Skip to main content
Przejdź do strony domowej Komisji Europejskiej (odnośnik otworzy się w nowym oknie)
polski pl
CORDIS - Wyniki badań wspieranych przez UE
CORDIS
Zawartość zarchiwizowana w dniu 2024-06-20

Synthesis of a new class of potent glycosidase inhibitors: analysis of their biological activities; synthesis of a library of gem-difluoro-carbaglycosides: exploration of sugar-protein interactions

Cel

This proposal aims to make a major contribution to the European Research Area and add value to the EU in specific ways. The host research group at l'Ecole Normale Superieure has developed a fruitful industrial partnership with Sanofi-Aventis that has led to the release of a new antithrombotic agent "Arixtra" on the market last year. This project will synthesise families of related molecules and test their biological activities. The fellowship will allow an exceptional young scientist to diversify his re search, work in a multidisciplinary field gaining new skills in biochemistry and carbohydrate chemistry as well as reinforcing his present skills in synthetic organic chemistry and spectroscopy.
These new skills will allow the fellow to reach a position of professional maturity and give him a multidisciplinary platform to begin a career as an EU academic. The project will synthesise several new families of biologically important sugar mimics based on azacycloheptene intermediates and gain access to novel in dolizidine and pyrrolizidine scaffolds through the use of more complex amines. This work will take advantage of the expertise in the Sinay Group and the synthetic skills of the fellow and will be carried out at l¿Ecole Normale Superieure. Biological evaluation of these new sugar mimics will be carried out in collaboration with Prof P. Vogel (Switzerland) and the active conformation of these molecules will be established in collaboration with Prof. J. Jimenez-Barbero (Madrid). A library of biologically important gem-difluoro-carba-sugar analogues will be generated using methodology developed in the Sinay group. These gem-difluoro-carba-sugars will be used to investigate sugar-protein interactions using NMR (19F) spectroscopy in collaboration with Prof. J. J imenez-Barbero (Madrid) and the biological activities of these sugar mimics will be evaluated in collaboration with Prof P. Vogel (Switzerland).

Dziedzina nauki (EuroSciVoc)

Słowa kluczowe

Temat(-y)

Zaproszenie do składania wniosków

FP6-2002-MOBILITY-5
Zobacz inne projekty w ramach tego zaproszenia

System finansowania

EIF - Marie Curie actions-Intra-European Fellowships

Koordynator

ECOLE NORMALE SUPERIEURE
Wkład UE
Brak danych
Adres


Francja
Koszt całkowity
Brak danych