predictive QSAR models

Description of physics-based and statistical models to establish quantitative structure-activity and property-activity relationships (QSAR and QSPR, respectively) between the NM descriptors and AO evolution using NM descriptors for selected AOPs.

Veröffentlichungen

Peer reviewed articles (15)

Carbonaceous particle exposure triggered accumulation of Osteopontin/SPP1+ macrophages contributes to emphysema development

Autoren: Han, Lianyong; Haefner, Verena; Yildirim, Ali Önder; Adler, Heiko; Stoeger, Tobias
Veröffentlicht in: MedComm, 2025, ISSN 2688-2663
Herausgeber: Wiley
DOI: 10.1002/MCO2.70061

Acute, controlled inhalation of thin graphene oxide nanosheets in humans with null cardiorespiratory effects.

Autoren: Ulla Vogel
Veröffentlicht in: Nature Nanotechnology, Ausgabe 19, 2024, ISSN 1748-3387
Herausgeber: Springer Nature
DOI: 10.1038/s41565-024-01639-9

Setting off on the right path: make your research regulatory relevant

Autoren: Anna Pohl; Elise Morel; Elise Morel; Eric A. J. Bleeker; Sean Kelly; Rachel Smith; Claus Svendsen; Thomas A. J. Kuhlbusch; Thomas A. J. Kuhlbusch; Thomas A. J. Kuhlbusch; Elisabeth Heunisch
Veröffentlicht in: Frontiers in Research Metrics and Analytics, 2025, ISSN 2504-0537
Herausgeber: Frontiers Media
DOI: 10.3389/FRMA.2025.1561964

Particulate matter constituents trigger the formation of extracellular amyloid β and Tau -containing plaques and neurite shortening in vitro

Autoren: A Sebastijanović, L M Azzurra Camassa, V Malmborg, S Kralj, J Pagels, U Vogel, S Zienolddiny-Narui, I Urbančič, T Koklič and J Štrancar
Veröffentlicht in: Nanotoxicology, 2024, ISSN 1743-5390
Herausgeber: Informa Healthcare
DOI: 10.1080/17435390.2024.2362367

Computational modelling of bionano interface

Autoren: V. Lobaskin, J. Subbotina, I. Rouse
Veröffentlicht in: EPL, Ausgabe 143, 2023, ISSN 1286-4854
Herausgeber: IOP Science
DOI: 10.1209/0295-5075/acf33f

Nanoparticle-Exposure-Triggered Virus Reactivation Induces Lung Emphysema in Mice

Autoren: Han L, Haefner V, Yu Y, Han B, Ren H, Irmler M, Beckers J, Liu Q, Feuchtinger A, Yildirim AO, Adler H, Stoeger T
Veröffentlicht in: ACS Nano, Ausgabe 17/21, 2023, ISSN 1936-086X
Herausgeber: American Chemical Society
DOI: 10.1021/acsnano.3c04111

An elevated rate of whole-genome duplications associated with carcinogen exposure in Black cancer patients

Autoren: Leanne M. Brown; Ryan A. Hagenson; Tilen Koklič; Iztok Urbančič; Janez Strancar; Jason M. Sheltzer
Veröffentlicht in: Crossref, 2023, ISSN 3067-2007
Herausgeber: medRxiv
DOI: 10.1101/2023.11.10.23298349

Detection of Microbial Contamination in Nanomaterials Using LAL, rFC and Cell-Based Assays: Implications for Nanotoxicological Hazard Assessment

Autoren: Peng Lei; Fikirte Debebe Zegeye; Mayes Alswady-Hoff; Chiara Marcolungo; Pernille Høgh Danielsen; Anne Mette Madsen; Håkan Wallin; Ulla Vogel; Shan Zienolddiny-Narui; Johanna Samulin Erdem
Veröffentlicht in: Nanomaterials, 2025, ISSN 2079-4991
Herausgeber: MDPI
DOI: 10.3390/NANO15241871

