The LEGATO clinical trial is progressing according to plan. As of 30 November 2025, 132 patients (155 patients as of 16 February 2026, period 3) were recruited out of the total sample size of 411 patients. There are 41 clinical sites authorized to enrol patients from 11 countries as of 30th Nov 2025 (42 clinical sites as of 16 February 2026, period 3). Accrual is slightly slower than expected. Actions were taken and the accrual is going increasingly better. Accrual is expected to be completed by June 2027 instead of March 2027, as previously planned. There is still a possibility of completing the project in time, but it will need to be confirmed at a later stage. According to feedback from clinicians, the study is scientifically sound and there is a huge interest in the neurooncological community. Thus, we are confident about the contribution from the participating sites and we foresee to complete patient recruitment with limited delay. On the health economics side, as it was planned, the activities have been ongoing since project start. After constructing the conceptual value framework, which was submitted as the first deliverable from this work, the model development and the corresponding data collection were started. Finally, regarding communication and dissemination, all milestones and deliverables were completed in time. Project website, social media platforms and newsletters are regularly used, and a new article on health economics was published in open access format. The Plan for dissemination and exploitation deliverable is followed. Active communication is carried out on various platforms according to progress of the clinical trial.
