Novel precision fermentation process to produce animal-free bioidentical ovalbumin

Informacje na temat projektu

Bioalbumen

Identyfikator umowy o grant: 101188965

DOI

10.3030/101188965

Data podpisania przez KE 25 Listopada 2024

Data rozpoczęcia 1 Stycznia 2025

Data zakończenia 31 Grudnia 2026

Finansowanie w ramach

• The European Innovation Council (EIC)

Koszt całkowity

Brak danych

Wkład UE

€ 2 499 999,00

Koordynowany przez

ONEGO BIO LTD
Finland

Periodic Reporting for period 1 - Bioalbumen (Novel precision fermentation process to produce animal-free bioidentical ovalbumin)

Okres sprawozdawczy: 2025-01-01 do 2025-12-31

Podsumowanie kontekstu i ogólnych celów projektu

Eggs are a critically important commodity in the global food system due to functional and nutritional properties; yet the egg market and supply chains are in a constant crisis mode due to many fragility causing factors such as avian flu cage-free requirements and salmonella. Onego Bio makes it possible to manufacture egg protein entirely outside the poultry supply chain. We have developed a highly scalable precision fermentation process using the patented Trichoderma reesei fermentation-based production to produce animal-free ovalbumin. We aim to produce bioidentical egg protein with cost parity and 87% lower CO2 emissions compared to traditional animal-derived eggs. Ovalbumin is the most important egg protein, responsible for the essential ingredient performance. This single protein ovalbumin can solve all current challenges in the egg market and supply chain. Our product, Bioalbumen provides the nutritional and functional upsides of egg protein, without the environmental, ethical and safety-related drawbacks. Our manufacturing method stabilises the food supply chain and increases food security.
The project’s core objective is to develop and commercialize Onego’s egg white protein that meets the highest standards of functionality, taste, and safety for the food industry. The project activities include both commercial and technical development. The commercial activities are targeted to support Onego’s market, regulatory and customer work and position, while the technical activities include product development and research to scale and optimize the production process.

Prace wykonane od początku projektu do końca okresu sprawozdawczego oraz najważniejsze dotychczasowe rezultaty

During the first 12 months, Onego has made significant technical and scientific progress, both related to strain engineering and process development. Onego Bio achieved a key milestone by developing a T. reesei strain capable of producing ≥20 g/L ovalbumin.
Pilot‑scale work advanced with upstream optimisation (media composition, feeding strategies, induction conditions) and downstream development (filtration, washing etc.), supported by expanded high‑throughput screening capacity.
In parallel, the Onego team has performed background strain comparisons, reduced protease and lipase activities through targeted deletions, and began eliminating unwanted secreted proteins to improve purity and downstream efficiency. These steps supported the rise in product purity and prepared the foundation for industrial‑scale optimisation.

Innowacyjność oraz oczekiwany potencjalny wpływ (w tym dotychczasowe znaczenie społeczno-gospodarcze i szersze implikacje społeczne projektu)

Key needs for future: For the US market, we have regulatory approval and thus further commercialization will require financing for scaling up the production. For the EU market, regulatory approval is under preparatory work.
Key needs for the future: Access to biomanufacturing suitable for precision fermentation food products. This requires large bioreactors and suitable downstream processing equipment and facilities. Not many places in Europe have appropriate facilities for this work. Enabling that requires large CapEx investments to purchase and setup. Access and market competition are needed to achieve the availability of low-cost manufacturing. We are working in a food commodity field, which requires relatively low cost production.