Cel Stem cell therapy for the treatment of many degenerative and life-threatening diseases has opened up a promising and exciting outlook for the future of medicine and drug therapy. The recent discovery of cardiac stem cells (CSCs) present in the adult mammalian heart, including the human, has stimulated a new and exciting field for cardiac biology. These resident cells express defined stem cell markers (i.e. c-kit), are clonogenic, self-renewing and multipotent. They also have significant regenerative potential when injected into the infarcted rat myocardium. However, despite rapid progress, many questions remain to be answered before the clinical potential of adult cardiac stem cells can be fully realized and exploited. Indeed, identifying factors that regulate cardiac stem cell fate is of great importance to design better protocols and interventions for the regeneration of functional contractile mass following myocardial injury. Recent research by myself and colleagues has identified CSC activation and new myocyte formation as playing a key role in exercise training-induced cardiac physiological remodelling in the mouse. In this project, using a controlled-intensity exercise training model and novel genetic fate mapping of CSCs, I will answer the much debated question of whether CSCs are the direct source of new myocyte formation in the adult mammalian mouse heart. Following this, through gene expression array I will determine whether myocyte-dependent growth factor release drives the exercise training induced cellular adaptation of the heart. Then I will evaluate in vitro the role of these pivotal growth factors in regulating CSC fate. Obtaining this key information on stem cell biology will be useful for manipulating the regenerative potential of these cells and therefore in designing the most optimal cellular therapy protocol for myocardial regeneration/repair. Dziedzina nauki natural sciencesbiological sciencescell biologymedical and health sciencesmedical biotechnologycells technologiesstem cells Słowa kluczowe Cardiomyocytes Cell biology Exercise Training Growth Fact Growth Factors Heart Disease Multi-potency Myocardial Regeneration Myocardium Physiology Stem Cell Therapy Stem Cells Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) PEOPLE-2007-4-3.IRG - Marie Curie Action: "International Reintegration Grants" Zaproszenie do składania wniosków FP7-PEOPLE-2007-4-3-IRG Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IRG - International Re-integration Grants (IRG) Koordynator LIVERPOOL JOHN MOORES UNIVERSITY Wkład UE € 100 000,00 Adres Mount Pleasant 70, Rodney House, Rodney Street 2 L3 5UX LIVERPOOL Zjednoczone Królestwo Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Andrew Young (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
