The nanoSCAN project aims to transform tissue analysis with a novel 3D spatial biology platform that provides crucial insights into cellular and tissue functions.
Current limitations in spatial biology: Spatial biology visualizes the interaction of molecules with their 3D environment, which is essential for cell and tissue screening. However, most spatial biology imaging technologies, based on wide-field microscopy, have limited spatial resolution and insufficient molecular profiling. A major obstacle to quantitative tissue imaging progress is the lack of a single instrument that can cover various complementary scales from tissue to molecule with high speed, high throughput, and high accuracy.
Our innovative SAFe-nSCAN imaging platform: To address these limitations, we propose to develop a new imaging platform, the SAFe-nSCAN, which combines multi-scale optical microscopy solutions, from structured illumination microscopy for rapid cell and tissue inspection and classification to single-molecule localization microscopy techniques for deeper and higher nanoscopic 3D information over preselected regions.
The consortium consists of academic partners who will develop the technology, a non-profit association that will facilitate beta testing and promote the technology, and an SME that will collaborate with a new startup company to manufacture chips and bring molecular resolution spatial biology to the market.
Game-changing technology: NanoSCAN is a game-changing technology that provides crucial 3D spatial biology imaging insights into cellular and tissue function for personalized immune-oncology therapy.
New era of nanoscale resolution: Our platform is a breakthrough imaging technology, covering the entire resolution spectrum and employing new chip technology and a microfluidic device for multiplexed nanoscopy, increasing speed and efficiency. SAFe-nSCAN imaging platform is highly innovative, being the first solution to offer a coverage of the entire length spectrum from tissue to sub-molecule in a single instrument (mm to nm), and imaging at multiple scales, from widefield through structured illumination to single molecule localization microscopy.