NPCoronaPredict: A Computational Pipeline for the Prediction of the Nanoparticle–Biomolecule Corona

Autoren: Ian Rouse; David Power; Julia Subbotina; Vladimir Lobaskin
Veröffentlicht in: Journal of Chemical Information and Modeling, 2024, ISSN 1549-960X
Herausgeber: American Chemical Society
DOI: 10.48550/ARXIV.2403.07819

<i>UANanoDock</i>: A Web-Based <i>UnitedAtom</i> Multiscale Nanodocking Tool for Predicting Protein Adsorption onto Nanoparticles

Autoren: Julia Subbotina; Panagiotis D. Kolokathis; Andreas Tsoumanis; Nikolaos K. Sidiropoulos; Ian Rouse; Iseult Lynch; Vladimir Lobaskin; Antreas Afantitis
Veröffentlicht in: Journal of Chemical Information and Modeling, 2025, ISSN 1549-960X
Herausgeber: American Chemical Society
DOI: 10.1021/ACS.JCIM.4C02292

Metadata stewardship in nanosafety research: learning from the past, preparing for an “on-the-fly” FAIR future

Autoren: Thomas E. Exner; Anastasios G. Papadiamantis; Anastasios G. Papadiamantis; Georgia Melagraki; Jaleesia D. Amos; Nathan Bossa; Nathan Bossa; Georgios P. Gakis; Costas A. Charitidis; Geert Cornelis; Anna L. Costa; Philip Doganis; Lucian Farcal; Steffi Friedrichs; Irini Furxhi; Frederick C. Klaessig; Vladimir Lobaskin; Dieter Maier; John Rumble; John Rumble; Haralambos Sarimveis; Blanca Suarez-Merino; Socorro Vázquez; Mark R. Wiesner; Antreas Afantitis; Antreas Afantitis; Iseult Lynch; Iseult Lynch
Veröffentlicht in: Frontiers in Physics, 2023, ISSN 2296-424X
Herausgeber: Frontiers Media
DOI: 10.5281/ZENODO.8326590

Nature Communications

Autoren: Leanne M. Brown; Ryan A. Hagenson; Tilen Koklič; Iztok Urbančič; Lu Qiao; Janez Strancar; Jason M. Sheltzer
Veröffentlicht in: Nature Communications, 2024, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/S41467-024-52554-5

Comparison of Lung Inflammatory and Transcriptional Responses in Mice and Rats Following Pulmonary Exposure to a Fiber Paradigm-Compatible and Non-Compatible MWCNT

Autoren: Laura Aliisa Saarimäki; Pernille Høgh Danielsen; Kristina Bram Knudsen; Sarah Søs Poulsen; Sabina Halappanavar; Henrik Wolff; Pia Anneli Sofia Kinaret; Dario Greco; Ulla Vogel
Veröffentlicht in: Nanomaterials, 2025, ISSN 2079-4991
Herausgeber: MDPI
DOI: 10.3390/NANO15171364

Beilstein Journal of Nanotechnology

Autoren: Parinaz Mosaddeghi Amini; Ian Rouse; Julia Subbotina; Vladimir Lobaskin
Veröffentlicht in: Beilstein Journal of Nanotechnology, 2023, ISSN 2190-4286
Herausgeber: Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
DOI: 10.3762/BJNANO.15.21

The eATP/P2×7R Axis Drives Quantum Dot‐Nanoparticle Induced Neutrophil Recruitment in the Pulmonary Microcirculation

Autoren: Chenxi Li; Qiongliang Liu; Lianyong Han; Haiyun Zhang; Roland Immler; Birgit Rathkolb; Judith Secklehner; Martin Hrabe de Angelis; Ali Önder Yildirim; Dagmar Zeuschner; Annette Nicke; Leo M. Carlin; Markus Sperandio; Tobias Stoeger; Markus Rehberg
Veröffentlicht in: Advanced Science, 2024, ISSN 2198-3844
Herausgeber: Wiley-VCH GmbH
DOI: 10.1002/ADVS.202404661