Platform Optimisation To Enable NanomaTerIAL safety assessment for rapid commercialisation

Informacje na temat projektu

POTENTIAL

Identyfikator umowy o grant: 101092901

DOI

10.3030/101092901

Data podpisania przez KE 24 Listopada 2022

Data rozpoczęcia 1 Stycznia 2023

Data zakończenia 31 Grudnia 2026

Finansowanie w ramach

• Digital, Industry and Space

Koszt całkowity

€ 2 999 787,50

Wkład UE

€ 2 999 787,50

Koordynowany przez

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (5)

Report on the characterisation of intrinsic properties of Ad-NMs and NMPs.

Report summarizing the results from the synthesis and characterisation of the Ad-NMs and NMPs used as cases study.

Release of selected protocols for the determination of sub-acute toxicity of Ad-NMs and NMPs.

Protocols for the evaluation of sub-acute toxicity in vitro in vitro and in vivo models.

Release of selected protocols for the determination of IC50 and LD50 value of the Ad-NMs and NMPs.

Toxicity analyses in in vitro and in vivo models.

Grouping hypotheses and corresponding IATA.

Ad-NM specific grouping hypotheses and corresponding IATA.

Protocols for the determination of long-term effects of Ad-NMs and NMPs.

Imaging-based protocols for characterisation of the uptake, localization, persistence, and degradation of NEPs in biological matrices, in vitro and in vivo.

Websites, patent fillings, videos etc. (1)

Project website and social media profiles.

Website and social media profiles online.

Publikacje

Peer reviewed articles (9)

Normalised similarity assessment to inform grouping of advanced multi-component nanomaterials by means of an Asymmetric Sigmoid function

Autorzy: Alex Zabeo, Georgia Tsiliki, Andrea Brunelli, Elena Badetti, José Balbuena, Danail Hristozov
Opublikowane w: NanoImpact, 2024, ISSN 2452-0748
Wydawca: Elsevier
DOI: 10.1016/j.impact.2024.100519

Understanding the impact of silica nanoparticles in cancer cells through physicochemical and biomolecular characterizations

Autorzy: Asia Saorin; Alberto Martinez-Serra; Germán Jose Paparoni-Bruzual; Michele Crozzolin; Vincenzo Lombardi; Michele Back; Pietro Riello; Marco P. Monopoli; Flavio Rizzolio
Opublikowane w: Materials Advances, 2024, ISSN 2633-5409
Wydawca: The Royal Society of Chemistry
DOI: 10.1039/D4MA00084F

The surface charge both influences the penetration and safety of polystyrene nanoparticles despite the protein corona formation

Autorzy: Giulia Yuri Moscatiello; Carmina Natale; Mariagiovanna Inserra; Annalisa Morelli; Luca Russo; Nora Battajini; Laura Sironi; Davide Panzeri; Alessandro Corbelli; Ada De Luigi; Fabio Fiordaliso; Gabriele Candiani; Paolo Bigini; Luisa Diomede
Opublikowane w: Environmental Science: Nano, 2025, ISSN 2051-8161
Wydawca: Royal Society of Chemistry
DOI: 10.1039/D4EN00962B

Multiple Exposures of Plasma to Nanoparticles: A Novel Tool to Personalize Biomolecular Coronas and Fractionate Fluids

Autorzy: Alberto Martinez-Serra; Jack Cheeseman; Asia Saorin; Mahmoud G. Soliman; Marko Dobricic; Daniel I. R. Spencer; Marco P. Monopoli
Opublikowane w: Analytical Chemistry, 2025, ISSN 1520-6882
Wydawca: American Chemical Society
DOI: 10.1021/ACS.ANALCHEM.4C05573

Protocols for isolation and characterization of nanoparticle biomolecular corona complexes

Autorzy: Mahmoud G. Soliman; Mahmoud G. Soliman; Alberto Martinez-Serra; Marko Dobricic; Duong N. Trinh; Jack Cheeseman; Daniel I. R. Spencer; Marco P. Monopoli
Opublikowane w: Frontiers in Toxicology, 2024, ISSN 2673-3080
Wydawca: Frontiers Media S.A.
DOI: 10.3389/FTOX.2024.1393330

Next Generation Risk Assessment approaches for advanced nanomaterials: Current status and future perspectives

Autorzy: Hristozov D, Badetti E, Bigini P, Brunelli A, Dekkers S, Diomede L, Doak SH, Fransman W, Gajewicz-Skretna A, Giubilato E, Gómez-Cuadrado L, Grafström R, Gutleb AC, Halappanavar S, Hischier R, Hunt N, Katsumiti A, Kermanizadeh A, Marcomini A, Moschini E, O
Opublikowane w: NanoImpact, Numer 24, 2024, ISSN 2452-0748
Wydawca: Elsevier
DOI: 10.1016/j.impact.2024.100523

