Bridging the gaps in nanosafety for animal-free prediction of adverse outcomes

Informacje na temat projektu

nanoPASS

Identyfikator umowy o grant: 101092741

DOI

10.3030/101092741

Data podpisania przez KE 24 Listopada 2022

Data rozpoczęcia 1 Stycznia 2023

Data zakończenia 31 Grudnia 2026

Finansowanie w ramach

• Digital, Industry and Space

Koszt całkowity

€ 3 073 736,25

Wkład UE

€ 3 073 736,25

Koordynowany przez

INSTITUT JOZEF STEFAN
Slovenia

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Data sets, microdata, etc (2)

Time-lapse microscopy data

Quantitative data of KE dynamics, extracted from images of time-lapse microscopy over 1–2 days, for 40+ benchmark and 10+ industrial materials on in vitro models for 4 selected adverse outcomes. The data is organised and documented according to FAIR principles, and formatted as needed for modelling in WP3.

List of NM descriptors and early-events - activity indicators

Compilation of selected NM-relevant data obtained with data mining, relating the molecular initiating events (MIEs) and key events (KEs) towards selected adverse outcomes (AOs) with the markers and in vitro/in silico tests.

Websites, patent fillings, videos etc. (3)

Project Communication Plan (PCP)

A document outlining the overall communication strategy (target audiences, key messages, communication tools, schedule) to ensure consistency and the timely release of information about the project

Project website

The one-stop-shop for project communication, both for external audiences and the consortium with a partner-only area. Will provide a repository (news, deliverables, events), and be the first interface for interested stakeholders with a contact form

Plan for Exploitation & Dissemination of Results (PEDR)

A guidance document, reviewed yearly, supporting dissemination activities through a list of desired exploitation outcomes and related success criteria, and a protocol to assess dissemination suitability and related implementation actions.

Documents, reports (4)

System for detection of inhibition of lung surfactant function

Report describing results from testing of benchmark industrial materials in the lung surfactant bioassay with the developed in vitro acellular system.

Submission of 1 manuscript on an AOP

The manuscript will be based on AOP 237, and it will be submitted to a suitable journal, e.g. ‘Environmental Toxicology and Chemistry’ or ‘Environmental and Molecular Mutagenesis.

Quality Management Plan

The QMP document will detail the roles of partners for the deliverables and milestones, and clear 6-month goals. It will be revised during the course of the project if needed.

ECVAM submission

Report about submission of the proposal for the first animal-free toxicity-prediction method for selected AOs to ECVAM.

Data Management Plan (1)

Management set-up

Set-up of the management structure and decision-making procedures, finalised at the kick-off meeting. Set-up of shared server for exchange of data and files, devised Data Management Plan (DMP) according to FAIR principles.

Other (1)

Predictive QSAR models

Description of physics-based and statistical models to establish quantitative structure-activity and property-activity relationships (QSAR and QSPR, respectively) between the NM descriptors and AO evolution using NM descriptors for selected AOPs.

Publikacje

Peer reviewed articles (15)

Carbonaceous particle exposure triggered accumulation of Osteopontin/SPP1+ macrophages contributes to emphysema development

Autorzy: Han, Lianyong; Haefner, Verena; Yildirim, Ali Önder; Adler, Heiko; Stoeger, Tobias
Opublikowane w: MedComm, 2025, ISSN 2688-2663
Wydawca: Wiley
DOI: 10.1002/MCO2.70061

Acute, controlled inhalation of thin graphene oxide nanosheets in humans with null cardiorespiratory effects.

Autorzy: Ulla Vogel
Opublikowane w: Nature Nanotechnology, Numer 19, 2024, ISSN 1748-3387
Wydawca: Springer Nature
DOI: 10.1038/s41565-024-01639-9

Setting off on the right path: make your research regulatory relevant

Autorzy: Anna Pohl; Elise Morel; Elise Morel; Eric A. J. Bleeker; Sean Kelly; Rachel Smith; Claus Svendsen; Thomas A. J. Kuhlbusch; Thomas A. J. Kuhlbusch; Thomas A. J. Kuhlbusch; Elisabeth Heunisch
Opublikowane w: Frontiers in Research Metrics and Analytics, 2025, ISSN 2504-0537
Wydawca: Frontiers Media
DOI: 10.3389/FRMA.2025.1561964

Particulate matter constituents trigger the formation of extracellular amyloid β and Tau -containing plaques and neurite shortening in vitro

Autorzy: A Sebastijanović, L M Azzurra Camassa, V Malmborg, S Kralj, J Pagels, U Vogel, S Zienolddiny-Narui, I Urbančič, T Koklič and J Štrancar
Opublikowane w: Nanotoxicology, 2024, ISSN 1743-5390
Wydawca: Informa Healthcare
DOI: 10.1080/17435390.2024.2362367

Computational modelling of bionano interface

Autorzy: V. Lobaskin, J. Subbotina, I. Rouse
Opublikowane w: EPL, Numer 143, 2023, ISSN 1286-4854
Wydawca: IOP Science
DOI: 10.1209/0295-5075/acf33f

Nanoparticle-Exposure-Triggered Virus Reactivation Induces Lung Emphysema in Mice

