Descrizione del progetto
La riparazione delle lesioni del midollo spinale
Le lesioni del midollo spinale (LMS) sono una grave condizione patologica provocata da danni arrecati a tale struttura nervosa, che possono derivare da trauma, malattia o degenerazione. Le LMS si associano a una vasta gamma di menomazioni fisiche, tra cui la paralisi e la perdita di sensibilità. Al momento non esiste alcuna cura per questo tipo di lesioni e i trattamenti esistenti si incentrano sulla gestione dei sintomi e sulla prevenzione di ulteriori lesioni. Finanziato dal Consiglio europeo per l’innovazione, il progetto Piezo4Spine si prefigge di sviluppare una rete biostampata tridimensionale contenente nanovettori che trasportano agenti terapeutici. L’idea è quella di agevolare la riparazione neurale e di promuovere la ripresa funzionale bersagliando molteplici cellule nel midollo spinale. La tecnologia generata sarà alimentata in modalità wireless e offrirà l’opzione di controllare i tempi e i dosaggi associati alle terapie.
Obiettivo
Piezo4Spine aims to develop a novel multifactorial therapy for spinal cord injury (SCI) conceived as a disruptive platform enabling unprecedented multiscale actuation to drive functional neural repair by more accurately tackling SCI complexity. It originally relies on the pivotal role that mechanotransduction plays in the physiology and physiopathology of tissue and organ functions, never explored before for SCI. We will develop a 3D bioprinted mesh containing nanocarriers with therapeutic agents acting at two pivotal aspects of neural repair: mechanotransduction and inhibitory scarring using gene therapy strategies. Bioactive nanocarriers will base on cutting-edge nanoparticles whose release will be electrically triggered on-demand via wireless powering. Such 3D-theramesh offers a novel and exceptionally robust biomaterial for delivering agents at the lesion, controlling time and dose. Current advances on SCI therapies focus on rehabilitation, cell transplantation, drugs, biomaterials, and/or electrical stimulation. Although leading to partial sensory/motor recovery, chronic functional deficits limit daily living activities and shorten live expectancy in SCI patients, as they fail to promote successful axon regeneration at the lesion and awake lost functions. By a multidisciplinary consortium combining scientific, technological, clinical and industrial partners enriched by their interdisciplinarity, we envision to overcome limitations of current technologies by tackling multiple cellular targets involved in neural regeneration after SCI with a balanced combination of therapeutic interventions able to optimally promote functional recovery. These radical science-to-technology breakthroughs could enable, if successful, novel technologies and therapies for SCI and many other neural and non-neural pathologies in which some, but not necessarily all, of these targets are involved. Gender dimension will be implemented by ensuring that findings apply to society as a whole.
Campo scientifico
Parole chiave
Programma(i)
- HORIZON.3.1 - The European Innovation Council (EIC) Main Programme
Invito a presentare proposte
HORIZON-EIC-2022-PATHFINDEROPEN-01
Vedi altri progetti per questo bandoMeccanismo di finanziamento
HORIZON-EIC - HORIZON EIC GrantsCoordinatore
28006 Madrid
Spagna