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INTEGRATION OF THE SYSTEM MODELS OF INSULIN SIGNALLING AND OF MITOCHONDRIAL FUNCTION AND ITS APPLICATION IN THE STUDY OF COMPLEX DISEASES

Cel

A common trait to disorders such as type 2 diabetes or obesity is the development of insulin resistance. There is evidence indicating the existence of a bidirectional cross-talk between insulin signalling and mitochondrial function that may be relevant for the pathogenesis of those disorders. Based on this, MITIN main goal is to identify novel mitochondrial-dependent mechanisms responsible for the development of insulin resistance. This will be done by the use of technologies of Systems Biology and the generation of computer-based tools that will permit the study of complex biological systems that integrate different regulatory networks. For the global visualization and interpretation of the “insulin signalling/mitochondria” complex system we plan to develop a computational framework that will store and integrate all possible data for each of the subsystems, both currently available data and data generated within the project by transcriptomics and lipidomics analysis. This will allow the prediction of functional associations and interactions between both processes, which will be tested under specific hypothesis-driven studies in mammalian cells, mice and Drosophila. By using a Systems Biology approach and investigating how different perturbations modulate cell transcriptomes, and lipidomes, we aim to identify integrated homeostatic responses involving the insulin signalling network and the mitochondria networks. Validation of some of the strongest associations detected by virtue of the integrated systems biology of insulin signalling/mitochondria will generate high value targets of use in therapy against Complex Diseases such as diabetes, obesity, or pathophysiological traits of the Metabolic Syndrome. Besides, computer-based tools generated in the project will be applicable to the analysis of the mechanisms that trigger other Complex Diseases.

Zaproszenie do składania wniosków

FP7-HEALTH-2007-B
Zobacz inne projekty w ramach tego zaproszenia

Koordynator

FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Adres
Carrer Baldiri Reixac 10-12 Parc Scientific De Barcelona
08028 Barcelona
Hiszpania
Rodzaj działalności
Research Organisations
Wkład UE
€ 678 700
Kontakt administracyjny
Adriana Grosu (Ms.)

Uczestnicy (5)

BARCELONA SUPERCOMPUTING CENTER-CENTRO NACIONAL DE SUPERCOMPUTACION
Hiszpania
Wkład UE
€ 403 931
Adres
Calle Jordi Girona 31
08034 Barcelona
Rodzaj działalności
Research Organisations
Kontakt administracyjny
Mercè Calvet (Ms.)
TEKNOLOGIAN TUTKIMUSKESKUS VTT
Finlandia
Wkład UE
€ 625 336
Adres
Tekniikantie 4 A
02044 VTT Espoo
Rodzaj działalności
Research Organisations
Kontakt administracyjny
Katri Kokkila (Ms.)
THE UNIVERSITY OF LIVERPOOL
United Kingdom
Wkład UE
€ 471 633
Adres
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Jane Cloke (Dr.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Wkład UE
€ 465 153
Adres
Trinity Lane The Old Schools
CB2 1TN Cambridge
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Dawn Edwards (Ms.)
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Niemcy
Wkład UE
€ 311 737
Adres
Im Neuenheimer Feld 280
69120 Heidelberg
Rodzaj działalności
Research Organisations
Kontakt administracyjny
Bettina Crispin (Ms.)