Final Report Summary - DSBRECA (Relevance of double strand break repair pathway choice in human disease and cancer)
Thanks to this novel tool, we have been able to find and characterize new cellular factors that are relevant for this process. We have done that by combining chemical treatments with molecules currently in cancer clinical trials or genetic disruption of human genes. Thus, we have uncovered new cellular pathways that control the repair of DNA breaks and we have explored their relevance for cancer appearance and treatment.