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Impact of Proteasome Subpopulations on Cardiac Remodeling

Cel

Heart disease is the number one cause of death in Europe and the world. Cardiac remodeling involving cardiac hypertrophy is associated with higher morbidity as well as mortality due to heart disease. Cardiac muscle mass is potentially influenced by the ubiquitin proteasome system (UPS). At the heart of the UPS is the proteasome, which specifically degrades targeted proteins into peptides. The candidate has identified that the cardiac proteasomal core, the 20S proteasome, is a heterogenic group of highly similar multiprotein complexes with different functionality. During the development of cardiac hypertrophy, the assembly and thus the composition of 20S proteasome complexes is distinctly regulated. In consequence, proteasomal activities change non-uniformly. The objective of the proposed study is to analyze the impact of this regulatory mechanism on cardiac remodeling.

Zaproszenie do składania wniosków

FP7-PEOPLE-2011-CIG
Zobacz inne projekty w ramach tego zaproszenia

Koordynator

UNIVERSITATSKLINIKUM HEIDELBERG
Wkład UE
€ 100 000,00
Adres
IM NEUENHEIMER FELD 672
69120 Heidelberg
Niemcy

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Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Thomas Eisenhauer (Mr.)
Linki
Koszt całkowity
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