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Zawartość zarchiwizowana w dniu 2024-05-29

Memory and learning in Alzheimer's disease: involvement of amyloid precursor protein and tau in function and dysfunction of the hippocampal formation

Cel

Alzheimer's disease (AD) is the most common cause of dementia in the Western world, accounting for up to 50-60% of all late-onset dementia cases. Neuropathologically, AD is characterised by abnormal accumulations of intracellular neurofibrillary tangles and extra-cellular amyloid plaques in the brain; additional features are deficits in multiple neurotransmitter signalling systems and synaptic loss. The objectives of this proposal are to study transgenic mouse models to define molecular mechanisms leading to amyloid and tau pathology and examine at what level they impact the normal signalling pathways of cognition.

Our basic aims are to
(i) investigate proliferation, neural differentiation, cell renewal, survival and synaptic plasticity in
(ii) highly relevant single or multiple transgenic AD mouse models with amyloidoses and tauopathies,
(iii) assess cognition, learning, memory and behaviour in the same mouse models and (iv) devise therapies to improve any deficiencies.

We expect the research outlined in this proposal to:
(i) increase our understanding of amyloid and tau pathology, enabling us
(ii) to explore diagnostic biomarkers and drug targets for AD and
(iii) to contribute to the fundamental knowledge of neuro-degenerative disease.

Dziedzina nauki (EuroSciVoc)

Słowa kluczowe

Temat(-y)

Zaproszenie do składania wniosków

FP6-2002-MOBILITY-5
Zobacz inne projekty w ramach tego zaproszenia

System finansowania

EIF - Marie Curie actions-Intra-European Fellowships

Koordynator

KATHOLIEKE UNIVERSITEIT LEUVEN
Wkład UE
Brak danych
Koszt całkowity
Brak danych