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Supramolecular Cell Manipulation

Final Report Summary - SUMOMAN (Supramolecular Cell Manipulation)

Supramolecular chemistry and fabrication methods provide excellent means to construct dynamic biological platforms employed for supramolecular cell manipulation experiments. Making use of supramolecular chemistry has been a rewarding task in developing functional
biomaterials and biodevices. Knowing the limitations involved in ordering peptides and proteins at different length scales will hasten the development and improvement of medical and clinical devices. Improved coatings consisting of peptides and proteins have been realized and the procedures guarantee more control over structure and function of these structurally sensitive entities. With the development of supramolecular bioactive nano-platforms on surfaces serving as a reversible dynamic interface to cells, study and manipulation of cellular processes has become possible. Innovative methodologies, such as printing procedures of biological arrays, non fouling coatings, microfluidic gradient devices and living bacteria coatings have been developed and proof of concepts have been initiated. Integrated strategies combining supramolecular stimulus-responsive assemblies with fabrication techniques to engineer stable and functional biological architectures on 2D and 3D surfaces have been described. When such structured surfaces display a defined biological interface with subcellular resolution, a length scale inherently relevant to biorecognition, the communication employing biomolecules with cellular receptors can be modulated and studied with unprecedented spatial and temporal specificity.