Cel The development of novel technologies of immuno-therapies holds great promise for potential future treatment of hitherto difficult to cure viral diseases and tumours. It is to be anticipated that such technologies will provide the physician with potent novel therapies and will be the basis for the establishment and growth of new biotech SMEs. This proposal suggests therefore to combine research work on natural killer (NK) cell immune defences and therapies, with training in bio-informatics and issues of patent applications and management of the biotech business.The research part will deal with mechanisms of the innate immune defence used to control viral infections and tumours. It will focus on receptors used by NK and some myeloid cells to interact with surf ace structures exposed by virally infected and/or tumour cells. Firstly, it will investigate the mechanisms developed by viruses and tumours to avoid or subvert immune defences. In this respect viruses have evolved a large number of genes, which function to interfere with the expression of ligands that could be used by NK cells to trace infected cells. Similarly, many of the same or related target molecules can be found down regulated in tumour cells. Secondly, we will use the molecules recognized by receptors on NK and myeloid cells to develop technologies to boost immune reactions.This will be done by:i) by specific reagents directing immune cells to the infected/malignant target cells andii) by genetically engineering NK cells to provide them with increased activities.We intend to train the students of this RTN in all techniques of immuno-technology including wider aspects of molecular medicine by enrolling them in the established MD/PhD programs of the respective Universities. An exchange of students between the different partners will be organized to ensure that every participant will be trained at different places. Training in bio-informatics using the NK and leukocyte receptor complexes of the human genome. Dziedzina nauki social scienceseducational sciencesdidacticsnatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicineimmunologyimmunotherapymedical and health sciencesclinical medicineoncologyleukemia Słowa kluczowe Cytomegalovirus NK-receptors bioinformatics biotech-business biotech-patents Program(-y) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Temat(-y) MOBILITY-1.1 - Marie Curie Research Training Networks (RTN) Zaproszenie do składania wniosków FP6-2004-MOBILITY-1 Zobacz inne projekty w ramach tego zaproszenia System finansowania RTN - Marie Curie actions-Research Training Networks Koordynator MEDICAL UNIVERSITY OF VIENNA Wkład UE Brak danych Adres Spitalgasse 23 VIENNA Austria Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (11) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko AFFIMED THERAPEUTICS AG Niemcy Wkład UE Brak danych Adres Technologiepark, Im Neuenheimer Feld 582 HEIDELBERG Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych ANTHONY NOLAN TRUST / NOTTINGHAM TRENT UNIVERSITY Zjednoczone Królestwo Wkład UE Brak danych Adres Royal Free Hospital, Pond Street, Hampstead LONDON Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych CHANCELLORS MASTERS & SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Zjednoczone Królestwo Wkład UE Brak danych Adres The Old Schools, Trinity Lane CAMBRIDGE Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych COPENHAGEN BUSINESS SCHOOL Dania Wkład UE Brak danych Adres Solberg Plads 3 FREDERIKSBERG Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych EUROPEAN MOLECULAR BIOLOGY LABORATORY Zjednoczone Królestwo Wkład UE Brak danych Adres Meyerhofstrasse 1 HEIDELBERG Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych EUROPEAN PATENT ORGANISATION Niemcy Wkład UE Brak danych Adres Erhardtstr. 27 MUNICH Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych HEINRICH HEINE UNIVERSITY DÜSSELDORF Niemcy Wkład UE Brak danych Adres Moorenstrasse 5 DÜSSELDORF Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych THE HEBREW UNIVERSITY OF JERUSALEM Izrael Wkład UE Brak danych Adres The Authority for Research and Developement, Edmond J. Safra Campus Givat Ram JERUSALEM Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITAT POMPEU FABRA Hiszpania Wkład UE Brak danych Adres Plaça de la Mercè, 10-12 BARCELONA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITY OF RIJEKA MEDICAL SCHOOL Chorwacja Wkład UE Brak danych Adres Brace Branchetta 20 RIJEKA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych VIENNA UNIVERSITY OF ECONOMICS AND BUSINESS ADMINISTRATION Austria Wkład UE Brak danych Adres Augasse 2-6 VIENNA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych