The NanoPUF concept demonstrated that DNA origami-directed nanoparticle placement can create high-density optical fingerprints with intrinsic nanoscale variability, providing a technically feasible route toward physical unclonable labels. In addition, the development of compact dark-field readout prototypes showed that the required optical signatures can be acquired using comparatively simple and low-cost instrumentation. During the project, it became evident that the most promising potential commercial impact may extend beyond anti-counterfeiting and include affordable molecular detection based on plasmonics. The project generated scientifically and technically relevant results that may support future applications of plasmonic nanostructures in authentication and molecular sensing. To ensure further uptake and success, additional research and demonstration are needed, particularly to improve robustness, validate performance under application-relevant conditions, and benchmark sensitivity, specificity, reproducibility, and scalability. Further IPR support will also be important, especially for the emerging plasmonic sensing concept, together with continued technical development toward standardized fabrication and readout protocols. At the end of the project, the main results are a reliable NanoPUF fabrication concept, optically characterized PUF labels, 3D-printed microscope prototypes and a new scientific and technical basis for a plasmonic single-molecule sensing platform.