Final Report Summary - BIO-MAPS (Bio-mimetic Multi-functional Active Porous Structures)
The objective of this research work is to develop mathematical foundations and geometric computational algorithms to bio-mimetically model fully customized and complex three-dimensional (3D) heterogeneous (multi-material) structures for tissue engineering and 3D Biopirinting.
The main objective of BIO-MAPS project is to develop novel methods and algorithms to design active multi-functional porous structures with controlled micro-architecture to satisfy different and sometimes conflicting functional requirements. The designed models are then used to control 3D bioprinting processes to fabricate designed scaffolds directly from developed computer models.
The developed methods in this period makes more advanced multi-functional tissue scaffold possible. With the developed designed strategies, these developed multi-functional porous structures could be used to provide biological and other functionalities in 3D configuration. The developed reproducible and controllable internal architecture design methods could enhance the cell in-growth while forming the desired tissue structures.
The developed algorithms and methodologies advance the knowledge and the literature in computer-aided design (CAD) of heterogeneous porous scaffolds and 3D additive manufacturing and bioadditive processes. The developed algorithms can be used to design heterogeneous porous scaffolds for not only tissue engineering but also other applications of porous and multi-material structures. In addition, developed multi-nozzle bioadditive processes capable of printing biomaterials with controlled micro-architecture. The results from this research enables 3D bioprinting of not only biomaterials but also with live cells. The impact of these research will be high by enabling 3D tissue and organ printing with live cells.
The main objective of BIO-MAPS project is to develop novel methods and algorithms to design active multi-functional porous structures with controlled micro-architecture to satisfy different and sometimes conflicting functional requirements. The designed models are then used to control 3D bioprinting processes to fabricate designed scaffolds directly from developed computer models.
The developed methods in this period makes more advanced multi-functional tissue scaffold possible. With the developed designed strategies, these developed multi-functional porous structures could be used to provide biological and other functionalities in 3D configuration. The developed reproducible and controllable internal architecture design methods could enhance the cell in-growth while forming the desired tissue structures.
The developed algorithms and methodologies advance the knowledge and the literature in computer-aided design (CAD) of heterogeneous porous scaffolds and 3D additive manufacturing and bioadditive processes. The developed algorithms can be used to design heterogeneous porous scaffolds for not only tissue engineering but also other applications of porous and multi-material structures. In addition, developed multi-nozzle bioadditive processes capable of printing biomaterials with controlled micro-architecture. The results from this research enables 3D bioprinting of not only biomaterials but also with live cells. The impact of these research will be high by enabling 3D tissue and organ printing with live cells.