Autorzy: Han L, Haefner V, Yu Y, Han B, Ren H, Irmler M, Beckers J, Liu Q, Feuchtinger A, Yildirim AO, Adler H, Stoeger T
Opublikowane w: ACS Nano, Numer 17/21, 2023, ISSN 1936-086X
Wydawca: American Chemical Society
DOI: 10.1021/acsnano.3c04111

An elevated rate of whole-genome duplications associated with carcinogen exposure in Black cancer patients

Autorzy: Leanne M. Brown; Ryan A. Hagenson; Tilen Koklič; Iztok Urbančič; Janez Strancar; Jason M. Sheltzer
Opublikowane w: Crossref, 2023, ISSN 3067-2007
Wydawca: medRxiv
DOI: 10.1101/2023.11.10.23298349

Detection of Microbial Contamination in Nanomaterials Using LAL, rFC and Cell-Based Assays: Implications for Nanotoxicological Hazard Assessment

Autorzy: Peng Lei; Fikirte Debebe Zegeye; Mayes Alswady-Hoff; Chiara Marcolungo; Pernille Høgh Danielsen; Anne Mette Madsen; Håkan Wallin; Ulla Vogel; Shan Zienolddiny-Narui; Johanna Samulin Erdem
Opublikowane w: Nanomaterials, 2025, ISSN 2079-4991
Wydawca: MDPI
DOI: 10.3390/NANO15241871

NPCoronaPredict: A Computational Pipeline for the Prediction of the Nanoparticle–Biomolecule Corona

Autorzy: Ian Rouse; David Power; Julia Subbotina; Vladimir Lobaskin
Opublikowane w: Journal of Chemical Information and Modeling, 2024, ISSN 1549-960X
Wydawca: American Chemical Society
DOI: 10.48550/ARXIV.2403.07819

<i>UANanoDock</i>: A Web-Based <i>UnitedAtom</i> Multiscale Nanodocking Tool for Predicting Protein Adsorption onto Nanoparticles

Autorzy: Julia Subbotina; Panagiotis D. Kolokathis; Andreas Tsoumanis; Nikolaos K. Sidiropoulos; Ian Rouse; Iseult Lynch; Vladimir Lobaskin; Antreas Afantitis
Opublikowane w: Journal of Chemical Information and Modeling, 2025, ISSN 1549-960X
Wydawca: American Chemical Society
DOI: 10.1021/ACS.JCIM.4C02292

Metadata stewardship in nanosafety research: learning from the past, preparing for an “on-the-fly” FAIR future

Autorzy: Thomas E. Exner; Anastasios G. Papadiamantis; Anastasios G. Papadiamantis; Georgia Melagraki; Jaleesia D. Amos; Nathan Bossa; Nathan Bossa; Georgios P. Gakis; Costas A. Charitidis; Geert Cornelis; Anna L. Costa; Philip Doganis; Lucian Farcal; Steffi Friedrichs; Irini Furxhi; Frederick C. Klaessig; Vladimir Lobaskin; Dieter Maier; John Rumble; John Rumble; Haralambos Sarimveis; Blanca Suarez-Merino; Socorro Vázquez; Mark R. Wiesner; Antreas Afantitis; Antreas Afantitis; Iseult Lynch; Iseult Lynch
Opublikowane w: Frontiers in Physics, 2023, ISSN 2296-424X
Wydawca: Frontiers Media
DOI: 10.5281/ZENODO.8326590

Nature Communications

Autorzy: Leanne M. Brown; Ryan A. Hagenson; Tilen Koklič; Iztok Urbančič; Lu Qiao; Janez Strancar; Jason M. Sheltzer
Opublikowane w: Nature Communications, 2024, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/S41467-024-52554-5

Comparison of Lung Inflammatory and Transcriptional Responses in Mice and Rats Following Pulmonary Exposure to a Fiber Paradigm-Compatible and Non-Compatible MWCNT

Autorzy: Laura Aliisa Saarimäki; Pernille Høgh Danielsen; Kristina Bram Knudsen; Sarah Søs Poulsen; Sabina Halappanavar; Henrik Wolff; Pia Anneli Sofia Kinaret; Dario Greco; Ulla Vogel
Opublikowane w: Nanomaterials, 2025, ISSN 2079-4991
Wydawca: MDPI
DOI: 10.3390/NANO15171364

Beilstein Journal of Nanotechnology

Autorzy: Parinaz Mosaddeghi Amini; Ian Rouse; Julia Subbotina; Vladimir Lobaskin
Opublikowane w: Beilstein Journal of Nanotechnology, 2023, ISSN 2190-4286
Wydawca: Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
DOI: 10.3762/BJNANO.15.21

The eATP/P2×7R Axis Drives Quantum Dot‐Nanoparticle Induced Neutrophil Recruitment in the Pulmonary Microcirculation

Autorzy: Chenxi Li; Qiongliang Liu; Lianyong Han; Haiyun Zhang; Roland Immler; Birgit Rathkolb; Judith Secklehner; Martin Hrabe de Angelis; Ali Önder Yildirim; Dagmar Zeuschner; Annette Nicke; Leo M. Carlin; Markus Sperandio; Tobias Stoeger; Markus Rehberg
Opublikowane w: Advanced Science, 2024, ISSN 2198-3844
Wydawca: Wiley-VCH GmbH
DOI: 10.1002/ADVS.202404661