Roadmap towards safe and sustainable advanced and innovative materials. (Outlook for 2024-2030)

Autorzy: Flemming R. Cassee, Eric A.J. Bleeker, Cyrille Durand, Thomas Exner, Andreas Falk, Steffi Friedrichs, Elisabeth Heunisch, Martin Himly, Sabine Hofer, Norbert Hofstätter, Danail Hristozov, Penny Nymark, Anna Pohl, Lya G. Soeteman-Hernández, Blanca Suarez-Merino, Eugenia Valsami-Jones, Monique Groenewold
Opublikowane w: Computational and Structural Biotechnology Journal, Numer 25, 2026, ISSN 2001-0370
Wydawca: American Association for the Advancement of Science (AAAS)
DOI: 10.1016/J.CSBJ.2024.05.018

Understanding the role of biomolecular coronas in human exposure to nanomaterials

Autorzy: Soliman, Mahmoud G.; Martinez-Serra, Alberto; Antonello, Giulia; Dobricic, Marko; Wilkins, Terence; Serchi, Tommaso; Fenoglio, Ivana; Monopoli, Marco P.
Opublikowane w: Environmental Science: Nano, 2024, ISSN 2051-8161
Wydawca: Royal Society of Chemistry
DOI: 10.1039/D4EN00488D

A Redefined Protocol for Protein Corona Analysis on Graphene Oxide

Autorzy: Asia Saorin, Ahmed Subrati, Alberto Martinez-Serra, Beatriz Alonso, Michael Henry, Paula Meleady, Sergio E. Moya, Marco P. Monopoli
Opublikowane w: ACS Nanoscience Au, Numer 5, 2025, ISSN 2694-2496
Wydawca: American Chemical Society (ACS)
DOI: 10.1021/ACSNANOSCIENCEAU.5C00052

Other (5)

The surface charge dramatically impacts the penetration and the safety of polystyrene nanoparticles in cells and organisms

Autorzy: Giulia Yuri Moscatiello; Carmina Natale; Annalisa Morelli; Luca Russo; Nora Battajini; Laura Sironi; Davide Panzeri; Gabriele Candiani; Luisa Diomede; Paolo Bigini
Opublikowane w: 2023
Wydawca: POTENTIAL
DOI: 10.5281/zenodo.8075344

Correlation between the physico-chemical properties of graphene oxide and its biological effects - NANOTOX 2024

Autorzy: Diomede, Luisa
Opublikowane w: 2025
Wydawca: Zenodo
DOI: 10.5281/ZENODO.15242379

The surface charge of polystyrene nanoparticles impacts their penetration and safety

Autorzy: Bigini, Paolo
Opublikowane w: 2025
Wydawca: Zenodo
DOI: 10.5281/ZENODO.15242329

Platform optimisation to Enable nanomaterial safety assessment for rapid commercialisation (POTENTIAL)

Autorzy: Carmina Natale; Giulia Yuri Moscatiello; Paolo Bigini; Luisa Diomede
Opublikowane w: 2023
Wydawca: POTENTIAL
DOI: 10.5281/zenodo.8075246

Platform Optimisation To Enable NanomaTerIAL safety assessment for rapid commercialisation (POTENTIAL) - NanoKorea 2024

Autorzy: Serchi, Tommaso
Opublikowane w: 2025
Wydawca: Zenodo
DOI: 10.5281/ZENODO.15242276

Conference proceedings (4)

Platform optimisation to Enable nanomaterial safety assessment for rapid commercialisation (POTENTIAL) - Nanomed Europe 2023

Autorzy: Carmina Natale; Giulia Yuri Moscatiello; Paolo Bigini; Luisa Diomede
Opublikowane w: 2023
Wydawca: Zenodo
DOI: 10.5281/ZENODO.8075245

Advancing Protein Corona Analysis of Graphene Oxide

Autorzy: Saorin, Asia; Subrati, Ahmed; Moya, Sergio; Martinez-Serra, Alberto; Alonso, Beatriz; Monopoli, Marco
Opublikowane w: 2025
Wydawca: Zenodo
DOI: 10.5281/ZENODO.15748068

Characterization of graphene oxide dispersions in biological media

Autorzy: Saorin, Asia; Alonso, Beatriz; Subrati, Ahmed; Moya, Sergio; Monopoli, Marco P.
Opublikowane w: 2025
Wydawca: Zenodo
DOI: 10.5281/ZENODO.15242455

Standardised Characterisation of Graphene Oxide to Aid Safety Assessment for Rapid Commercialisation

Autorzy: Ahmed, Subrati; Moya, Sergio; Alonso, Beatriz; Ortega, Amaya
Opublikowane w: 2025
Wydawca: Zenodo
DOI: 10.5281/ZENODO.15242476