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Protecting the food chain from prions: shaping European priorities through basic and applied research

Obiettivo

Bovine Spongiform Encephalopathy (BSE) started, 20 years ago, a devastating health and food crisis throughout Europe. Classical BSE is now under control as a result of the meat and bone meal ban. However, tonsil analyses suggest that there may be an alarmingly high number of asymptomatic PrPSc positive cases. Transmission through blood transfusion is another important concern, as are recent “atypical cases” of BSE. Only a profound understanding of the molecular biology of prions will enable us to control them. Thus, to understand why BSE-contaminated food causes vCJD, we need to understand how prions get into food, what happens with them in the gut, how they reach the brain, and how they initiate the chain reaction rapidly leading to death. We have formulated 7 key questions: 1) How can we avoid a new BSE outbreak, or other possible future prion infection of livestock? 2) Why did decontamination of meat and bone meal fail; is there an effective way to decontaminate feedstuffs, soil etc? 3) What is the risk of humans being infected with each of the different prion strains known thus far? 4) Which are the best strategies to implement feasible prion eradication programs? 5) How can we develop a pre-clinical prion blood test? 6) How can we identify human cases with potential secondary transmission? And 7) What is the origin of atypical human CJD cases? We will search for decisive data on the structure of PrPSc, the molecular basis of strains and species barriers, the mechanism of prion conversion, the cell biology of PrPSc, the function of PrPC, and the mechanisms of PrP-associated pathology. This information will be translated into a better estimation of current exposure risk to humans from TSE, evaluation of current intervention strategies, and development of improved decontamination techniques and prion tests. With all this, we will be able to respond to the questions formulated and thus advise the EC on TSE policy for the protection of European consumers..

Campo scientifico

Parole chiave

Programma(i)

Argomento(i)

Invito a presentare proposte

FP7-KBBE-2007-2A
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Meccanismo di finanziamento

CP-IP - Large-scale integrating project

Coordinatore

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Contributo UE
€ 564 126,00
Indirizzo
COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N
15782 Santiago De Compostela
Spagna

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Regione
Noroeste Galicia A Coruña
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Martin Cacheiro Martinez (Mr.)
Collegamenti
Costo totale
Nessun dato

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Ultimo aggiornamento: 1 Agosto 2019

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Permalink: https://cordis.europa.eu/project/id/222887/it

European Union, 2024