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Inferring patterns of ancestral whole genome duplications (paleopolyploidy) in chelicerates

Descrizione del progetto

Tracciare le duplicazioni dell’intero genoma nell’evoluzione degli invertebrati

La duplicazione dell’intero genoma (WGD), il raddoppio dell’intero materiale genetico di un organismo, è una potente forza evolutiva che favorisce l’innovazione e l’adattamento. Tale processo è ben documentato nelle piante e in alcuni vertebrati, ma il suo ruolo negli invertebrati rimane poco chiaro. Con il supporto del programma di azioni Marie Skłodowska-Curie, il progetto CheliPloidy studierà la WGD nei chelicerati, quali ragni e scorpioni. Utilizzando strumenti genomici e filogenetici avanzati, individuerà antichi segnali di duplicazione e testerà scenari evolutivi concorrenti. I risultati chiariranno i tempi e la frequenza della WGD e metteranno in evidenza l’evoluzione genomica e la diversificazione di questo importante lignaggio di artropodi.

Obiettivo

Whole genome duplication (WGD) is a drastic event that results in the creation of new genetic material and has been suggested to play a major role in evolutionary innovations and adaptation. While ancestral WGDs (paleoploidizations) are common in plants, only a handful examples have been proposed in animals, such as in vertebrates or salmons. Among invertebrates, WGD events have been inferred in chelicerates, an arthropod clade including marine and terrestrial groups – the arachnids. Specifically, a shared event in the common ancestor of spider and scorpions, and up to 3 independent rounds in the marine horseshoe crabs. However, many of these inferences are mostly based on evidence from few loci, such as Hox genes, with a recent study questioning the validity of these conclusions. Therefore, genome-wide investigations with a diverse taxon sampling may help to answer how many paleoploidization events have taken place in chelicerates.

The CheliPloidy project will investigate the signals of WGD in chelicerates using newly assembled complete genome encompassing most of their diversity. Importantly, no study has considered that return to diploidy may have happened at different intervals (delayed rediploidization), scenario compatible with the different gene histories seen in the group. We will employ multiple state-of-the-art methods and develop novel ones to look for these signals. For example, we will analyse thousands of gene families trees, assess their synteny, and compare signals of divergence among within-species paralogs (including ohnologs derived from the WGD). As the phylogeny of chelicerates is contentious, we will test the most likely scenarios –alternative backbone trees– to polarize patterns of WGD (how many and which are shared). Altogheter, this project will not only sheds light on the complex genome evolution and the phylogeny of chelicerates, but also demonstrates how a combination of comparative methods can be used to infer signals of ancient WGDs.

Campo scientifico (EuroSciVoc)

Parole chiave

Programma(i)

Argomento(i)

Meccanismo di finanziamento

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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(si apre in una nuova finestra) HORIZON-MSCA-2024-PF-01

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Coordinatore

UNIVERSITAT DE BARCELONA
Contributo netto dell'UE
€ 194 074,56
Indirizzo
GRAN VIA DE LES CORTS CATALANES 585
08007 Barcelona
Spagna
Regione
Este Cataluña Barcelona
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
Nessun dato

Partner (1)