Skip to main content
Przejdź do strony domowej Komisji Europejskiej (odnośnik otworzy się w nowym oknie)
polski pl
CORDIS - Wyniki badań wspieranych przez UE
CORDIS
Zawartość zarchiwizowana w dniu 2024-05-28

Flow-aligned polarised Raman of biomacromolecular entities

Cel

Existing spectroscopic methods do not provide satisfactory data on structure, orientation and interactions of biomacromolecules in their native environments. This is especially true of membrane proteins, a major class of drug target. The structure of formulated glycoprotein biopharmaceuticals and their interactions with their targets are also a challenge for UV spectroscopies due to extremely high concentrations and the near invisibility of the sugars to UV radiation. Infra red methods suffer from water absorbance dominating the analyte signals. We will therefore develop a new technique called flow-aligned polarised Raman (FAPR) spectroscopy, which will have many of the advantages of existing techniques, including using aqueous environments, while avoiding their pitfalls by using visible radiation. We expect to gain new structural data on the studied molecules using FAPR. The applicability of this method will be verified on membrane peptides and proteins and glycoproteins.

Dziedzina nauki (EuroSciVoc)

Słowa kluczowe

Program(-y)

Temat(-y)

Zaproszenie do składania wniosków

FP7-PEOPLE-IEF-2008
Zobacz inne projekty w ramach tego zaproszenia

System finansowania

MC-IEF - Intra-European Fellowships (IEF)

Koordynator

UNIVERSITY OF WARWICK
Wkład UE
€ 181 350,76
Adres
KIRBY CORNER ROAD UNIVERSITY HOUSE
CV4 8UW COVENTRY
Zjednoczone Królestwo
Region
West Midlands (England) West Midlands Coventry
Rodzaj działalności
Higher or Secondary Education Establishments
Linki
Koszt całkowity
Brak danych