Key Results:
• Validation of sensor sensitivity: We successfully validated the sensitivity of our whole-cell biosensors, confirming their ability to detect pathogens at early stages.
• Development of a biosensor-integrated device: We progressed in integrating these biosensors into a device, making it the first machine designed to operate with live bacteria. This is a critical advancement that enhances the potential for real-time, automated pathogen detection, which will lead to more efficient and sustainable management practices in aquaculture.
Challenges and Key Needs for Further Success:
• Policy and regulatory challenges: One of the main challenges we face is the lack of specific regulations for machines that operate with whole-cell engineered biosensors. Without clear legislative frameworks, it is difficult to advance the commercialization of such systems. We need policymakers to develop and support regulations that address safety measures and good practices for these types of biotechnological tools.
• Technical challenges in product validation: Another challenge we encountered was the complexity of validating our technology under real infection scenarios. We aim to track naturally occurring infections rather than artificially induced ones, which is more representative of actual farming conditions. This requires gathering sufficient real-world data to ensure the robustness and reliability of our technology.
• IPR and patent support: We have initiated the process of filing a new patent, but we recognize the need for more support in intellectual property rights (IPR) to protect our innovations and secure competitive advantage.
• Funding needs for further R&D: While we have made significant strides, additional funding is crucial to continue our R&D efforts. We require private investment to carry out further product validation, particularly in collaboration with market players, to ensure that the device meets industry demands and can be scaled effectively.
Expected Impact on the European Union:
• Strengthening local fish farming industry: The EU currently imports more than half of the fish consumed by its population, making it one of the largest fish consumers worldwide. Our technology can help local farmers by enabling early disease detection and reducing production losses due to infections. This, in turn, can boost the competitiveness of European aquaculture, promoting sustainable practices and reducing reliance on imports.
• Contribution to EU policy priorities: The outcomes of this project align with the EU’s goals of reducing antibiotic use and promoting sustainable aquaculture practices. By providing farmers with a tool to monitor pathogens early, we can directly contribute to the EU's efforts to enhance food security, reduce environmental impact, and support the growth of a sustainable aquaculture industry.
Policy Recommendations:
• Establishing regulatory frameworks for biosensor technologies: There is an urgent need for EU policymakers to create regulations that address the use of engineered biosensors in agriculture and aquaculture. These frameworks should focus on ensuring the safe use of live bacterial systems, promoting innovation while maintaining safety and environmental standards.
